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| 1 | A unique sequence in the N-terminal regulatory region controls the nuclear localization of KLF8 by cooperating with the C-terminal zinc-fingers显示文摘Kr 眉 p 像像素的因素 8 (KLF8 ) 抄写因素在房间周期前进起一个关键作用, oncogenic 转变,对间充质的转变和侵略上皮。然而,它的原子本地化信号(NLS ) 没被识别。有另外的 KLF monopartite NLS (mNLS ) 和 C2H2 锌手指(ZF ) 的 KLF8 份额,哪个被显示了是为一些另外的 KLF 的 NLS。在这份报告,用指导 PCR 的 mutagenesis 和 immunofluorescent 显微镜学,我们显示出 mNLSs,任何单个 ZF 的删除,或变化的那混乱 Zn2+ 有约束力或联系 DNA 主题没影响 KLF8 的原子本地化。删除 > 然而,从 C 终点的 1.5 ZF 引起了 KLF8 的细胞质的累积。令人惊讶地,氨基酸(aa ) 的删除 151-200 区域几乎从原子核消除了 KLF8。有 PKC 禁止者的 S165A, K171E 或 K171R 变化,或处理导致了部分细胞质的累积。Co-immunoprecipitation 证明 KLF8 与 importin- 交往了,这个相互作用要求了 ZF 主题。aa 1-150 或 201-261 区域的删除独自没改变原子本地化。BrdU 加入和 cyclin D1 倡导者酶试金作为野类型的 KLF8 证明在原子本地化的 KLF8 异种有缺陷者不能支持 DNA 合成或 cyclin D1 倡导者激活。一起拿,这些结果建议 KLF8 有二 NLS,一包围 S165 和 K171 并且另外的是二双人脚踏车 ZF,它为 KLF8 原子本地化和它的细胞的功能的规定是批评的。 | Tina S Mehta Heng Lu Xianhui Wang Alison M Urvalek Kim-Hang H Nguyen Farah Monzur Jojo D Hammond Jameson Q Ma Jihe Zhao | 2009 | Cell Research2009，19，9： | 10 |
| 2 | Clinical and epidemiological characteristics of norovirus gastroenteritis among hospitalized children in Lebanon显示文摘AIM To assess the burden of norovirus(No V) and to determine the diversity of circulating strains among hospitalized children in Lebanon. METHODS Stool samples were collected from children presenting with acute gastroenteritis to six major hospitals in Lebanon. A total of 739 eligible stool samples, testing negative for diarrhea caused by rotavirus as a possible viral pathogen, were collected between January 2011 and June 2013. A standardized questionnaire including demographic, epidemiological and clinical observations was used at the time of hospitalization of children presenting with diarrhea. Viral RNA was extracted from stool samples followed by reverse transcription polymerase chain reaction and nucleotide sequencing of a fragment of the viral protein 1 capsid gene. Multiple sequence alignments were carried out and phylogenetic trees were constructed using the MEGA 6 software.RESULTS Overall, 11.2% of stool samples collected from children aged < 5 years tested positive for No V genogroups Ⅰ(GⅠ) and Ⅱ(GⅡ). GⅡ accounted for 10.6% of the gastroenteritis cases with only five samples being positive for GⅠ(0.7%). The majority of hospitalized children showed symptoms of diarrhea, dehydration, vomiting and fever. Upon sequencing of positive samples and based on their clustering in the phylogenetic tree, 4/5 of GⅠ gastroenteritis cases were designated GⅠ.3 and one case as GⅠ.4. GⅡ.4 was predominantly detected in stool of our study participants(68%). We report a JB-15/KOR/2008 GⅡ.4 Apeldoorn 2008-like variant strain circulating in 2011; this strain was replaced between 2012 and 2013 by a variant sharing homology with the Sydney/NSW0514/2012/AUS GⅡ.4 Sydney 2012 and Sydney 2012/FRA GⅡ.4 strains. We also report the co-circulation of non-GⅡ.4 genotypes among hospitalized children. Our data show that No V gastroenteritis can occur throughout the year with the highest number of cases detected during the hot months.CONCLUSION The majority of No V-associated viral gastroenteritis cases among our participants are attributable to GⅡ.4, which is compatible with results reported worldwide. | Nada M Melhem Hassan Zaraket Khalil Kreidieh Zeinab Ali Moza Hammadi Soha Ghanem Farah Hajar Amjad Haidar Adlette Inati Mariam Rajab Hassan Fakhouri Bassam Ghanem Ghassan Baasiri Ghassan Dbaibo | 2016 | World Journal of Gastroenterology2016，22，48： | 3 |
| 3 | Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis显示文摘 | Rayner Katey J Sheedy Frederick J Esau Christine C Hussain Farah N Temel Ryan E Parathath Saj van Gils Janine M Rayner Alistair J Chang Aaron N Suarez Yajaira Fernandez-Hernando Carlos Fisher Edward A Moore Kathryn J | 2011 | Journal of Clinical Investigation2011，，7： | 2 |
| 4 | 抑郁症的非药物治疗:系统性综述与证据图显示文摘背景抑郁症非药物治疗的疗效比较目前仍然不清楚。方法我们对一些系统性综述作了概述,回顾了随机对照试验(RCT),比较抑郁症非药物治疗的有效性和认知行为治疗(CBT)。对多个电子数据库在2016年2月之前发表的所有文献进行了检索,不限制语言。成对的评阅人进行资料纳入、数据提炼并评估偏倚的风险。在适用的时候进行了荟萃分析。结果我们收录了367项RCT,纳入了约2000名患者,进行了11种治疗,导出17项独立的头对头比较。通过标准化的量表评估,发现CBT、自然疗法、行为干预与躯体活动干预可以降低抑郁的严重程度。然而,这些非药物干预的相对疗效仍然缺乏。这些干预对临床缓解和复发的效果不清楚。CBT的发生率比抗抑郁药物更低。局限性由于证据缺乏一致性、证据不清或偏倚风险高,导致证据的质量只是低到中等,限制了我们研究结果的可信度。结论抑郁症的非药物治疗能减少抑郁症状,在轻度到重度抑郁症患者中,应当合并抗抑郁药物治疗,一同进行。对于非药物治疗的选择,应当根据患者的价值观、偏好、临床和社会因素来与患者共同作出决定。 | Wigdan H Farah Mouaz Alsawas Maria Mainou Fares Alahdab Magdoleen H Farah Ahmed T Ahmed Essa A Mohamed Jehad Almasri Michael R Gionfriddo Ana Castaneda-Guarderas Khaled Mohammed Zhen Wang Noor Asi Craig N Sawchuk Mark D Williams Larry J Prokop M Hassan Murad Annie LeBlanc | 2017 | 英国医学杂志中文版2017，20，11： | 2 |
| 5 | Schistosoma mansoni in mice: the pattern of primary cercarial exposure determines whether a secondary infection post-chemotherapy elicits a T helper 1- or a T helper 2-associated immune response显示文摘 | Farah IO Johansson M Lovgren-Bengtson K | | Scand0，，： | 2 |
| 6 | Parent-adolescent relationships and social adjustment:The case of a collectivistic culture显示文摘 | Scharf M Wiseman H Farah F | 2011 | International Journal of Psychology2011，46，3： | 1 |
| 7 | Neuro-Fuzzy Expert System E_S_CO_V for the Obstacle A-voidance Behavior of Intelligent Autonomous Vehicles显示文摘 | CHOHRA A FARAH A BELLOUCIF M | 1999 | Advance Robotics1999，12，6： | 1 |
| 8 | The relation between quantitative fight ventricular ejection fraction and indices of tricuspid annular motion and myocardial performance 显示文摘 | MILLER D FARAH M G LINER A etal | 2004 | J Am Soc Echocardiogr2004，17，5： | 1 |
| 9 | Viscosity of water-in-oil emulsions: Variation with temperature and water volume fraction显示文摘 | FARAH M A OLIVEJRA R C CALDAS J N | 2005 | Journal of Petroleum Science and Engineering2005，48，： | 1 |
| 10 | Acquired protein C deficiency in a child with acute myelogenous leukemia, splenic, renal, and intestinal infarction显示文摘 | Roula A Farah Khalil S Jalkh Hussein Z Farhat Paul E Sayad Adel M Kadri | 2011 | Blood Coagulation & Fibrinolysis2011，，2： | 1 |
| 11 | Chlorogenic acids from green coffee extract are highly bioavailable in humans显示文摘 | Farah A Monteiro M Donangelo C M | 2008 | J Nutr2008，138，： | 1 |
| 12 | Subretinal injection of preservative- free triamcinolone acetonide and supernatant vehicle in rabbits: an electron microscopy study 显示文摘 | Maia M Penha FM Farah ME | 2008 | Graefe''s Arch Clin Exp Ophthalmol2008，246，： | 1 |
| 13 | Enhancement of Decolorization Rate and COD Removal from Dyes Containing Wastewater by the Addition of Hydrogen Peroxide Under Solar Photocatalytic Oxida- tion 显示文摘 | Ghaly Montaser Y Farah Joseph Y Fathy Amany M | 2007 | Desalination2007，217，13： | 1 |
| 14 | Evaluation of the gastric antiulcerogenic effect of large cardamom (fruits of Amomum subulatum Roxb)显示文摘 | JAFRI M A FARAH JAVED K | 2001 | J Ethnopharmacol2001，75，23： | 1 |
| 15 | Dyes in ocular surgery :principles for use in chromovitrectomy显示文摘 | Farah ME Maia M Rodrigues EB | 2009 | Am J Ophthalmol2009，148，： | 1 |
| 16 | Viscosity of water-in-oil emulsions: Variation with temperature and water volume fraction显示文摘 | Farah M A Oliveira R C Caldas J N | 2005 | Journal of Petroleum Science and Engineering2005，48，2： | 1 |
| 17 | Ordinal Regression Based Model for Personalized Information Retrieval显示文摘 | Farah M | 2009 | Adnances in information retrieval theory2009，1，： | 1 |
| 18 | Motor neu ron disease occurring in a mutant dynactin mouse model is characterized by defects in vesicular trafficking 显示文摘 | Laird F M Farah M H Ackerley S | 2008 | J Neurosci2008，28，9： | 1 |
| 19 | Vacuum-assisted therapy for various wound types including diabetic foot ulcer显示文摘 | Farah R Gantus M Kogan L | 2011 | Harefuah2011，150，3： | 1 |
| 20 | Subretinal injection of preservative-free triamcinolone acetonide and supernatant vehicle in rabbits:an electron microscopy study显示文摘 | Maia M Penha FM Farah ME | | 0，，： | 1 |
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