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| 1 | Epithelial toll-like receptor 9 signaling in colorectal inflammation and cancer: Clinico-pathogenic aspects显示文摘Toll-like receptors (TLRs) recognize specific motifs which are frequently present in bacteria, fungi, prokaryotes and viruses. Amongst TLRs, TLR9 can be activated by such bacterial or viral DNA fragments, immunoglobulin-DNA complexes or synthetic oligonucleotides, which all contain unmethylated cytosineguanine nucleotide sequences (CpGs). Emerging data indicate that TLR9 signaling has a role in, and may influence, colorectal carcinogenesis and colonic inflammation. CpGs are classified into three groups according to their influence on both the antigen-specific humoraland cellular immunity, and the production of type 1 interferons and proinflammatory cytokines. TLR9 activation via CpGs may serve as a new therapeutic target for several cancerous and various inflammatory conditions. Due to its probable anti-cancer effects, the application possibilities of TLR9-signaling modulation may be extremely diverse even in colorectal tumors. In this review we aimed to summarize the current knowledge about TLR-signaling in the pathogenesis and therapy of inflammatory bowel diseases and colorectal cancer. Due to the species-specific differences in TLR9 expression, however, one must be careful in translating the animal model data into the human system, because of the differences between CpG-oligodeoxynucleotide-responsive cells. TLR9 agonist DNA-based immunomodulatory sequences could also represent a promising therapeutic alternative in systemic inflammatory conditions and chronic colonic inflammations as their side effects are not significant. | István Fri Ferenc Sipos Tiana M Germann Alexandra Kalmár Zsolt Tulassay Béla Molnár Gyrgyi Mzes | 2013 | World Journal of Gastroenterology2013，19，26： | 14 |
| 2 | Contribution of TLR signaling to the pathogenesis of colitisassociated cancer in inflammatory bowel disease显示文摘In the intestine a balance between proinflammatory and repair signals of the immune system is essential for the maintenance of intestinal homeostasis. The innate immunity ensures a primary host response to microbial invasion, which induces an inflammatory process to localize the infection and prevent systemic dissemination of pathogens. The key elements of this process are the germline encoded pattern recognition receptors inclu-ding Toll-like receptors(TLRs). If pathogens cannot be eliminated, they may elicit chronic inflammation, which may be partly mediated via TLRs. Additionally, chronic inflammation has long been suggested to trigger tissue tumorous transformation. Inflammation, the seventh hallmark of cancer, may affect all phases of tumor development, and evade the immune system. Inflammation acts as a cellular stressor and may trigger DNA damage or genetic instability. Furthermore, chronic inflammation can provoke genetic mutations and epigenetic mechanisms that promote malignant cell transformation. Colorectal cancers in inflammatory bowel disease patients are considered typical examples of inflammation-related cancers. Although data regarding the role of TLRs in the pathomechanism of cancer-as-sociated colitis are rather conflicting, functionally these molecules can be classified as 'largely antitumorigenic' and 'largely pro-tumorigenic' with the caveat that the underlying signaling pathways are mainly context(i.e., organ-, tissue-, cell-) and ligand-dependent. | Ferenc Sipos István Fri Miklós Constantinovits Zsolt Tulassay Gyrgyi Mzes | 2014 | World Journal of Gastroenterology2014，20，36： | 9 |
| 3 | Early on-treatment prediction of response to peginterferon alfa-2a for HBeAg-negative chronic hepatitisB using HBsAg and HBV DNA levels 显示文摘 | Rijckborst V Hansen BE Cakaloglu Y Ferenci P Tabak F Akdogan M Simon K Akarca US Flisiak R Verhey E Van Vuuren AJ Boucher CA ter Borg MJ Janssen HL | 2010 | Hepatology2010，52，2： | 1 |
| 4 | Managing the career plateau显示文摘 | Ference T P Stoner J A F Warren E K | 1977 | Academy of Management Review1977，，2： | 1 |
| 5 | Early on-treatment prediction of response to peginterferon alfa-2a for HBeAg-negative chronic hepatitis B using HBsAg and HBV DNA levels 显示文摘 | Rijckborst V Hansen BE Cakaloglu Y Ferenci P Tabak F Akdogan M Simon K Akarca US Flisiak R Verhey E Van Vuuren AJ Boucher CA ter Borg MJ Janssen HL | 2010 | Hepatology2010，52，2： | 1 |
| 6 | Complete inhibition of P- gly- coprotein by simultaneous treatment with a distinct class of modu- lators and the UIC2 monoclonal antibody显示文摘 | Katalin G Ferenc F Zsoh B | 2007 | J Pharm Exp Ther2007，320，1： | 1 |
| 7 | Determination of saquinavir in human plasma by high-performance liquid chroatography显示文摘 | HUY R H FERENC F YVONNE B | 1997 | J Chromatogr B1997，694，： | 1 |
| 8 | Circulating and cardiac levels of apelin,the novel ligand of the orphan receptor APJ,in patients with heart failure显示文摘 | Gábor F Ferenc H István S | 2003 | Biochem Biophys Res Commun2003，308，3： | 1 |
| 9 | Newer treatments for decompensated heart failure:Focus on levosimendan显示文摘 | Ferenc F | 2009 | Drug Des Devel Ther2009，3，： | 1 |
| 10 | Circulating and cardiac levels of apelin, the novel ligand of the orphan receptor APJ, in patients with heart failure 显示文摘 | G bor F Ferenc H Istv n S | 2003 | Biochem and Biophys Research Communi2003，308，3： | 1 |
| 11 | Synthesis and ring-chain tautomerism of stereoisomeric 1,3-oxazines condensed with the cyclopentane ring显示文摘 | Ferenc F Kalevi P Jorma M | 1987 | Tetrahedron1987，43，8： | 1 |
| 12 | Classeeic preconditioning decrease the harmful accumulation of nitric oxied during ischemia and reperfusionin rat hearts显示文摘 | Csaba C Zoltan S Ference F | 1999 | Circulation1999，100，22： | 1 |
| 13 | Manufacturing synthesis of5-substituted phthalides显示文摘 | Ferenc F Angelika T Balazs al | 2010 | Org Process Res Dev2010，14，3： | 1 |
| 14 | Telaprevir for retreatment of HCV infection 显示文摘 | Zeuzem S Andreone P Pol S Lawitz E Diago M Roberts S Foeaccia R Younossi Z Foster GR Horban A Ferenci P Nevens F Mullhaupt B Pockros P Terg R Shouval D van Hoek B Weiland O Van Heeswijk R De Meyer S Luo D Boogaerts G Polo R Picchio G Beumont M REALIZE Study Team | 2011 | N Engl J Med2011，364，25： | 1 |
| 15 | Enzymatic method for the synthesis of blockbuster drug intermediates-synthesis of five-membered cyclic -v-amino acid and -y-lactam enantiomers 显示文摘 | ENIKO F FERENC F | 2008 | Eur J Org Chem2008，31，2008： | 1 |
| 16 | Classic precondi-tioning decrease the harmful accumulation of nitric oxide during ischemia and reperfusion in rat hearts 显示文摘 | Csonka C Zohan S Ferenc F | 1999 | Circulation1999，100，22： | 1 |
| 17 | classeelc preconditioning decrease the harmful accumulation of nitric oxide during ischemia and reperfusion in rat hearts显示文摘 | Csaba c Zoltan s Ference F | 1999 | Circulation1999，100，2： | 1 |
| 18 | Newer treatments for deeompensated heart failure: focus on levosi- mendan显示文摘 | Ferenc F | 2009 | Drug Des Devel2009，3，： | 1 |
| 19 | Managing the career plateau显示文摘 | Ference T P Stoner J A F Warren E K | 1977 | Academy of Management Review1977，，2： | 1 |
| 20 | Telaprevir for retreatment of HCV infection显示文摘 | Zeuzem S Andreone P Pol S Lawitz E Diago M Roberts S Focaccia R Younossi Z Foster G R Horban A Ferenci P Nevens F Müllhaupt B Pockros P Terg R Shouval D Hoek B Weiland O Heeswijk R Meyer S Luo D Boogaerts G Polo R Picchio G Beumont M | 2011 | N Engl J Med2011，364，25： | 1 |
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