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| 1 | KIF2C:a novel link between Wnt/β-catenin and mTORCI signaling in the pathogenesis of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is the most common primary liver malignancy and is the fourth-leading cause of cancer-related deaths worldwide.HCC is refractory to many standard cancer treatments and the prognosis is often poor,highlighting a pressing need to identify biomarkers of aggressiveness and potential targets for future treatments.Kinesin family member 2C(KIF2C)is reported to be highly expressed in several human tumors.Nevertheless,the molecular mechanisms underlying the role of KIF2C in tumor development and progression have not been investigated.In this study,we found that KIF2C expression was significantly upregulated in HCC,and that KIF2C up-regulation was associated with a poor prognosis.Utilizing both gain and loss of function assays,we showed that KIF2C promoted HCC cell proliferation,migration,invasion,and metastasis both in vitro and in vivo.Mechanistically,we identified TBC1D7 as a binding partner of KIF2C,and this interaction disrupts the formation of the TSC complex,resulting in the enhancement of mammalian target of rapamycin complexl(mTORCI)signal transduction.Additionally,we found that KIF2C is a direct target of the Wnt/β-catenin pathway,and acts as a key factor in mediating the crosstalk between Wnt/β-catenin and mTORCI signaling.Thus,the results of our study establish a link between Wnt/β-catenin and mTORCI signaling,which highlights the potential of KIF2C as a therapeutic target for the treatment of HCC. | Shi Wei Miaomiao Dai Chi Zhang Kai Teng Fengwei Wang Hongbo Li Weipeng Sun Zihao Feng Tiebang Kang Xinyuan Guan Ruihua Xu Muyan Cai Dan Xie | 2021 | Protein & Cell2021，12，10： | 8 |
| 2 | Efficient structural seismic performance evaluation method using improved endurance time analysis显示文摘Evaluation of structural performance under seismic excitations from low intensity to high intensity is essential to verify the seismic resistant capacity of a structure, and usually carried out by the incremental dynamic analysis (IDA) method or pushover method. The recently developed endurance time (ET) method is another method that uses dynamic pushover excitations, i.e., endurance time acceleration function, to obtain results similar to those obtained by IDA or pushover methods with low computational cost and acceptable accuracy. This study proposes an improvement on the ET method by considering more restrictions for both the elastic and inelastic response spectra in the generation procedure, and by specifying a target duration. Four reinforced concrete frame structures with 4, 8, 12, and 16 stories are adopted to verify the accuracy of the improved method. Comparison of the results obtained by the proposed method, the ET method and the IDA method shows that the improved method has a higher accuracy than the ET method. For evaluation of structural responses under specifi c ground motion intensity, which is typically required in seismic design codes, the results obtained by the proposed method are compared with fi ve commonly used ground motion selection methods, and shows the proposed method provides acceptable accuracy for engineering applications. | Li Shuang Liu Kun Liu Xiangyang Zhai Changhai Xie Fengwei | 2019 | Earthquake Engineering and Engineering Vibration2019，18，4： | 3 |
| 3 | A temperature responsive adhesive hydrogel for fabrication of flexible electronic sensors显示文摘Flexible electronics are playing an increasingly important role in human health monitoring and healthcare diagnosis.Strong adhesion on human tissue would be ideal for reducing interface resistance and motion artifacts,but arising problems such as skin irritation,rubefaction,and pain upon device removal have hampered their utility.Here,inspired by the temperature reversibility of hydrogen bonding,a skin-friendly conductive hydrogel with multiple-hydrogen bonds was designed by using biocompatible poly(vinyl alcohol)(PVA),phytic acid(PA),and gelatin(Gel).The obtained PVA/PA/Gel(PPG)hydrogel with temperature-triggered tunable mechanic could reliably adhere to skin and detect electrophysiological signals under a hot compress while be readily removed under a cool compress.Furthermore,the additional advantages of transparency,breathability,and antimicrobial activity of the PPG hydrogel ensure its long-time wearable value on the skin.It is both environmentally friendly and cost saving for the waste PPG hydrogel during production can be recycled based on their reversible physical bonding.The PPG hydrogel sensor is expected to have good application prospects to record electrophysiological signals in human health monitoring. | Wan Liu Ruijie Xie Jingyu Zhu Jiansheng Wu Junfeng Hui Xiaoyan Zheng Fengwei Huo Daidi Fan | 2022 | npj Flexible Electronics2022，6，1： | 2 |
| 4 | Rheotogical properties of starchbased materials and starch/poly(lactic acid) blends显示文摘 | Xie Fengwei et at | 2007 | MacromoLecular Symposia2007，，1： | 1 |
| 5 | Gelatinization of cornstarch with different amylase/amylopectin content 显示文摘 | Hongsheng Liu Long Yu Fengwei Xie | 2006 | Carbohydrate Polymers2006，65，3： | 1 |
| 6 | Gelatinization of cornstarch with different amylose/amylopectin content显示文摘 | Hongsheng Liu Long Yu Fengwei Xie Ling Chen | 2006 | Carbohydrate Polymers2006，，3： | 1 |
| 7 | Thermal processing of starch based polymers 显示文摘 | Liu Hongsheng Xie Fengwei Yu Long | 2009 | Progress in Polymer Sci- ence2009，34，12： | 1 |
| 8 | Rheology to understand and optimize processibility,structures and properties of starch polymeric materials显示文摘 | Fengwei Xie Peter J.Halley Luc Averous | | 0，，02： | 1 |
| 9 | Rheological properties of starches with different amylose/amylopectin ratios显示文摘 | XIE Fengwei YU Long SU Bing | 2009 | Journal of Cereal Science2009，49，3： | 1 |
| 10 | Rheological properties and phases transition of starch under shear stress 显示文摘 | Xue Tao Yu Long Xie Fengwei | 2008 | Food Hydrocolloids2008，22，6： | 1 |
| 11 | Rheological properties of starches with different amylose/amylopectin ratios显示文摘 | XIE Fengwei YU Long SU Bin | 2009 | Journal of Cereal Science2009，49，3： | 1 |
| 12 | Regenerating leather waste for flexible pressure sensing applications显示文摘Pressure sensor can be applied in a wide range of fields,such as voice recognition,human motions detection and artificial electronic skin,the sensing of which is greatly influenced by the flexibility and stretchability of substrate materials.Here,based on the piezoresistive effect,new kinds of flexible pressure sensors have been realized from a pair of flexible and biocompatible collagen films:one is coated by silver nanowires(Ag NWs)and the other by interdigital electrode,respectively.The collagen films are regenerated from leather waste and could bring economic benefits to society.The prepared pressure sensors are applied for voice recognition and human motion detection. | Jie Lei Binghua Zou Runan Zhang Kang Zhang Ruijie Xie Weina Zhang Jiansheng Wu Sheng Li Bing Zheng Fengwei Huo | 2019 | Journal of Leather Science and Engineering2019，1，1： | 1 |
| 13 | Effects of amylose and phosphate monoester on aggregation structures of heat-moisture treated potato starches显示文摘 | Binjia Zhang Yue Zhao Xiaoxi Li Panfeng Zhang Lin Li Fengwei Xie Ling Chen | 2013 | Carbohydrate Polymers2013，，： | 1 |
| 14 | Rheology to understand and optimize processibility, structures and properties of starch polymeric materials显示文摘 | Fengwei Xie Peter J. Halley Luc Avérous | 2011 | Progress in Polymer Science2011，，4： | 1 |
| 15 | Thermal Processing of Starch-based Polymers显示文摘 | Hongsheng Liu Fengwei Xie Long Yua | 2009 | Progress in Polymer Science2009，34，： | 1 |
| 16 | Gelatinization of cornstarch with different amylose/amylopectin content显示文摘 | Hongsheng Liu Long Yu Fengwei Xie Ling Chen | 2006 | Carbohydrate Polymers2006，，3： | 1 |
| 17 | Rheological properties of starches with different amylose/amylopectin ratios 显示文摘 | Xie Fengwei Yu Long Su Bing | 2009 | Journal of Cereal Science2009，49，3： | 1 |
| 18 | Thermal processing of starch-based polymers 显示文摘 | Hongsheng Liu Fengwei Xie Long Yu | 2009 | Progress in Polymer Science2009，34，12： | 1 |
| 19 | Shear degradation of molecular, crystalline, and granular structures of starch during extrusion 显示文摘 | Ming Li Fengwei Xie | 2014 | Starch- starke2014，，： | 1 |
| 20 | Gelatinization of corn starch with different amylose/amylopectin content显示文摘 | LIU Hongsheng YU long XIE Fengwei | 2006 | Carbohydrate Polymers2006，65，3： | 1 |
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