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| 1 | Red blood cell membrane-camouflaged nanoparticles: a novel drug delivery system for antitumor application显示文摘Erythrocytes(red blood cells, RBCs) are the most abundant circulating cells in the blood and have been widely used in drug delivery systems(DDS) because of their features of biocompatibility,biodegradability, and long circulating half-life. Accordingly, a 'camouflage' comprised of erythrocyte membranes renders nanoparticles as a platform that combines the advantages of native erythrocyte membranes with those of nanomaterials. Following injection into the blood of animal models, the coated nanoparticles imitate RBCs and interact with the surroundings to achieve long-term circulation. In this review, the biomimetic platform of erythrocyte membrane-coated nano-cores is described with regard to various aspects, with particular focus placed on the coating mechanism, preparation methods, verification methods, and the latest anti-tumor applications. Finally, further functional modifications of the erythrocyte membranes and attempts to fuse the surface properties of multiple cell membranes are discussed,providing a foundation to stimulate extensive research into multifunctional nano-biomimetic systems. | Qing Xia Yongtai Zhang Zhe Li Xuefeng Hou Nianping Feng | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 26 |
| 2 | Improved dissolution and bioavailability of silymarin delivered by a solid dispersion prepared using supercritical fluids显示文摘The objective of this study was to improve the dissolution and bioavailability of silymarin(SM).Solid dispersions(SDs)were prepared using solution-enhanced dispersion by supercritical fluids(SEDS)and evaluated in vitro and in vivo,compared with pure SM powder.The particle sizes,stability,and contents of residual solvent of the prepared SM-SDs with SEDS and solvent evaporation(SE)were investigated.Four polymer matrix materials were evaluated for the preparation of SM-SD-SEDS,and the hydrophilic polymer,polyvinyl pyrrolidone K17,was selected with a ratio of 1:5 between SM and the polymer.Physicochemical analyses using X-ray diffraction and differential scanning calorimetry indicated that SM was dispersed in SD in an amorphous state.The optimized SM-SD-SEDS showed no loss of SM after storage for 6 months and negligible residual solvent(ethanol)was detected using gas chromatography.In vitro drug release was increased from the SM-SDSEDS,as compared with pure SM powder or SM-SD-SE.In vivo,the area under the rat plasma SM concentration-time curve and the maximum plasma SM concentration were 2.4-fold and 1.9-fold higher,respectively,after oral administration of SM-SD-SEDS as compared with an aqueous SM suspension.These results illustrated the potential of using SEDS to prepare SM-SD,further improving the biopharmaceutical properties of this compound. | Gang Yang Yaping Zhao Nianping Feng Yongtai Zhang Ying Liu Beilei Dang | 2015 | Asian Journal of Pharmaceutical Sciences2015，10，3： | 6 |
| 3 | Percutaneous absorption and brain distribution facilitation of borneol on tetramethylpyrazine in a microemulsion-based transdermal therapeutic system显示文摘In this study, we show that the percutaneous absorption and brain distribution of tetramethylpyrazine(TMP) is enhanced when combined with borneol(BN) in a microemulsionbased transdermal therapeutic system(ME-TTS). The formulation of the TMP and BN microemulsion(TEM-BN-ME) was optimized in skin permeation studies in vitro following a uniform experimental design. Male Sprague-Dawley rats were used for the in vivo pharmacokinetic and tissue distribution studies of TMP-BN-ME-TTS. In the pharmacokinetic study, the TMP-BN-ME-TTS treated rats had significantly higher( P < 0.05) C max and AUC of TMP than the TMP-ME-TTS treated rats, indicating that BN improves the rate and extent of TMP percutaneous absorption. In the tissue distribution study, the AUC of TMP in brain was significantly higher in the TMP-BN-ME-TTS group( P < 0.05), indicating that BN facilitates the distribution of TMP in brain. In summary, BN enhanced the percutaneous absorption and brain distribution of TMP in a microemulsion-based transdermal therapeutic system. | Xiaoge Hu Ning Cheng Jihui Zhao Xianghua Piao Yulu Yan Qibo Zhang Kuan Zhou Yongtai Zhang Nianping Feng | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，3： | 4 |
| 4 | Defect self-assembly of metal-organic framework triggers ferroptosis to overcome resistance显示文摘The emergence of multidrug treatment resistance presents a hurdle for the successful chemotherapy of tumours.Ferroptosis,resulting from the iron-dependent accumulation of lipid peroxides,has the potential to reverse multidrug resistance.However,simultaneous delivery of the iron sources,ferroptosis inducers,drugs,and enhanced circulation carriers within matrices remains a significant challenge.Herein,we designed and fabricated a defect self-assembly of metal-organic framework(MOF)-red blood cell(RBC)membrane-camouflaged multi-drug-delivery nanoplatform for combined ferroptosis-apoptosis treatment of multidrug-resistant cancer.Ferroptosis and chemotherapeutic drugs are embedded in the centre of the iron(III)-based MOF at defect sites by coordination with metal clusters during a one-pot solvothermal synthesis process.The RBC membrane could camouflage the nanoplatform for longer circulation.Our results demonstrate that this defect self-assembly-enabled MOF-membrane-camouflaged nanoplatform could deplete the glutathione,amplify the reactive oxidative species oxidative stress,and enable remarkable anticancer properties.Our work provides an alternative strategy for overcoming multidrug resistance,which could regulate the fluidity and permeability of the cell membrane by ferroptosis to downregulate of P-glycoprotein protein expression by ferroptosis.This defect self-assembly-enabled MOF-membrane-camouflaged multi-drug-delivery nanoplatform has great therapeutic potential. | Haibao Peng Xingcai Zhang Peng Yang Jiaxu Zhao Wei Zhang Nianping Feng Wuli Yang Jing Tang | 2023 | Bioactive Materials2023，，1： | 2 |
| 5 | Novel polymeric Nanoparticles containing Tanshione I1 s for the treatment of Hepatoma显示文摘 | Qi Li Yan Wang ( co-author) Nianping Feng | 2008 | J Drug Target2008，16，10： | 1 |
| 6 | Pharmacokinetic comparisons of Shuang - Huang - Lian with the different combinations of its constitutional herbs显示文摘 | Bin Di Nianping Feng Wenying Liu | 2006 | Journal of Ethnopharmacology2006，107，： | 1 |
| 7 | Novel polymeric nanoparticles containing tanshinone IIA for the treatment of hepatoma 显示文摘 | Li Qi Wang Yan Feng Nianping | 2008 | J Drug Target2008，16，10： | 1 |
| 8 | Microemulsion-based novel transdermal delivery system of tetramethylpyrazine: preparation and evaluation in vitro and in vivo显示文摘 | Nianping Feng | 2011 | International Journal of Nanomedicine2011，，： | 1 |
| 9 | Preparation and evaluation of self-microemulsifying drug delivery system of oridonin显示文摘 | Ping Zhang Ying Liu Nianping Feng | 2008 | International Journal of Pharmaceutics2008，355，12： | 1 |
| 10 | Optimization and in situ intestinal absorption of self-microemulsifying drug delivery system of oridonin显示文摘 | Ying Liu Ping Zhang Nianping Feng | 2009 | International Journal of Pharmaceutics2009，365，13： | 1 |
| 11 | Comparison of the metabolism of Baicalin in rats orally administered with Radix scutellariae extract and Shuang-Huang-Lian extract显示文摘 | Nianping Feng Bin Di Wenyins Liu | 2005 | Chem Pharm Bull2005，53，8： | 1 |
| 12 | RGD-modified poly(D,L-lactic acid) nanoparticles enhance tumor targeting of oridonin显示文摘 | Nianping Feng | 2012 | International Journal of Nanomedicine . 2012 (defa)2012，，： | 1 |
| 13 | Measurement and correlation study of silymarin solubility in supercritical carbon dioxide with and without a cosolvent using semi-empirical models and back-propagation artificial neural networks显示文摘The solubility data of compounds in supercritical fluids and the correlation between the experimental solubility data and predicted solubility data are crucial to the development of supercritical technologies. In the present work, the solubility data of silymarin(SM) in both pure supercritical carbon dioxide(SCCO2) and SCCO2 with added cosolvent was measured at temperatures ranging from 308 to 338 K and pressures from 8 to 22 MPa. The experimental data were fit with three semi-empirical density-based models(Chrastil, Bartle and Mendez-Santiago and Teja models) and a back-propagation artificial neural networks(BPANN) model. Interaction parameters for the models were obtained and the percentage of average absolute relative deviation(AARD%) in each calculation was determined. The correlation results were in good agreement with the experimental data. A comparison among the four models revealed that the experimental solubility data were more fit with the BPANN model with AARDs ranging from 1.14% to 2.15% for silymarin in pure SCCO2 and with added cosolvent. The results provide fundamental data for designing the extraction of SM or the preparation of its particle using SCCO2 techniques. | Gang Yang Zhe Li Qun Shao Nianping Feng | 2017 | Asian Journal of Pharmaceutical Sciences2017，12，5： | 0 |
| 14 | Microneedle-based interstitial fluid extraction for drug analysis:Advances,challenges,and prospects显示文摘Similar to blood,interstitial fluid(ISF)contains exogenous drugs and biomarkers and may therefore substitute blood in drug analysis.However,current ISF extraction techniques require bulky instruments and are both time-consuming and complicated,which has inspired the development of viable alternatives such as those relying on skin or tissue puncturing with microneedles.Currently,microneedles are widely employed for transdermal drug delivery and have been successfully used for ISF extraction by different mechanisms to facilitate subsequent analysis.The integration of microneedles with sensors enables in situ ISF analysis and specific compound monitoring,while the integration of monitoring and delivery functions in wearable devices allows real-time dose modification.Herein,we review the progress in drug analysis based on microneedle-assisted ISF extraction and discuss the related future opportunities and challenges. | Shuwen Ma Jiaqi Li Lixia Pei Nianping Feng Yongtai Zhang | 2023 | Journal of Pharmaceutical Analysis2023，13，2： | 0 |
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