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| 1 | Evidence to suggest adoption of water exchange deservesbroader consideration:Its pain alleviating impact occurs in90%of investigators显示文摘AIM: To determine variations in colonoscopy real-time insertion pain among investigators using three different insertion techniques.METHODS: From March 2013 through June 2014, 18-85-year-old diagnostic and 50-70-year-old screening patients were enrolled at each center to on-demand sedation colonoscopy with water exchange(WE), water immersion(WI) and insufflation with air or CO2 for insertion and withdrawal [air or carbon dioxide(AICD)]. Data were aggregated for analysis. Primary outcome: Variations in real-time maximum insertion pain(0 = none, 1-2 = discomfort, 10 = worst).RESULTS: One thousand and ninety-one cases analyzed: WE(n = 371); WI(n = 338); AICD(n = 382). Demographics and indications were comparable. The WE group had the lowest real-time maximum insertion pain score, mean(95%CI): WE 2.8(2.6-3.0), WI 3.8(3.5-4.1) and AICD 4.4(4.1-4.7), P < 0.0005. Ninety percent of the colonoscopists were able to use water exchange to significantly decrease maximum insertion pain scores. One investigator had high insertion pain in all groups, nonetheless WE achieved the lowest real-time maximum insertion pain score. WE had the highest proportions of patients with painless unsedated colonoscopy(vs WI, P = 0.013; vs AICD, P < 0.0005); unsedated colonoscopy with only minor discomfort(vs AICD, P < 0.0005), and completion without sedation(vs AICD, P < 0.0005).CONCLUSION: Aggregate data confirm superiority of WE in lowering colonoscopy real-time maximum insertion pain and need for sedation. Ninety percent of investigators were able to use water exchange to significantly decrease maximum insertion pain scores. Our results suggest that the technique deserves consideration in a broader scale. | Sergio Cadoni Mauro Liggi Premysl Falt Stefano Sanna Mariangela Argiolas Viviana Fanari Paolo Gallittu Donatella Mura Maria L Porcedda Vit Smajstrla Matteo Erriu Felix W Leung | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，2： | 2 |
| 2 | Comparison of accelerated solvent extraction with conventional solvent extraction for organophosphorus pesticides and herbicides显示文摘 | Ezzell J L Richter B E Felix W D | 1995 | LC/GC1995，13，5： | 1 |
| 3 | The Contribution of Internal Audit as A Determinant of External Audit Fees and Factors Influencing this Con- tribution 显示文摘 | Felix W L Gramling A A Maletta M J | 2001 | Journal of Accounting Research2001，39，3： | 1 |
| 4 | Effects of copper supplementation on feedlot performance, carcass characteris- tics,and rumen sulfur metabolism of growing cattle fed diets containing 60% dried distillers grains显示文摘 | Felix T L Weiss W P Fluharty F L | 2012 | Journal of Animal Science2012，90，8： | 1 |
| 5 | Olivine catalysts for methane- and tar-steam reforming显示文摘 | KUHN J N ZHAO Z K Larry G FELIX L G SLIMANE R B CHOI C W OZKAN U S | 2008 | Appl Catal B: Environ2008，81，12： | 1 |
| 6 | The contribution of internal audit as a determinant of external audit fees and factors influencing this contribution 显示文摘 | Felix W L Gramling A A Maletta M J | 2001 | Journal of Accounting Research2001，39，5： | 1 |
| 7 | The contribution of internal auditas a determinant of external audit fees and factors influencing this contribution显示文摘 | Felix W L Jr GramlingA A Maletta M J | 2001 | Journal of Accounting Research2001，，39： | 1 |
| 8 | An intelligent information infrastructure to support knowledge discovery显示文摘 | Henry C W Lau Ralph Lp W L Felix Chan T S | 2002 | Expert System with Application2002，22，1： | 1 |
| 9 | 显示文摘 | Choy K W L Felix E | 2000 | Materials Science and Engineering A2000，278，： | 1 |
| 10 | A RFID case-based logistics resource management system for managing order-picking operations in warehouses显示文摘 | Pooh T C Choy K L Chow Harry K H Lau Henry C W Chan Felix T S Ho K C | 2009 | Expert Systems with Applications2009，，36： | 1 |
| 11 | The contribution of internal audit as a determinant of external audit fees and factors influencing显示文摘 | Felix W L J A Gramling M J Maletta | 2001 | Journal of Accounting Research2001，3，： | 1 |
| 12 | Highbrightness mid-infrared photonic-crystal distributed-feedback lasers显示文摘 | Felix C L Vurgaf Tman I Bewley W W | 2002 | J Mod Optic2002，49，56： | 1 |
| 13 | Etiologic factors of chronic constipationreview of the scientific evidence显示文摘 | Felix W L | 2007 | Digestive Diseases and Science2007，52，2： | 1 |
| 14 | 显示文摘 | Lee DW De Los Santos V L Seo J W Felix L L | 2010 | J Phys Chem B2010，114，17： | 1 |
| 15 | Identification of fraudulent financial statements using linguistic credibility analysis 显示文摘 | Humpherys S L Moffitt K C Burns M B Burgoon J K Felix W F | 2010 | Decision Support Systems2010，，8： | 1 |
| 16 | In-line Process Conditions Monitoring Exert System for Injection Molding 显示文摘 | FELIX T S C HENRY C W L JIANG B | 2000 | Journal of Materials Processing Technology2000，101，1： | 1 |
| 17 | Neonicotinoid pesticide reduces bumble bee colony growth andqueen production显示文摘 | Whitehorn P Stephanie OˇConnor Felix L W | 2012 | Science2012，，35： | 1 |
| 18 | Resuscitation from drowning in cold water显示文摘 | Felix W R MacDonnell K F Jacobs L | 1981 | New Eng J Med1981，304，14： | 1 |
| 19 | An intelligent information infrastructure to support knowledge discovery显示文摘 | HENRY C W L RAOPH W L I FELIX TSC | 2002 | Expert Systems with Applications2002，，22： | 1 |
| 20 | A comparison of accelerated solvent extraction with conventional solvent extraction for organophosphorus pesticides and herbicides 显示文摘 | EZZELL J L RICHTER B E FELIX W D | 1995 | LC/GC1995，13，： | 1 |
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