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| 1 | 一种miRNA标记在胶质瘤侵袭性表型的确定与预后评估中的价值(英文)显示文摘Gliomas represent a disparate group of tumours for which there are to date no cure. Thus,there is a recognized need for new diagnostic and therapeutic approaches based on increased understanding of their molecular nature. We performed the comparison of the microRNA( miRNA) profile of 8 WHO grade II gliomas and 24 higher grade tumours( 2 WHO grade III and 22 glioblastomas) by using the Affymetrix Gene Chip miRNA Array v. 1. 0. A relative quantification method( RT-q PCR) with standard curve was used to confirm the 22 miRNA signature resulted by array analysis. The prognostic performances of the confirmed miRNAs were estimated on the Tumor Cancer Genome Atlas( TCGA) datasets. We identified 22 miRNAs distinguishing grade II gliomas from higher grade tumours.RT-q PCR confirmed the differential expression in the two patients' groups for 13 out of the 22 miRNAs. The analysis of the Glioblastoma Multiforme( GBM) and Lower Grade Glioma( LGG) datasets from TCGA demonstrated the association with prognosis for 6 of those miRNAs. Moreover,in the GBM dataset miR-21 and miR-210 were predictors of worse prognosis in both univariable and multivariable Cox regression analyses( HR 1. 19,P = 0. 04,and HR 1. 18,P = 0. 029 respectively). Our results support a direct contribution of miRNAs to glioma cancerogenesis and suggest that miR-21 and miR-210 may play a role in the aggressive clinical behaviour of glioblastomas. | Barbano R Palumbo O Pasculli B Galasso M Volinia S D'Angelo V Icolaro N Coco M Dimitri L Graziano P Copetti M Valori VM Maiello E Carella M Fazio VM Parrella P | 2014 | 中华神经外科疾病研究杂志2014，13，5： | 6 |
| 2 | Loss of flow induces leukocyte - mediated MMP/TIMP imbalance in dynamic in vitro blood - brain barrier model : role of pro - inflammatory cytokines显示文摘 | Krizanac - Bengez L Hossain M Fazio V | 2006 | Am J Physiol Cell Physiol2006，291，4： | 1 |
| 3 | A microsecond-pulse length,frequency-stabilized virtual-cathode oscillator using a resonant cavity显示文摘 | Fazio M V Freeman B L Hoeberlin R L | 1992 | IEEE Trans on Plasma Sci1992，20，3： | 1 |
| 4 | A microsecond-pulse length, frequency-stabilized virtual-cathode oscillator using a resonant cavity显示文摘 | Fazio M V Freeman B L Hoeberlin R | 1992 | IEEE1992，20，3： | 1 |
| 5 | Loss of flow induces leukocyte-mediated MMP/TIMP imbalance in dynamic in vitro blood brain barrier model role of pro-inftamrnatotry eytokines 显示文摘 | Krizanac-Bengez L Hossain M Fazio V | 2006 | Am J Physiol Cell Physio12006，291，4： | 1 |
| 6 | Segmental dyskinesia in Wolff-Parkinson-White syndrome:a possible cause of dilatative cardiomyopathy显示文摘 | Fazio G Mongiovi' M Sutera L | 2008 | Int J Cardiol2008，123，： | 1 |
| 7 | Intraopera- rive laparoscopic renal ultrasonography: use in ad- vanced laparoscopic renal surgery显示文摘 | Fazio L M Downey D Nguan C Y etal | 2006 | Urology2006，68，： | 1 |
| 8 | Segmental dyskinesia inWolff-Parkinson-White syndrome: a possible cause of dilatativecardiomyopathy显示文摘 | Fazio G Mongiovi'M Sutera L | 2008 | Int J Cardiol2008，123，2： | 1 |
| 9 | Determination of flavonoids in citrus juices by micro-HPLC-ESI/MS显示文摘 | Dugo P Presti M L Ohman M Fazio A Dugo G Mondello L | 2005 | J Sep Sci2005，28，： | 1 |
| 10 | Loss of flow induces leukocyte-mediated MMP/TIMP imbalance in dynamic in vitro blood-brain barrier model: role of pro-inflammatory cytokines显示文摘 | Krizanac-Bengez L Hossain M Fazio V | 2006 | Am J Physiol Cell Physiol2006，291，4： | 1 |
| 11 | A microsecond-pulse-length, frequency-stabilized virtual-cathode oscillator using a resonant cavity显示文摘 | Fazio M V Freenman B L Hoeberling R F | 1992 | IEEE Transaction on Plasma Science1992，20，3： | 1 |
| 12 | Nanoindentation of CVD diamond: comparison of an FE model with analytical and experimental data显示文摘 | L De Fazio S Syngellakis R J K Wood F M Fugiuele G Sciume | | 0，，： | 1 |
| 13 | Loss of flow induces leukocyte-mediated MMP/TIMP imbalance in dynamic in vitro blood-brain barrier model:role of pro-inflammatory cytokines显示文摘 | Krizanac-Bengez L Hossain M Fazio V | 2006 | Am J Physiol Cell Physiol2006，291，4： | 1 |
| 14 | Segmental dyskinesia in Wolff -Parkinson White syndrome: a possible cause of dilatative cardiomyopathy显示文摘 | Fazio G Mongiovi M Sutera L | 2008 | Int J Cardiol2008，123，： | 1 |
| 15 | A microsecond-pulse length,frequency-stabilized virtual-cathode oscillator using a resonant cavity显示文摘 | M V Fazio B L Freeman R L Hoeberlin etc | 1992 | IEEE Trans Plasma1992，20，3： | 1 |
| 16 | Attributional style, depression, and grade point averages of college students 显示文摘 | Fazio N M Palm L J | 1995 | Psychological Reports1995，83，1： | 1 |
| 17 | Abnormal functional motor lateralization in healthy siblings of patients with schizo- phrenia显示文摘 | Altamura M Fazio L De Salvia M | 2012 | Psychiatry Res2012，203，： | 1 |
| 18 | Loss of flow induces leukocyte-mediated MMP/TIMP imbalance in dynamic in vitro blood-brain barrier model:role of pro-inflammatory cytokines显示文摘 | KRIZAMAC-BENGEZ L HOSSAIN M FAZIO V | 2006 | Am J Physiol Cell Physiol2006，291，4： | 1 |
| 19 | Loss of flow induces leukocyte-mediated MMP/TIMP imbalance in dynamic in vitro blood-brain barrier model: role of pro-inflammatory cytokines 显示文摘 | Krizanac-Bengez L Hossain M Fazio V | 2006 | Am J Physiol Cell Physiol2006，291，4： | 1 |
| 20 | Attributional style, depression, and grade pointaverages of college students 显示文摘 | FAZIO N M PALM L J | | Psychol Rep0，83，1： | 1 |
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