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| 1 | High prevalence of vitamin A deficiency in Crohn's disease patients according to serum retinol levels and the relative dose-response test显示文摘AIM:To assess the vitamin A status of patients with Crohn's disease(CD) by evaluating serum retinol levels and the relative dose response(RDR) test(liver retinol stores).METHODS:Vitamin A nutritional status was measured by serum retinol obtained by high performance liquid chromatography and the RDR test for evaluation of the hepatic stores.Body composition was performed by densitometry by dual-energy X-ray absorptiometry.Vitamin A dietary intake was assessed from a semiquantitative food frequency questionnaire.RESULTS:This study included 38 CD patients and 33 controls.Low serum retinol concentrations were detected in 29% of CD patients vs 15% in controls(P < 0.005).The RDR test was positive in 37% of CD patients vs 12% in controls,which indicated inadequate hepatic vitamin A stores(P < 0.005).Individuals with hypovitaminosis A had lower BMI and body fat compared with those without this deficiency.There was no association between vitamin A deficiency and its dietary intake,ileal location,presence of disease activity and prior bowel resections.CONCLUSION:Patients with CD have higher prevalence of vitamin A deficiency,as assessed by two independent methods. | Márcia Soares-Mota Tianny A Silva Luanda M Gomes Marco AS Pinto Laura MC Mendon?a Maria Lúcia F Farias Tiago Nunes Andrea Ramalho Cyrla Zaltman | 2015 | World Journal of Gastroenterology2015，21，5： | 4 |
| 2 | Regulatory T cell induction during Plasmodium chabaudi infection modifies the clinical course of experimental autoimmune encephalomyelitis显示文摘 | Farias AS Talaisys RL Blanco YC | | 0，，03： | 1 |
| 3 | Ten years of proteomics in multiple sclerosis显示文摘 | Farias AS Pradella F Schmitt A | 2014 | Proteomics2014，14，： | 1 |
| 4 | Nonin- vasive positive pressure ventilation for acute respiratory failure follow- ing upper abdominal surgery显示文摘 | Faria Debora AS da Silva Edina MK Atallah 61varo N | 2015 | The Cochrane database of systemat- ic reviews2015，10，00： | 1 |
| 5 | Wnt 7a induces pres ynaptie colocalization of a 7-nicotinic acetyleholine receptors and ade nomatous polyposis coli in hippocampal neurons 显示文摘 | Farias GG Valles AS Colombres M | 2007 | J Neurosci2007，27，20： | 1 |
| 6 | Nitric oxide and TNFalpha effects in experimental autoimmune encephalomyelitis demyelination显示文摘 | Farias AS de la Hoz C Castro FR | 2007 | Neuroimmunomodulation2007，14，1： | 1 |
| 7 | Cytokines and intrathecal IgG synthesis in multiple sclerosis patients during clinical remission显示文摘 | Brando CO Ruocco HH Farias AS | 2005 | Arq Neuropsiquiatr2005，63，4： | 1 |
| 8 | Vitamin D3 in- duces IDO+ tolerogenic DCs and enhances Treg, reducing the severity of EAE 显示文摘 | Farias AS Spaqhol GS Bordeaux-Rego P | 2013 | CNS Neurosci Ther2013，19，： | 1 |
| 9 | Disappearance of cerebrospinal fluid oligoclonal bands after natalizumab treatment of multiple sclerosis patients显示文摘 | von Glehn F Farias AS de Oliveira AC | 2012 | Mult Seler2012，18，7： | 1 |
| 10 | c-MYC amplification and expression in astrocytic tumors显示文摘 | Faria MH Khayat AS Burbano RR | | 0，，01： | 1 |
| 11 | Evolution of costs of cancer drugs in a Portuguese hospital显示文摘AIM:To analyze the costs of cancer drugs administered in a Portuguese Hospital compared with the Karolinska Institute study.METHODS:To evaluate spending on cancer drugs, we retrospectively analyzed data on the overall costs of cancer drugs, obtained at the Department of Medical Oncology of the Centro Hospitalar de Entre Douro e Vouga, between 2004 and 2010. In this comparative study we selected only drugs belonging to the following groups:chemotherapy, targeted therapy, immunotherapy and endocrine therapy. The selected drugs were further grouped according to their market placement year:≤ 1998, 1999 to 2002, 2003 to 2005, and 2006 to 2010. Drugs used as supportive therapy and bisphosphonates were excluded.RESULTS:The overall costs of cancer drugs increased gradually between 2004 and 2008(from €1911947 to €3666284), with an increase in the number of patients treated during this period. The expenditure decreased in 2009(€3438155) and increased again in 2010(€3673116), but the costs increment was not the same as in previous years. Chemotherapy and targeted therapy were responsible for most of the expenditure. Drugs placed on the national market before 1999 accounted for more than 50% of the expenditure up to 2007. From 2008, these drugs represented less than 50% of the total expenditure. Cancer drugs placed between 1999 and 2002 accounted for 25%-35% of the costs in all the years studied, while drugs placed between 2003 and 2005 accounted for less than 30%. Drugs placed between 2006 and 2010 were responsible for less than 10% of the expenditure.CONCLUSION:In this study, older drugs were responsible for most of the expenditure up to 2007, which is in agreement with the Karolinska study. | Vania Peixoto Ana Luísa Faria Márcia Gon?alves Joana Macedo Sónia Rego Emilio Macías Aldiro Magano Márcia Loureiro António Araújo | 2014 | World Journal of Clinical Oncology2014，5，2： | 0 |
| 12 | Evaluation of total protein,peroxidase,and nutrients measured by pXRF for the determination of tissue rejuvenation/reinvigoration of Eucalyptus microcorys显示文摘Ontogenetic aging of tissues and the gradual decrease of adventitious rooting are known challenges for the clonal propagation of woody species,hampering clonal forestry programs.This study examined possible signatures of tissue rejuvenation/reinvigoration in different propagated materials of Eucalyptus microcorys by analyzing the total protein profile,peroxidase activity,macro-and micronutrient contents,and adventitious rooting of mini cuttings.The analyses were performed on E.microcorys shoots which were successfully obtained by seminal and grafting propagation,micropropagation with epicormic shoots,and indirect organogenesis.Among four mature trees used in the propagation,tissues from the one with the best propagation results were investigated for signs of tissue rejuvenation and/or reinvigoration.Five individuals from each technique were randomly selected and transferred to a semi-hydroponic'channel'system.After four weeks in the seedbed,the total protein,peroxidase activity,nutrient content and rooting of the mini cuttings were evaluated.SDS-PAGE enabled the differentiation of leaf samples obtained by grafting from the other propagation techniques,as revealed by two distinct bands.Materials obtained by micropropagation with epicormic shoots showed the highest peroxidase activity,while those obtained by seminal propagation and from the selected mature tree showed the lowest peroxidase activity.A portable X-ray fluorescence spectroscope(pXRF)identified adequate nutrient content in most of the nutrients tested in materials obtained by seminal and grafting propagation,and by indirect organogenesis.The analysis of adventitious rooting showed that the highest rooting percentage was observed in mini cuttings from seminal propagation(75%)followed by indirect organogenesis(35%).Based on principal component analysis,it was concluded that rooting of mini cuttings from both seminal propagation and indirect organogenesis was associated with phosphorous,sulphur,and potassium contents,which suggests a higher level of tissue rejuvenation/reinvigoration in these propagated plants.Further studies are recommended to search for other methods that present similarities with the responses to adventitious rooting in forest species and thus optimize the rescue and propagation of plants with distinct ontogenetic stages. | Júlio Cézar Tannure Faria Caius Ribeiro-Kumara William Macedo Delarmelina Filipe Aiura Namorato Dione Richer Momolli Anderson Cleiton José Enéas Ricardo Konzen Dulcinéia de Carvalho Gilvano Ebling Brondani | 2023 | Journal of Forestry Research2023，34，5： | 0 |
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