|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Fecal immunochemical test accuracy in average-risk colorectal cancer screening显示文摘AIM:To assess the fecal immunochemical test(FIT)accuracy for colorectal cancer(CRC)and advanced neoplasia(AN)detection in CRC screening.METHODS:We performed a multicentric,prospective,double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to screening colonoscopy.Two stool samples were collected and the fecal hemoglobin concentration was determined in the first sample(FIT1)and the highest level of both samples(FITmax)using the OC-sensor.Areas under the curve(AUC)for CRC and AN were calculated.The best FIT1and FITmax cut-off values for CRC were determined.At this threshold,number needed to scope(NNS)to detect a CRC and an AN and the cost per lesion detected were calculated.RESULTS:About 779 individuals were included.An AN was found in 97(12.5%)individuals:a CRC in 5(0.6%)and an advanced adenoma(≥10 mm,villous histology or high grade dysplasia)in 92(11.9%)subjects.For CRC diagnosis,FIT1 AUC was 0.96(95%CI:0.95-0.98)and FITmax AUC was 0.95(95%CI:0.93-0.97).For AN,FIT1 and FITmax AUC were similar(0.72,95%CI:0.66-0.78 vs 0.73,95%CI:0.68-0.79,respectively,P=0.34).Depending on the number of determinations and the positivity threshold cut-off used sensitivity for AN detection ranged between 28%and 42%and specificity between 91%and 97%.At the best cut-off point for CRC detection(115 ng/mL),the NNS to detect a CRC were 10.2 and 15.8;and the cost per CRC was 1814€and 2985€on FIT1 and FITmax strategies respectively.At this threshold the sensitivity,NNS and cost per AN detected were 30%,1.76,and 306€,in FIT1 strategy,and 36%,2.26€and 426€,in FITmax strategy,respectively.CONCLUSION:Performing two tests does not improve diagnostic accuracy,but increases cost and NNS to detect a lesion. | Vicent Hernandez Joaquin Cubiella M Carmen Gonzalez-Mao Felipe Iglesias Concepción Rivera M Begoa Iglesias Lucía Cid Ines Castro Luisa de Castro Pablo Vega Jose Antonio Hermo Ramiro Macenlle Alfonso Martínez-Turnes David Martínez-Ares Pamela Estevez Estela Cid M Carmen Vidal Angeles López-Martínez Elisabeth Hijona Marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-Prada the COLONPREV study investigators | 2014 | World Journal of Gastroenterology2014，20，4： | 4 |
| 2 | Outcome in obscure gastrointestinal bleeding after capsule endoscopy显示文摘AIM: To investigate the clinical impact of capsule endoscopy(CE) after an obscure gastrointestinal bleeding(OGIB) episode, focusing on diagnostic work-up, followup and predictive factors of rebleeding. METHODS: Patients who were referred to Hospital del Mar(Barcelona, Spain) between 2007 and 2009 for OGIB who underwent a CE were retrospectively analyzed. Demographic data, current treatment with non-steroid antiinflammtory drugs or anticoagulant drugs, hemoglobin levels, transfusion requirements, previous diagnostic tests for the bleeding episode, as well as CE findings(significant or non-significant), work-up and patient out-comes were analyzed from electronic charts. Variables were compared by χ 2 analysis and Student t test. Risk factors of rebleeding were assessed by Log-rank test, Kaplan-Meier curves and Cox regression model. RESULTS: There were 105 patients [45.7% women, median age of 72 years old(interquartile range 56-79)] and a median follow-up of 326 d(interquartile range 123-641) included in this study. The overall diagnostic yield of CE was 58.1%(55.2% and 63.2%, for patients with occult OGIB and overt OGIB, respectively). In 73 patients(69.5%), OGIB was resolved. Multivariate analysis showed that hemoglobin levels lower than 8 g/dL at diagnosis [hazard ratios(HR) = 2.7, 95%CI: 1.9-6.3], patients aged 70 years and above(HR = 2.1, 95%CI: 1.2-6.1) and significant findings in CE(HR = 2.4, 95%CI: 1.1-5.8) were independent predictors of rebleeding. CONCLUSION: One third of the patients presented with rebleeding after CE; risk factors were hemoglobin levels < 8 g/dL, age ≥ 70 years or the presence of significant lesions. | Alex Caas-Ventura Lucia Márque Xavier Bessa Josep Maria DedeuDepartment of Gastroenterology Hospital del Mar Research Institute Pompeu Fabra University Marc Puigvehí Sílvia Delgado-Aros Ines Ana Ibáez Agustin Seoane Luis Barranco Felipe Bory Montserrat Andreu Begoa González-Suárez | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，11： | 4 |
| 3 | Liver preservation prior to transplantation: Past, present, and future显示文摘Since Dr. Thomas Starzl performed the first series of successful liver transplants(LTs), important advances have been made in immunosuppression, operative techniques, and postoperative care. In 1988, Belzer's group reported the first successful LT using the University of Wisconsin preservation solution(UW).Since then, UW has replaced EuroCollins solution and allowed prolonged and safer preservation of liver, kidney, and pancreas allografts, thus contributing to the improvement of transplant outcomes. Although UW is still considered the standard of care in the United States and in several countries worldwide, a recent meta-analysis revealed similar LT outcomes among UW, Celsior solution, and the Institut Georges Lopez-1 preservation solution, which were slightly superior to those obtained with histidine-tryptophan-ketoglutarate preservation solution.Dynamic preservation has been recently developed, and liver allografts are preserved mainly through the following methods: hypothermic machine perfusion, normothermic machine perfusion, and subnormothermic machine perfusion. Their use has the potential advantage of improving clinical results in LT involving extended criteria donor allografts. Although associated with increased costs, techniques employing machine perfusion of liver allografts have been considered clinically feasible. This editorial focuses on recent advances and future perspectives in liver allograft preservation. | Marcio F Chedid Marcelo A Pinto Jose Felipe G Juchem Tomaz J M Grezzana-Filho Cleber R P Kruel | 2019 | World Journal of Gastrointestinal Surgery2019，11，3： | 4 |
| 4 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 5 | Comparison of the effects of high-pressure treatments and heat pasteurisation on the whey proteins in goat's milk显示文摘 | Felipe X Capellas M Law A R | 1997 | Journal of Agricultural and Food Chemistry1997，45，3： | 1 |
| 6 | Synthesis of wurtzite Zn S nanoparticles using the microwave assisted solvothermal method显示文摘 | FELIPE A L MATEUS M F | 2013 | J Alloy Compd2013，556，： | 1 |
| 7 | Effects of initial pH on biological synthesis of xylitol using xylose-rich hydrolysate 显示文摘 | MORITA T A SILVA S S FELIPE M G A | 2000 | Applied Biochemistry and Biotechnology2000，8486，： | 1 |
| 8 | Generation of inner ear sensory cells from bone marrow-derived human mesenehymal stem cells 显示文摘 | Duran Alonso MB Feijoo-Redondo A Conde de Felipe M | 2012 | Regen Med2012，7，6： | 1 |
| 9 | Molecular characterization and evaluation of mycorrhizal capacity of SuiUus isolates from central spain for the selection of fungal inoculants 显示文摘 | Ruiz D B Rinc6n A M Felipe M R | 2006 | Mycorrhiza2006，16，7： | 1 |
| 10 | Comparison of the effects of highpressure treatment and heat pasteurization on the whey proteins in goats milk显示文摘 | Felipe X Law A J R Capellas M | 1997 | Journal of Agricultural and Food Chemistry1997，45，46： | 1 |
| 11 | Influence of the contrast sensitivity function on the reaction time显示文摘 | A Felipe M J Buades J M Artigas | 1993 | Vision Research1993，33，17： | 1 |
| 12 | Effect of the oxygen transfer coefficient on xylitol production from sugarcane bagasse hydrolysate by continuous stirred-tank reactor fermentation 显示文摘 | MARTINEZ E A SILVA S S FELIPE M G A | 2000 | Applied Biochemistry and Biotechnology2000，8486，： | 1 |
| 13 | FOXP3 expression accurately defines the population of intratumoral regulatory T cells that selectively accumulate in metastatic melanoma lesions显示文摘 | Ahmadzadeh M Felipe Silva A Heemskerk B | 2008 | Blood2008，112，13： | 1 |
| 14 | Recent mortality trends in the Spanish population 显示文摘 | Felipe A Grillen M Perez - Marin A M | 2002 | British Actu- arial Journal2002，8，4： | 1 |
| 15 | Induction of triploidy and gynogenesis in teleost fish with emphasis on marine species显示文摘 | Felip A Zanuy S Carrillo M | 2001 | Genetica2001，111，13： | 1 |
| 16 | Gunshot Wounds of Abdo men:Evaluation of Stable Patients with Triple-contrast Helical CT显示文摘 | Felipe M Curlos M Jorge A | 2004 | Radiology2004，231，： | 1 |
| 17 | Batch xylitol production by Candida guilliermondii FTI20037from sugarcane bagasse hemicellulosic hydrolyzate at controlled pH values显示文摘 | R C L B Rodrigues M G A Felipe I C Roberto | 2003 | Bioprocess Biosyst Eng2003，26，： | 1 |
| 18 | Comparison of the effects of high-pressure treatments and heat pasteurisation on the whey pro- teins in goat' s milk显示文摘 | FELIPE X CAPELLAS M LAW A R | 1997 | Journal of Agricultural and Food Chemistry1997，45，3： | 1 |
| 19 | Proteomic i-dentification,nucleotide sequencc,heterologous expression and immunological reactivity of the triosephosphate isomerase of Paracoc- cidioides brasiliensis 显示文摘 | PEREIRA L A PEREIRA M FELIPE M S S | 2004 | Microbes and Infection2004，6，10： | 1 |
| 20 | Re- sponse surface methodology for xylitol production from sugarcane bagasse hemicellulosic hydrolyzate using controlled vacuum evaporation process variables显示文摘 | Rodrigues R C L B Felipe M G A Silva J B A | 2003 | Process Biochem- istry2003，38，8： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员