|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Increased presence of effector lymphocytes during Helicobacter hepaticus-induced colitis显示文摘AIM:To identify and characterize drosophila mothers against decapentaplegic(SMAD)3-dependent changes in immune cell populations following infection with Helicobacter hepaticus(H.hepaticus).METHODS:SMAD3 -/-(n=19)and colitis-resistant SMAD3+/-(n=24)mice(8-10 wk of age)were in-fected with H.hepaticus and changes in immune cell populations[T lymphocytes,natural killer(NK)cells,T regulatory cells]were measured in the spleen and mesenteric lymph nodes(MsLNs)at 0 d,3 d,7 d and 28 d post-infection using flow cytometry.Genotypedependent changes in T lymphocytes and granzyme B+ cells were also assessed after 28 d in proximal colon tissue using immunohistochemistry.RESULTS:As previously observed,SMAD3 -/-,but not SMAD3+/-mice,developed colitis,peaking at 4 wk post-infection.No significant changes in T cell subsets were observed in the spleen or in the MsLNs between genotypes at any time point.However,CD4+and CD8+/ CD62Llo cells,an effector T lymphocyte population,as well as NK cells(NKp46/DX5+)were significantly higher in the MsLNs of SMAD3-/-mice at 7 d and 28 d post-infection.In the colon,a higher number of CD3+cells were present in SMAD3-/-compared to SMAD3+/-mice at baseline,which did not significantly change during infection.However,the number of granzyme B+cells,a marker of cytolytic lymphocytes,significantly increased in SMAD3-/-mice 28 d post-infection compared to both SMAD3+/-mice and to baseline values.This was consistent with more severe colitis development in these animals.CONCLUSION:Data suggest that defects in SMAD3 signaling increase susceptibility to H.hepaticus-induced colitis through aberrant activation and/or dysregulation of effector lymphocytes. | Sarah J McCaskey Elizabeth A Rondini Jonathan F Clinthorne Ingeborg M Langohr Elizabeth M Gardner Jenifer I Fenton | 2012 | World Journal of Gastroenterology2012，18，13： | 2 |
| 2 | Biomeehanical efficacy of unipedieular versus bipedieular vertebroplasty for the management of osteoporotic compression fractures显示文摘 | Tomeh A G Mthis J M Fenton D C | 1999 | Spine1999，24，17： | 1 |
| 3 | Un-drained failure mechanisms of slopes in random soil显示文摘 | Zhu H Griffiths D V Fenton G A Zhang L M | 2015 | Engineering Geology2015，191，： | 1 |
| 4 | Finite element modeling of settlements on spatially random soil显示文摘 | Paice G M Griffiths D V Fenton G A | 1996 | Journal of the Geotechnical Engineering Division American Society of Civil Engineering1996，122，9： | 1 |
| 5 | Tofu production from soybeans of full - fat soyflaks using direct and indirect heating processed显示文摘 | Moizuddin S Harvey G Fenton A M | 1999 | Journal of Food Science1999，64，： | 1 |
| 6 | High velocity metal forming-an old technology addresses new problems 显示文摘 | DAEHN G S ALTYNOVA M BALANETHIRAM V S FENTON G PADMANABHAN M TAMHANE A A WINNARD E | 1995 | JOM1995，47，7： | 1 |
| 7 | Sunitinib inhibits MEK/ERK and SAPK/JNK pathways and increases sodium/Io- dide symporter expression in papillary thyroid cancer显示文摘 | Fenton M S Marion K M Salem A K | 2010 | Thy roid2010，20，9： | 1 |
| 8 | Glomerular apoptotic nucleosomes are central target structures for nephritogenic 显示文摘 | Kalaaji M Fenton K A Mortensen E S | 2007 | Kid- ney lnt2007，71，7： | 1 |
| 9 | Genomic resources for Myzus persicae:EST sequencing,SNP identification,and microarray design显示文摘 | Ramsey JS Wilson ACC De Vos M Sun Q Tamborindeguy C Winfield A Malloch G Smith DM Fenton B Gray SM Jander G | | 0，，： | 1 |
| 10 | Toll-like receptors:A family of patternrecognition receptors in mammals 显示文摘 | Armant M A Fenton M J | 2002 | Genome Biol2002，3，： | 1 |
| 11 | Functional characterization of mutant androgen receptors from androgen-independent prostate cancer显示文摘 | Fenton M A Shuster T D Fertig A M | 1997 | Clin Cancer Res1997，3，8： | 1 |
| 12 | Molecular cloning and characterization of mouse LITAF cDNA: Role in the regulation of tumor necrosis factor-alpha (TNF-alpha) gene expression显示文摘 | BOLCATO-BELLEMIN A L MATTEI M G FENTON M | 2004 | Journal of Endotoxin Research2004，10，1： | 1 |
| 13 | Follicular lymphoma with a novel t(14;18) breakpoint involving the immunoglobulin heavy chain switch mu region indicates an origin from germinal center B cells显示文摘 | Fenton J A Vaandrager J W Aarts W M | 2002 | Blood2002，99，2： | 1 |
| 14 | Biomechanical efficacy of unipedicular versus bipedicular vertebroplasty for the management of osteoporotic compression fractures 显示文摘 | TOHMEH A G MATHIS J M FENTON L E | 1999 | Spine1999，24，17： | 1 |
| 15 | Synthesis and characteriza- tion of zwitterionic silicone sulfobetaine surfactants显示文摘 | SNOW S A FENTON W N OWEN M J | 1990 | Langmuir1990，6，： | 1 |
| 16 | Top ten research priorities relating to life after stroke 显示文摘 | Pollock A St George B Fenton M | 2012 | Lancet Neurol2012，11，3： | 1 |
| 17 | Zwitterionic organofunction- al siloxanes as aqueous surfactants: synthesis and characterization of betaine functional siloxanes and their comparison to sulfobetaine functional siloxanes显示文摘 | SNOW S A FENTON W N OWEN M J | 1991 | Langmuir1991，7，： | 1 |
| 18 | Erosional impact on organic matter content and productivity of selected Iowa soils 显示文摘 | FENTON T E Kazemi M LAUTERBACH-BAARRETT M A | 2005 | Soil & Tillage Research2005，81，： | 1 |
| 19 | Fetal distress 显示文摘 | Fenton A N Steer C M | 1962 | Am J Obstet Gynecol1962，83，： | 1 |
| 20 | TLRs differential adapter utilization by Toll like re eeptors mediates TLR-specific patterns of gene ex pression显示文摘 | VOGEL S N FITZGERALD K A FENTON M | 2003 | Mol Interv2003，3，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员