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| 1 | Increased presence of effector lymphocytes during Helicobacter hepaticus-induced colitis显示文摘AIM:To identify and characterize drosophila mothers against decapentaplegic(SMAD)3-dependent changes in immune cell populations following infection with Helicobacter hepaticus(H.hepaticus).METHODS:SMAD3 -/-(n=19)and colitis-resistant SMAD3+/-(n=24)mice(8-10 wk of age)were in-fected with H.hepaticus and changes in immune cell populations[T lymphocytes,natural killer(NK)cells,T regulatory cells]were measured in the spleen and mesenteric lymph nodes(MsLNs)at 0 d,3 d,7 d and 28 d post-infection using flow cytometry.Genotypedependent changes in T lymphocytes and granzyme B+ cells were also assessed after 28 d in proximal colon tissue using immunohistochemistry.RESULTS:As previously observed,SMAD3 -/-,but not SMAD3+/-mice,developed colitis,peaking at 4 wk post-infection.No significant changes in T cell subsets were observed in the spleen or in the MsLNs between genotypes at any time point.However,CD4+and CD8+/ CD62Llo cells,an effector T lymphocyte population,as well as NK cells(NKp46/DX5+)were significantly higher in the MsLNs of SMAD3-/-mice at 7 d and 28 d post-infection.In the colon,a higher number of CD3+cells were present in SMAD3-/-compared to SMAD3+/-mice at baseline,which did not significantly change during infection.However,the number of granzyme B+cells,a marker of cytolytic lymphocytes,significantly increased in SMAD3-/-mice 28 d post-infection compared to both SMAD3+/-mice and to baseline values.This was consistent with more severe colitis development in these animals.CONCLUSION:Data suggest that defects in SMAD3 signaling increase susceptibility to H.hepaticus-induced colitis through aberrant activation and/or dysregulation of effector lymphocytes. | Sarah J McCaskey Elizabeth A Rondini Jonathan F Clinthorne Ingeborg M Langohr Elizabeth M Gardner Jenifer I Fenton | 2012 | World Journal of Gastroenterology2012，18，13： | 2 |
| 2 | The sum of log-normal probability distribution in scatter transmission system显示文摘 | Fenton L F | 1960 | IEEE Transactions on Commu- nications Systems1960，8，1： | 1 |
| 3 | Protection and Systemic Translocation of siRNA Following Oral Administration of Chitosan/siRNA Nanopartides显示文摘 | BaUarin-Gonz:/lez B Dagnaes-Hansen F Fenton RA | 2013 | Mol Ther Nucleic Acids2013，2，： | 1 |
| 4 | Incidence of subsequent vertebral fracture after kyphoplasty显示文摘 | David F Sehweiekert PA Fenton DC et ag | 2004 | Spine2004，29，20： | 1 |
| 5 | Diagnosis and management of supraglottitis (epiglottitis) 显示文摘 | Glynn F Fenton JE | 2008 | Curt Infect Dis Rep2008，10，3： | 1 |
| 6 | The sum of log-normal probability distribution in scattertransmission system 显示文摘 | FENTON L F | 1960 | IEEE Trans on Communications Sys-tems1960，8，1： | 1 |
| 7 | Malignant astrocytic glioma: genetics, biology, and paths to treatment 显示文摘 | FURNARI F B FENTON T BACHOO R M | 2007 | Genes Dev2007，21，21： | 1 |
| 8 | The sum of log-normal probability distributions in scatter transmission systems 显示文摘 | FENTON L F | 1960 | IEEE Transactions on Communications Systems1960，8，1： | 1 |
| 9 | Anterior urethral strictures:etiology and characteristics显示文摘 | FENTON A S MOREY A F AVILES R | 2005 | Urology2005，65，6： | 1 |
| 10 | Association between bipolar disorder and monoamine oxidase A gene polymorphisms: results of a multicenter study 显示文摘 | Preising M Bellivier F Fenton BT | 2000 | Am J Psychiatry2000，157，6： | 1 |
| 11 | Multiple mechanisms of spiral wave breakup in a model of cardiac electrical activity显示文摘 | Fenton F H Cherry E M Hastings H M | | 0，，03： | 1 |
| 12 | Psychiatric symptom pro- files of patients with epilepsy: a controlled investigation 显示文摘 | Standage K F Fenton G W | 1975 | Psychol Med1975，5，2： | 1 |
| 13 | Thrombin and antithrombotics显示文摘 | Fenton J W 2nd Ofosu F A Brezniak D V | 1998 | Semin Thromb Hemost1998，24，2： | 1 |
| 14 | The sum of log-normal probability distributions in scatter transmission systems显示文摘 | FENTON L F | 1960 | IRE Transactions on Communications Systems1960，8，1： | 1 |
| 15 | Spatiotemporal control of wave instabilities in cardiac tissue显示文摘 | Rappel W J Fenton F Karma A | 1999 | Phys Rev Lett1999，83，： | 1 |
| 16 | Adenosine reduces the Ca2+transients of isoproternol-stimulated rat ventricular myo-cytes显示文摘 | Fenton R A Moore E D Fay F S | 1991 | Am J Physiol1991，261，1： | 1 |
| 17 | Mechanism for discordant alternans显示文摘 | FENTON F H EVANS S J | 2001 | J Cardiovasc Electrophysiol2001，12，2： | 1 |
| 18 | Malignant astrocytie glioma: genetics, biology and paths to treatment显示文摘 | Furnan F B Fenton T Bachoo R M | 2007 | Genes Dev2007，21，21： | 1 |
| 19 | Thrombin inhibition by hirudin:how hirudin inhibits thrombin显示文摘 | FENTON J W VILLANUEVA G B OFOSU F A | 1991 | Haemostasis1991，21，1： | 1 |
| 20 | Evaluation of microregional variations in tumor hypoxia following the administration of endostatin显示文摘 | Fenton B M Paoni S F Beauchamp B K | 2003 | Adv Exp Med Biol2003，510，： | 1 |
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