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| 1 | Clinical characteristics and effectiveness of antiviral agents in hospitalized children with infectious mononucleosis in China:A multicenter retrospective study显示文摘Importance:The clinical characteristics of infectious mononucleosis(IM)in Chinese children have not been evaluated in multicenter studies,and the effectiveness of antiviral treatment are controversial.Objective:To investigate the clinical characteristics of Chinese children with IM and current status of antiviral therapy for affected patients.Methods:Hospitalized patients with IM were enrolled between 2018 and 2020 in five children’s hospitals in China.The clinical characteristics were compared among four age groups:<3 years,3-<6 years,6-<10 years,and≥10 years.The clinical characteristics of IM and effectiveness of antiviral therapy were compared among patients receiving acyclovir(ACV),ganciclovir(GCV),and no antiviral therapy(i.e.,non-antiviral group).Results:In total,499 patients were analyzed;most patients were 3-<6 years of age.The most common symptoms and signs included fever(100%),lymphadenopathy(98.6%),pharyngitis(86.4%),eyelid edema(76.8%),and snoring(72.9%).There were significant differences in rash,hepatomegaly,and liver dysfunction among the four age groups.Patients aged<3 years had a lower incidence of liver dysfunction and a higher incidence of rash.Among the 499 patients,50.1%were treated with GCV,26.3%were treated with ACV,and 23.6%received no antiviral therapy.Compared with the non-antiviral group,patients in the ACV and GCV groups had longer durations of fever(P<0.001).There were no significant differences in the incidences of complications among the three treatment groups.Interpretation:The incidence of IM in Chinese children peaked at 3-<6 years of age.Clinical features of IM varied according to age.Patients receiving antiviral therapy exhibited more serious clinical manifestations than did patients without antiviral therapy.The effectiveness of antiviral therapy for IM requires further analysis. | Huili Hu Huiling Deng Jing Bi Yi Xu Shuangjie Li Yue Xie Xinrong Sun Dongmeng Wang Xufang Li Wenxian Ouyang Bing Hu Yufeng Zhang He Tang Chunxiao Fang Hui Zhang Lingyun Guo Chen Wang Tianyi Wang Fengxia Yang Tao Jiang Zhengde Xie Gang Liu | 2021 | Pediatric Investigation2021，5，3： | 12 |
| 2 | An analytical biomarker for treatment of patients with recurrent B-ALL after remission induced by infusion of anti-CD19 chimeric antigen receptor T(CAR-T) cells显示文摘Anti-CD19 chimeric antigen receptor-modified T(CAR-T-19) cells have emerged as a powerful targeted immunotherapy for B-cell lineage acute lymphoblastic leukemia with a remarkable clinical response in recent trials. Nonetheless, few data are available on the subsequent clinical monitoring and treatment of the patients, especially those with disease recurrence after CAR-T-19 cell infusion. Here, we analyzed three patients who survived after our phase I clinical trial and who were studied by means of biomarkers reflecting persistence of CAR-T-19 cells in vivo and predictive factors directing further treatment. One patient achieved 9-week sustained complete remission and subsequently received an allogeneic hematopoietic stem cell transplant. Another patient who showed relapse after 20 weeks without detectable leukemia in the cerebrospinal fluid after CAR-T-19 cell treatment was able to achieve a morphological remission under the influence of stand-alone low-dose chemotherapeutic agents. The third patient gradually developed extensive extramedullary involvement in tissues with scarce immune-cell infiltration during a long period of hematopoietic remission after CAR-T-19 cell therapy. Long-term and discontinuous increases in serum cytokines(mainly interleukin 6 and C-reactive protein) were identified in two patients(Nos. 1 and 6) even though only a low copy number of CAR molecules could be detected in their peripheral blood. This finding was suggestive of persistent functional activity of CAR-T-19 cells. Combined analyses of laboratory biomarkers with their clinical manifestations before and after salvage treatment showed that the persistent immunosurveillance mediated by CAR-T-19 cells would inevitably potentiate the leukemia-killing effectiveness of subsequent chemotherapy in patients who showed relapse after CAR-T-19-induced remission. | Yajing Zhang Wenying Zhang Hanren Dai Yao Wang Fengxia Shi Chunmeng Wang Yelei Guo Yang Liu Meixia Chen Kaichao Feng Yan Zhang Chuanjie Liu Qingming Yang Suxia Li Weidong Han | 2016 | Science China(Life Sciences)2016，59，4： | 6 |
| 3 | Relationship between Lightning Activity and Tropospheric Nitrogen Dioxide and the Estimation of Lightning-produced Nitrogen Oxides over China显示文摘To better understand the relationship between lightning activity and nitrogen oxides(NOX) in the troposphere and to estimate lightning-produced NOX(LNOX) production in China more precisely, spatial and temporal distributions of vertical column densities of tropospheric nitrogen dioxide(NO_2VCDs) and lightning activity were analyzed using satellite measurements. The results showed that the spatial distribution of lightning activity is greater in the east than in the west of China, as with NO_2 VCDs. However, the seasonal and annual variation between lightning and NO_2 density show different trends in the east and west. The central Tibetan Plateau is sparsely populated without modern industry, and NO_2 VCDs across the plateau are barely affected by anthropogenic sources. The plateau is an ideal area to study LNOX. By analyzing 15 years of satellite data from that region, it was found that lightning density is in strong agreement with annual, spatial and seasonal variations of NO_2 VCDs, with a correlation coefficient of 0.79 from the linear fit. Combining Beirle's method and the linear fit equation,LNOXproduction in the Chinese interior was determined to be 0.07(0.02–0.27) Tg N yr^(-1) for 1997–2012, within the range of 0.016–0.384 Tg N yr^(-1) from previous estimates. | Fengxia GUO Xiaoyu JU Min BAO Ganyi LU Zupei LIU Yawen LI Yijun MU | 2017 | Advances in Atmospheric Sciences2017，34，2： | 4 |
| 4 | The spectra and temperature of cloud lightning discharge channel显示文摘Spectra of seven cloud lightning discharges are reported for the first time after captured with a Slit-less Spectrograph on Chinese Tibet Plateau. The structural characters are analyzed and compared with the spectra of cloud-to-ground lightning, and the results indicate that the spectra of cloud lightning show two different kinds of structure characteristics. One has the similar structure as those of cloud-to-ground lightning discharge, and the other is absolutely different. Meanwhile, more lines of OII with high excited energy are recorded in the spectra of cloud lightning discharge in comparison with that of cloud-to-ground lighting happening in the same region. Temperatures at different positions are calculated and temperature characteristics of these two sorts are analyzed, based to the wavelength, relative intensities and other transition parameters. We suggest that the physical process in the cloud discharge channels changes with much more rapid velocity and wider range compared to cloud-to-ground lightning. The differences between the two types of cloud discharge also reflect some discrepancies between the discharge characteristics. | WANG Jie YUAN Ping GUO FengXia QIE XiuShu OUYANG YuHua ZHANG YiJun | 2009 | Science China Earth Sciences2009，52，7： | 4 |
| 5 | Sex-determining region Y box-containing genes: regulators and biomarkers in gynecological cancers显示文摘Sex-determining region Y box-containing genes are transcription factors with roles in multiple biological processes, including cell differentiation, proliferation, and apoptosis.Sex-determining region Y box-containing genes have also been shown to act as regulators and biomarkers in the progression of many different cancers, including gynecological cancers such as ovarian, cervical,and endometrial cancer.In this review, we summarize the contrasting regulatory roles of Sex-determining region Y box-containing genes in different gynecological cancers, as promotors with high expression levels or as suppressors with low expression levels.Expression levels of Sex-determining region Y box-containing genes were also identified as biomarkers of clinical features, including International Federation of Gynecology and Obstetrics stage, histopathologic grade together with disease-free survival, and treatment efficacy in patients with gynecological cancers.An understanding of the mechanisms whereby Sex-determining region Y box-containing genes regulate the progression of gynecological cancers will aid in the development of novel diagnostic and therapeutic strategies, while analysis of Sex-determining region Y box-containing expression levels will help to predict the prognosis of patients with gynecological cancers. | Jiali Hu Ke Li Zhanghuan Li Chao Gao Fei Guo Yingmei Wang Fengxia Xue | 2019 | Cancer Biology & Medicine2019，16，3： | 4 |
| 6 | Numerical simulation of 23 June 2016 Yancheng City EF4 tornadic supercell and analysis of lightning activity显示文摘Based on the Weather Research Forecasting(WRF) model that features charging and discharging parameterization,relationships between tornado, hail and lightning were investigated for a tornado-producing(EF4 intensity) supercell thunderstorm over Yancheng City in Jiangsu Province, China, on 23 June 2016. Based on a sounding at 0800, there was a low lifting condensation level, substantial convective available potential energy(CAPE), and strong vertical wind shear near Yancheng City, which promote supercell development. At 1400, observations revealed that hail production and a dramatic increase of positive cloud-to-ground flash rates occurred simultaneously, maximizing five minutes later. The tornado occurred 30 min after the hail production. The time of minimum positive cloud-to-ground flash rates was 15 min later. The simulation indicated that the tornadic supercell moved eastward and that positive cloud-to-ground flash rates increased dramatically at 1400, the same as observed, but their maximum was 5 min later than observed. The simulated updraft volume peaked at 1425 and the simulated downdraft volume maximized5 min later, when the mesocyclone formed. Simulated reflectivities showed no hook echo and horizontal winds for different height at mid-low levels had a different cyclonic shear at 1430, favorable to mesocyclone formation. Based on the simulated results,the region of positively charged graupel ascended resulting from the region of high liquid water content was lifted by the strong updraft, forming a mid-level strong positive charge region. A lower negative charge region formed by the inductive charging mechanism of collisions between graupel and droplets at the bottom of the cloud, conducive to positive cloud-to-ground flashes. | GUO FengXia LI Yang HUANG ZhaoChu WANG ManFei ZENG FanHui LIAN ChunHao MU YiJun | 2017 | Science China Earth Sciences2017，60，12： | 3 |
| 7 | 显示文摘 | Fang Jianhua Zhai Fengxia Guo Xiaoxia | 2007 | J Mater Chem2007，17，10： | 1 |
| 8 | A facile approach for the preparation of cross-linked sulfonated polyimide membranes for fuel cell application显示文摘 | Fang Jianhua Zhai Fengxia Guo Xiaoxia | 2007 | J Mater Chem2007，17，11： | 1 |
| 9 | Cloning and heterologous expression of glucose oxidase gene from Aspergillus niger Z - 25 in Pichia pastor/s 显示文摘 | Guo Yao Lu Fengxia Zhao Haizhen | 2010 | Applied Biochemistry and Biotechnology2010，162，2： | 1 |
| 10 | Regulation of nitrogen starvation responses by the alarmone(p)ppGpp in rice显示文摘Nitrogen is an essential macronutrient for all living organisms and is critical for crop productivity and quality.In higher plants,inorganic nitrogen is absorbed through roots and then assimilated into amino acids by the highly conserved glutamine synthetase/glutamine:2-oxoglutarate aminotransferase(GS/GOGAT)cycle.How nitrogen metabolism and nitrogen starvation responses of plants are regulated remains largely unknown.Previous studies revealed that mutations in the rice ABNORMAL CYTOKININ RESPONSE1(ABC1)gene encoding Fd-GOGAT cause a typical nitrogen deficiency syndrome.Here,we show that ARE2(for ABC1 REPRESSOR2)is a key regulator of nitrogen starvation responses in rice.The are2 mutations partially rescue the nitrogen-deficient phenotype of abc1 and the are2 mutants show enhanced tolerance to nitrogen deficiency,suggesting that ARE2 genetically interacts with ABC1/Fd-GOGAT.ARE2 encodes a chloroplast-localized Rel A/Spo T homolog protein that catalyzes the hydrolysis of guanosine pentaphosphate or tetraphosphate(p)pp Gpp,an alarmone regulating the stringent response in bacteria under nutritional stress conditions.The are2 mutants accumulate excessive amounts of(p)pp Gpp,which correlate with lower levels of photosynthetic proteins and higher amino acid levels.Collectively,these observations suggest that the alarmone(p)pp Gpp mediates nitrogen stress responses and may constitute a highly conserved mechanism from bacteria to plants. | Hanwen Li Jinqiang Nian Shuang Fang Meng Guo Xiahe Huang Fengxia Zhang Qing Wang Jian Zhang Jiaoteng Bai Guojun Dong Peiyong Xin Xianzhi Xie Fan Chen Guodong Wang Yingchun Wang Qian Qian Jianru Zuo Jinfang Chu Xiaohui Ma | 2022 | Journal of Genetics and Genomics2022，49，5： | 1 |
| 11 | The application of lightning forecasting based on surface electrostatic field observations and radar data显示文摘 | ZENG Qingfeng WANG Zhenhui GUO Fengxia | 2013 | Journal of Electrostatics2013，，1： | 1 |
| 12 | 显示文摘 | Guo Xiaoxia Zhai Fengxia Fang Jianhua | 2007 | J Phys Chem B2007，11，13： | 1 |
| 13 | Explaining the Private College Students' English Academic Ability by Social Cultural Perspective显示文摘 | Guo Fengxia | 2015 | International English Education Research2015，，4： | 0 |
| 14 | Estimation of Lightning-Generated NO_(x) in the Mainland of China Based on Cloud-to-Ground Lightning Location Data显示文摘Lightning-generated nitrogen oxides(LNO_(x))have a major influence on the atmosphere and global climate change.Therefore,it is of great importance to obtain a more accurate estimation of LNO_(x).The aim of this study is to provide a reference for the accurate estimation of the total LNO_(x) in the mainland of China based on cloud-to-ground lightning(CG)location data from 2014 to 2018.The energy of each CG flash was based on the number of return strokes per CG flash,the peak current of each return stroke,and the assumed CG breakdown voltage.The energy of intracloud lightning(IC)was based on the estimated frequencies of IC and the assumed energy of each IC flash.Combining the energy of lightning and the number of nitric oxide(NO)molecules produced by unit energy(ρno),the total LNO_(x) production in the mainland of China was determined.The LNO_(x) in the mainland of China estimated in this study is in the range(0.157-0.321)×10^(9) kg per year[Tg(N)yr-1],which is on the high end of other scholars’works.Negative cloud-to-ground lightning(NCG)flashes produce the most moles of NO_(x),while positive cloud-to-ground lightning(PCG)flashes produce the least total moles of NO_(x).The breakdown voltage of PCG is greater than that of IC or NCG,while the latter has a greater output of LNO_(x). | Qi LI Fengxia GUO Xiaoyu JU Ze LIU Mingjun GAN Kun ZHANG Binbin CAI | 2023 | Advances in Atmospheric Sciences2023，40，1： | 0 |
| 15 | Association of the p73 Gene G4C14-to-A4T14 Polymorphism with Increased Gastric Cancer Risk in a Northwestern Chinese Population显示文摘OBJECTIVE To evaluate the p73 gene G4C14-to-A4T14 double nucleotide polymorphism with both increased gastric cancer(GC) risk and different histological subtypes of GC in a northwestern Chinese population. METHODS Genotyping of the polymorphism of the p73 gene was conducted with PCR-CTPP. RESULTS All 385 GC patients including 305 diffuse-type and 80 intestinal-type cases and 412 healthy controls were investigated.The frequencies of p73 AT/AT,AT/GC,and GC/GC genotypes were 28.1%,47.1%,and 24.8% in the controls,and were 22.0%,45.0%,and 33.0% in GC cases respectively;the GC/GC homozygote frequency was higher in GC cases,mainly in diffuse type compared to the controls with OR=1.71(1.16~2.51) and 1.87 (95%CI,1.24~2.81) respectively.The results showed that carriers of the p73 G4A GC/GC homozygote had a 1.71-time higher risk of GC,especially of the diffuse-type GC compared to the controls. The carriers of the AT/GC heterozygote also had a slightly increased risk of GC cancer,mainly on intestinal-type GC.This is the first report that the p73 G4A double-nucleotide polymorphism is associated with an increased risk of diffuse-type gastric cancer. CONCLUTION The p73 G4A GC/GC genotype is associated with an increased risk of gastric cancer,especially of the GC diffuse-type. | Weihua Zhang Xudong Wang Xiaodong Xie Fengxia Guo Rong Yang Yuhua Liu Shijian Xu Yajun Yang | 2008 | Chinese Journal of Clinical Oncology2008，5，3： | 0 |
| 16 | Application value of Qisexingtai hand diagnostic method in diagnosis of coronary artery disease显示文摘OBJECTIVE:To evaluate the diagnostic efficacy of Qisexingtai hand diagnostic method in the diagnosis of coronary artery disease(CAD).METHODS:This was an investigator-initiated,prospective,multi-center,cross-sectional study.All the participants from three hospitals in China had been diagnosed by both Qisexingtai hand diagnostic method and coronary angiography.We compared the two diagnostic methods to calculate the sensitivity,the specificity,the omission diagnostic rate,the mistaken diagnostic rate and accuracy in order to evaluate the diagnostic efficacy of Qisexingtai hand diagnostic method for CAD.RESULTS:A total of 326 subjects were enrolled,diagnosed by both Qisexingtai hand diagnostic method and coronary angiography.As a result,there were 166 positive cases according to Qisexingtai hand diagnostic method,and 131 positive cases according to coronary angiography.Compared with the results of coronary angiography,the sensitivity of Qisexingtai hand diagnostic method was 80.2%,the specificity was 68.7%,the omission diagnostic rate was 19.8%,the mistaken diagnostic rate was 31.3%,and the accuracy was 73.3%.Area under the receiver operating characteristic curve was estimated as 0.735 for all,and 0.718,0.735,0.783 for the three sub-centers.CONCLUSION:Qisexingtai hand diagnostic method with high accuracy and sensitivity has certain application value in the diagnosis of CAD. | LIU Qian ZHAO Zhupei GUO Hua WANG Shiheng HAO Mingzhao QIN Peijie WANG Liuqing LIU Xuechun ZHANG Fengxia AN Hong LI Yu SHI Xueqin ZHU Tingyu LIU Jianfeng WANG Liying XU Tao ZHANG Limei ZOU Xu | 2022 | Journal of Traditional Chinese Medicine2022，42，5： | 0 |
| 17 | Weak and smooth solutions to incompressible Navier-Stokes-Landau-Lifshitz-Maxwell equations显示文摘Considering the Navier-Stokes-Landau-Lifshitz-Maxwell equations,in dimensions two and three,we use Galerkin method to prove the existence of weak solution.Then combine the a priori estimates and induction technique,we obtain the existence of smooth solution. | Boling GUO Fengxia LIU | 2019 | Frontiers of Mathematics in China2019，14，6： | 0 |
| 18 | On the Factors Analysis of Affecting Listening Comprehension in Learning Foreign Language显示文摘 | Fengxia Guo | 2015 | International English Education Research2015，，2： | 0 |
| 19 | Computer-based Test of Spoken English Translation Accuracy Evaluation System with Wireless Mobile Terminal显示文摘 | GUO Fengxia | 2018 | International English Education Research2018，，1： | 0 |
| 20 | Convective Storm VIL and Lightning Nowcasting Using Satellite and Weather Radar Measurements Based on Multi-Task Learning Models显示文摘Convective storms and lightning are among the most important weather phenomena that are challenging to forecast.In this study,a novel multi-task learning(MTL)encoder-decoder U-net neural network was developed to forecast convective storms and lightning with lead times for up to 90 min,using GOES-16 geostationary satellite infrared brightness temperatures(IRBTs),lightning flashes from Geostationary Lightning Mapper(GLM),and vertically integrated liquid(VIL)from Next Generation Weather Radar(NEXRAD).To cope with the heavily skewed distribution of lightning data,a spatiotemporal exponent-weighted loss function and log-transformed lightning normalization approach were developed.The effects of MTL,single-task learning(STL),and IRBTs as auxiliary input features on convection and lightning nowcasting were investigated.The results showed that normalizing the heavily skew-distributed lightning data along with a log-transformation dramatically outperforms the min-max normalization method for nowcasting an intense lightning event.The MTL model significantly outperformed the STL model for both lightning nowcasting and VIL nowcasting,particularly for intense lightning events.The MTL also helped delay the lightning forecast performance decay with the lead times.Furthermore,incorporating satellite IRBTs as auxiliary input features substantially improved lightning nowcasting,but produced little difference in VIL forecasting.Finally,the MTL model performed better for forecasting both lightning and the VIL of organized convective storms than for isolated cells. | Yang LI Yubao LIU Rongfu SUN Fengxia GUO Xiaofeng XU Haixiang XU | 2023 | Advances in Atmospheric Sciences2023，40，5： | 0 |
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