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| 1 | Evaluation of multidecadal and longer-term temperature changes since 850 CE based on Northern Hemisphere proxy-based reconstructions and model simulations显示文摘The temperature variability over multidecadal and longer timescales(e.g., the cold epochs in the late 15 th, 17 th, and early 19 th centuries) is significant and dominant in the millennium-long, large-scale reconstructions and model simulations;however, their temporal patterns in the reconstructed and simulated temperature series are not well understood and require a detailed assessment and comparison. Here, we compare the reconstructed and simulated temperature series for the Northern Hemisphere(NH) at multidecadal and longer-term timescales(>30 years) by evaluating their covariance, climate sensitivity and amplitude of temperature changes. We found that covariances between different reconstructions or between reconstructions and simulations are generally high for the whole period of 850–1999 CE, due to their similar long-term temporal patterns. However,covariances between different reconstructions or between reconstructions and simulations steadily decline as time series extends further back in time, becoming particularly small during Medieval times. This is related to the large uncetainties in the reconstructions caused by the decreased number of proxy records and sample duplication during the pre-instrumental periods.Reconstructions based solely on tree-ring data show higher skill than multiproxy reconstructions in capturing the amplitude of volcanic cooling simulated by models. Meanwhile, climate models have a shorter recovery(i.e., lag) in response to the cooling caused by volcanic eruptions and solar activity minima, implying the lack of some important feedback mechanisms between external forcing and internal climate processes in climate models. Amplitudes of temperature variations in the latest published tree-ring reconstructions are comparable to those of the multiproxy reconstructions. We found that the temperature difference between the Medieval Climate Anomaly(950–1250 CE) and the Little Ice Age(1450–1850 CE) is generally larger in proxybased reconstructions than in model simulations, but the reason is unclear. | Jianglin WANG Bao YANG Jingyun ZHENG Xuezhen ZHANG Zhiyuan WANG Miao FANG Feng SHI Jingjing LIU | 2020 | Science China Earth Sciences2020，63，8： | 3 |
| 2 | Risk of tuberculosis in patients with rheumatoid arthritis treated with biological and targeted drugs:meta-analysis of randomized clinical trials显示文摘Background:Concerns exist regarding the potential development of tuberculosis in patients with rheumatoid arthritis(RA)treated with biological and targeted drugs.We assessed systematically whether biological therapy increased the risk of tuberculosis in patients with RA by meta-analysis of randomized controlled trials(RCTs).Methods:A systematic literature search was conducted in PubMed,Embase,the Cochrane Library,and China Biology Medicine disc for RCTs evaluating biological therapy in patients with RA from inception through August 2021.Traditional meta-analysis and network meta-analysis were performed to compare the risk of tuberculosis for each biologics class in patients with RA.Peto odds ratio(Peto OR)and its 95%confidence interval(CI)were calculated as the primary effect measure.Results:In total,39 studies with 20,354 patients were included in this meta-analysis,and 82 patients developed tuberculosis.The risk of tuberculosis was increased in patients treated with biologics compared with non-biologics(Peto OR:3.86,95%CI:2.36-6.32,P<0.001).Also,tumor necrosis factor-α(TNF-α)inhibitors had a higher probability of developing tuberculosis than placebo(Peto OR:3.98,95%CI:2.30-6.88,P<0.001).However,network meta-analysis demonstrated that there was no significant difference in the risk of tuberculosis for each biologics class in patients with RA.Noticeably,tuberculosis was significantly more common in patients treated with a high dose compared with patients receiving a low dose of tofacitinib(Peto OR:7.39,95%CI:2.00-27.31,P=0.003).Conclusion:This meta-analysis demonstrates the evidence of an elevated risk of tuberculosis in patients with RA treated with TNF-αinhibitors,and a dose-dependent elevated risk of tuberculosis in patients treated with tofacitinib. | Xiaojian Ji Lidong Hu Yiwen Wang Siliang Man Xingkang Liu Chuan Song Jiaxin Zhang Jian Zhu Jianglin Zhang Feng Huang | 2022 | Chinese Medical Journal2022，，4： | 2 |
| 3 | Tri- block Copolymer Syntheses of Mesoporous Silica with Periodic 50 to 300 Angstrom Pores 显示文摘 | Zhao Dongyuan Feng Jianglin Huo Qisheng | 1998 | Science1998，279，5350： | 1 |
| 4 | Triblock Copolymer Syntheses of Mesoporous Silica with Periodic 50 to 300 Angstrom Pores显示文摘 | Zhao Dongyuan Feng Jianglin Huo Qisheng | 1998 | Science1998，279，5350： | 1 |
| 5 | Nonionie triblock and star diblock eopolymer and oligomerit surfaetant syntheses of highly ordered, hydrotherreally stable, mesoporous silica structures 显示文摘 | Zhao Dongyuan Huo Qisheng Feng Jianglin | 1998 | Journal of American Chemical Society1998，120，24： | 1 |
| 6 | Triblock copolymer syntheses of mesoporous silica with periodic 50 to 300 angstrom pores显示文摘 | Zhao Dongyuan Feng Jianglin Huo Qisheng | 1998 | Science1998，279，： | 1 |
| 7 | Triblock Copolymer Syntheses of Mesoporous Silica with Periodic 50 to 300 Angstrom Pores显示文摘 | Feng Jianglin Qisheng Huo | 1998 | Science1998，279，： | 1 |
| 8 | Triblock Copolymer Syntheses of Mesoporous Silica with Periodic 50 to 300 Angstrom Pores显示文摘 | Zhao Dongyuan Feng Jianglin Huo Qisheng | 1998 | Science1998，279，： | 1 |
| 9 | Triblock copolymer syntheses of mesoporous silica with periodic 50 to 300 angstrom pores显示文摘 | ZHAO Dongyuan FENG Jianglin HUO Qisheng | 1998 | Science1998，279，： | 1 |
| 10 | Triblock copo- lymer syntheses of mesopomus silica with periodic 50 to 30 angstom pores 显示文摘 | Zhao Dongyuan Feng Jianglin Huo Qisheng | 1998 | Science1998，279，5350： | 1 |
| 11 | Triblock copolymer syntheses of mesoporous silica with periodic 50 to 300 angstrom pores显示文摘 | ZHAO Dongyuan FENG Jianglin HUO Qisheng etal | 1998 | Science1998，279，： | 1 |
| 12 | Triblock copolymer syntheses of mesoporous silica with periodic 50 to 300 Angstrom pores显示文摘 | Zhao Dongyuan Feng Jianglin Huo Qisheng | 1998 | Sci1998，279，： | 1 |
| 13 | Copoly- mer synthesis of mesoporous silica with periodic 50 to 300 angstrom pores 显示文摘 | Zhao Dongyuan Feng Jianglin Huo Qisheng | 1998 | Science1998，279，54： | 1 |
| 14 | Non- ionic triblock and star diblock copolymer and oligomeric surfactant syntheses of highly ordered, hydrothermally sta- ble, mesoporous silica structures 显示文摘 | Zhao Dongyuan Huo Qisheng Feng Jianglin | 1998 | J Am Chem Soc1998，120，24： | 1 |
| 15 | Nonionic triblock and star diblock copolymer and oligomeric surfactant syntheses of highly ordered, hydrothermally stable, mesoporous silica structures 显示文摘 | Zhao Dongyuan Huo Qisheng Feng Jianglin | 1998 | Journal of American Chemistry Society1998，120，24： | 1 |
| 16 | Tribloek eopolymer syntheses of mesoporous silica with peri- odic 50 to 300 angstrom pores 显示文摘 | Zhao Dongyuan Feng Jianglin Huo Qisheng | 1998 | Science1998，279，： | 1 |
| 17 | Triblock copolymer syntheses of mesoporous silica with periodic 50 to 300 angstrom pores显示文摘 | Zhao Dongyuan Feng Jianglin Huo Oisheng | 1998 | Science1998，279，54： | 1 |
| 18 | Nonionic tr-iblock and star diblock copolymer and oligomeric surfactant syn-theses of highly ordered,hydrothermally stable,mesoporous sili-ca structures显示文摘 | Zhao Dongyuan Huo Qisheng Feng Jianglin | 1998 | J Am Chem Soc1998，120，24： | 1 |
| 19 | Nonionic triblock and star diblock copolymer and oligomeric surfactant syntheses of highly ordered, hy- drothermally stable, mesoporous silica structures 显示文摘 | Zhao Dongyuan Huo Qishen Feng Jianglin | 1998 | JAmer Chem Soc1998，120，： | 1 |
| 20 | Triblock Copolymer Syntheses of Mesoporous Silica with Periodic 50 to 300 Angstrom Pores 显示文摘 | Zhao Dongyuan Feng Jianglin Huo Qisheng | 1998 | Science1998，279，5350： | 1 |
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