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| 1 | Urinary 11-dehydro thromboxane B 2 levels in type 2 diabetic patients before and during aspirin intake显示文摘 | Lillian Harboe Gon?alves Luci Maria Sant'Ana Dusse Ana Paula Fernandes Karina Braga Gomes Mirelle Oliveira Sóter Michelle Teodoro Alves Kathryna Fontana Rodrigues Fernanda Rocha Freitas Flavia Komatsuzaki Marinez Oliveira Sousa Adriana Aparecida Bosco Gér | 2011 | Clinica Chimica Acta2011，，15： | 1 |
| 2 | Use of UHP- FRC overlay to Reduce Stress in Orthotropie Steel Decks 显示文摘 | Lamine Dieng Pierre Marchand Fernanda Gomes Christian Tessier Francois Toutlemonde | 2013 | Journal of Constructional Steel Research2013，89，7： | 1 |
| 3 | Association of microparticles and preeclampsia显示文摘 | Fabiana K. Marques Fernanda M. F. Campos Lirlandia P. Sousa Andréa Teixeira-Carvalho Luci M. S. Dusse Karina B. Gomes | 2013 | Molecular Biology Reports2013，，7： | 1 |
| 4 | ID7 Isolated from Bauhinia variegata Stem Inhibits Tumor Progression and Metastatic Mechanisms of Triple Negative Breast Cancer in Vivo显示文摘Background:The breast cancer has been the most common form of cancer among women.The triple negative subtype represents 20%of all breast cancer cases in the world and is standing out by affecting young women and being aggressive.The main cause of death of patients with cancer is due to metastasis,which can reach the liver and lungs.Objective:The activities of ID7 fraction of the stems of Bauhinia variegata L.on breast cancer,lung metastasis and liver inflammatory process were evaluated.Method:ID7 was characterized by mass-spectrometry.The viability of murine mammary cells(4T1)treated with ID7 was assessed by MTT,trypan blue and fluorescence assay and viability of BT-20,MDA-MB-231 and MCF-7 human breast cancer tumor lines by MTS.The cell migration,invasion using matrigel and adhesion were performed.The expression of cell death proteins was quanitified by western blot and the gelatinases by zimogram.The ID7 activity of the tumor(4T1)and metastatic progession in vivo was evaluated.Results:ID7 reduced the 4T1 and MDA-MB-231viability and increased the late apoptosis,inhibited the 4T1 migration and invasion,increased the 4T1 adhesion and decreased the secreted active gelatinases.ID7 also increased the expression of PARP,caspase-7 and caspase-8,RIP and TNF-R1.In vivo,the ID7 decreased the volume and weight of the tumors and decreased lung metastasis and inflammation in the liver.The characterization showed mainly the presence of oleic acid,myricetin,quercetin and kaempferol in ID7.Conclusion:Thus,it was found that ID7 fraction exhibits selective antitumor and on the mechanisms of breast cancer metastasis activity,preventing lung metastasis and inflammation in the liver.It is suggested that fatty acids and flavonoids are correlated with such activities. | Kamilla Monteiro dos Santos Izabela Natalia Faria Gomes Renato JoséSilva Oliveira Fernanda E.Pinto Bruno Oliveira Fabrício P.Batista Rafael Cesar Russo Chagas Hélio B.Santos Ralph G.Thomé Wanderson Romao Rui Manuel Reis Maria Luiza Vilela Oliva Rosy Iara Maciel de Azambuja Ribeiro | 2019 | Journal of Pharmacy and Pharmacology2019，7，7： | 1 |
| 5 | JAK2 V617F Mutation in Patients with Splanchnic Vein Thrombosis显示文摘 | Sandra Guerra Xavier Telma Gadelha Glicínia Pimenta Angela Maria Eugenio Daniel Dias Ribeiro Fernanda Mendes Gomes Martin Bonamino Ilana Renault Zalcberg Nelson Spector | 2010 | Digestive Diseases and Sciences2010，，6： | 1 |
| 6 | Preliminary analysis of miRNA pathway in Schistosoma mansoni显示文摘 | Matheus S. Gomes Fernanda J. Cabral Liana K. Jannotti-Passos Omar Carvalho Vanderlei Rodrigues Elio H. Baba Renata G. Sá | 2008 | Parasitology International2008，，1： | 1 |
| 7 | CYP1A1,CYP2E1 and EPHX1 polymorphisms in sporadic colorectal neoplasms显示文摘AIM To investigate the contribution of polymorphisms in the CYP1A1, CYP2E1 and EPHX1 genes on sporadic colorectal cancer(SCRC) risk. METHODS Six hundred forty-one individuals(227 patients with SCRC and 400 controls) were enrolled in the study. The variables analyzed were age, gender, tobacco and alcohol consumption, and clinical and histopathological tumor parameters. The CYP1A1 *2A, CYP1A1 *2C CYP2E1 *5B and CYP2E1 *6 polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP). The EPHX1 Tyr113 His, EPHX1 His139 Arg and CYP1A1 *2C polymorphisms were detected by real-time PCR. Chisquared test and binary logistic regression were used in the statistical analysis. Haplotype analysis was conducted using the Haploview program, version 2.05.RESULTS Age over 6 2 years was a risk factor for SCRC development(OR = 7.54, 95%CI: 4.94-11.50, P < 0.01). Male individuals were less susceptible to SCRC(OR = 0.55, 95%CI: 0.35-0.85, P < 0.01). The CYP2E1*5B polymorphism was associated with SCRC in the codominant(heterozygous genotype: OR = 2.66, 95%CI: 1.64-4.32, P < 0.01), dominant(OR = 2.82, 95%CI: 1.74-4.55, P < 0.01), overdominant(OR = 2.58, 95%CI: 1.59-4.19, P < 0.01), and log-additive models(OR = 2.84, 95%CI: 1.78-4.52, P < 0.01). The CYP2E1*6 polymorphism was associated with an increased SCRC risk in codominant(heterozygous genotype: OR = 2.81, 95%CI: 1.84-4.28, P < 0.01; homozygous polymorphic : OR = 7. 3 2, 9 5 % C I : 1.85-28.96, P < 0.01), dominant(OR = 2.97, 95%CI: 1.97-4.50, P < 0.01), recessive(OR = 5.26, 95%CI: 1.35-20.50, P = 0.016), overdominant(OR = 2.64, 95%CI: 1.74-4.01, P < 0.01), and log-additive models(OR = 2.78, 95%CI: 1.91-4.06, P < 0.01). The haplotype formed by the minor alleles of the CYP2E1*5B(C) and CYP2E1*6(A) polymorphisms was associated with SCRC(P = 0.002). However, the CYP1A1 *2A, CYP1A1 *2C, EPHX1 Tyr113 His and EPHX1 His139 Arg polymorphisms were not associated with SCRC.CONCLUSION In conclusion, the results demonstrated that CYP2E1*5B and CYP2E1*6 minor alleles play a role in the development of SCRC. | Glaucia Maria M Fernandes Anelise Russo Marcela Alcantara Proenca Nathalia Fernanda Gazola Gabriela Helena Rodrigues Patrícia Matos Biselli-Chicote Ana Elizabete Silva Joao Gomes Netinho érika Cristina Pavarino Eny Maria Goloni-Bertollo | 2016 | World Journal of Gastroenterology2016，22，45： | 1 |
| 8 | Animal models applied to acute-on-chronic liver failure:Are new models required to understand the human condition?显示文摘The liver is a multifaceted organ;its location and detoxifying function expose this organ to countless injuries.Acute-on-chronic failure liver(ACLF)is a severe syndrome that affects the liver due to acute decompensation in patients with chronic liver disease.An infection environment,ascites,increased liver enzymes and prothrombin time,encephalopathy and fast-evolving multiorgan failure,leading to death,usually accompany this.The pathophysiology remains poorly understand.In this context,animal models become a very useful tool in this regard,as understanding;the disease may be helpful in developing novel therapeutic methodologies for ACLF.However,although animal models display several similarities to the human condition,they do not represent all ACLF manifestations,resulting in significant challenges.An initial liver cirrhosis framework followed by the induction of an acute decompensation by administering lipopolysaccharide and D-Ga IN,potentiating liver damage supports the methodologies applied to induce experimental ACLF.The entire methodology has been described mostly for rats.Nevertheless,a quick Pub Med database search indicates about 30 studies concerning ACFL models and over 1000 regarding acute liver failure models.These findings demonstrate the clear need to establish easily reproducible ACFL models to elucidate questions about this quickly established and often fatal syndrome. | Jaciara Fernanda Gomes Gama Liana Monteiro da Fonseca Cardoso Jussara Machado Lagrota-Candido LuizAnastacio Alves | 2022 | World Journal of Clinical Cases2022，10，9： | 1 |
| 9 | Product-service systems: a literature review on integrated products and services显示文摘 | Fernanda H?nsch Beuren Marcelo Gitirana Gomes Ferreira Paulo A. Cauchick Miguel | 2013 | Journal of Cleaner Production2013，，： | 1 |
| 10 | Synthesis, characterization and evaluation of sulfonic resins as catalysts显示文摘 | Fernanda M.B Coutinho Rosane R Souza Ailton S Gomes | 2004 | European Polymer Journal2004，，7： | 1 |
| 11 | Coronal sulcus-based ventral mucosal flap to help penile coverage in severe concealed penis显示文摘Introduction There are many techniques to treat congenital concealed penis(CP).Skin resurfacing is the most difficult step in severe cases.We aim to show medium-term results of coronal sulcus-based triangular ventral mucosal flap(CBVMF)as a treatment of prepubertal severe CP,a recently reported technique.We aim to determine whether results are durable and if the technique is associated with persistent mucosal redundancy or with a permanent unequal penile color pattern.Methods CP cases reconstructed with CBVMF were reviewed.Preoperative complaints,degree of motivation of the child/parent to surgery,satisfaction of parent/child with results,and surgical complications were described.Results Seven patients(6 months to 6 years old)were treated with CBVMP.Two patients showed megaprepuce and another was submitted to a limited postectomy 3 years before.One family was not fully satisfied(expected“bigger penis”),but acknowledged that the penis was now well exposed.No child talked about the problem preoperatively,but all of the boys were fully satisfied with the results of the surgery and verbalized this in the interviews.Flap edema resolved after 3 months in all but one patient.The flaps assumed the color of penile skin in the medium term.Conclusions CBMVP results were satisfactory.Serious complications did not occur.Flap edema does not persist in the medium term,and redundancy was not a problem.The color of the flap tended to evolve into a pattern similar to the penile skin. | Lisieux Jesus Flavia Amaro Jamel Fernanda Gomes Talia Dias Ribeiro Samuel Dekermacher | 2021 | World Journal of Pediatric Surgery2021，4，3： | 0 |
| 12 | Elevated calprotectin levels are associated with mortality in patients with acute decompensation of liver cirrhosis显示文摘BACKGROUND Acute decompensation(AD)of cirrhosis is related to systemic inflammation and elevated circulating cytokines.In this context,biomarkers of inflammation,such as calprotectin,may be of prognostic value.AIM To evaluate serum calprotectin levels in patients hospitalized for complications of cirrhosis.METHODS This is a prospective cohort study that included 200 subjects hospitalized for complications of cirrhosis,20 outpatients with stable cirrhosis,and 20 healthy controls.Serum calprotectin was measured by enzyme-linked immunosorbant assay.RESULTS Calprotectin levels were higher among groups with cirrhosis when compared to healthy controls.Higher median calprotectin was related to Child-Pugh C,ascites,and hepatic encephalopathy.Higher calprotectin was related to acute-on-chronic liver failure(ACLF)and infection in the bivariate,but not in multivariate analysis.Calprotectin was not associated with survival among patients with ACLF;however,in patients with AD without ACLF,higher calprotectin was associated with a lower 30-d survival,even after adjustment for chronic liver failure-consortium(CLIF-C)AD score.A high-risk group(CLIF-C AD score≥60 and calprotectin≥580 ng/mL)was identified,which had a 30-d survival(27.3%)similar to that of patients with grade 3 ACLF(23.3%).CONCLUSION Serum calprotectin is associated with prognosis in patients with AD without ACLF and may be useful in clinical practice to early identify patients with a very low short-term survival. | Camila Matiollo Elayne Cristina de Morais Rateke Emerita Quintina de Andrade Moura Michelle Andrigueti Fernanda Cristina de Augustinho Tamara Liana Zocche Telma Erotides Silva Lenyta Oliveira Gomes Mareni Rocha Farias Janaina Luz Narciso-Schiavon Leonardo Lucca Schiavon | 2022 | World Journal of Hepatology2022，14，11： | 0 |
| 13 | Genotype-environment interaction in Cordia trichotoma(Vell.)Arráb.Ex Steud.progenies in two different soil conditions显示文摘Investment in silvicultural techniques is noticeably lacking,especially in breeding programs for non-conventional wood species.Studying genotype×environment interaction(G×E)is essential to the development of breeding programs.Thus,this study aimed to estimate genetic diversity of and the effects of G×E interaction on two progeny tests of Cordia trichotoma,including the estimation of genetic gain and genetic diversity after selection.For the experiment,30 progenies of C.trichotoma were tested at two sites with differing soil textures.Diameter at breast height(1.30 m above soil surface,dbh-cm),total height,diameter at 30 cm from the soil,first branch height,and survival were all monitored for four years.Statistical deviance,best linear unbiased estimator,and harmonic mean of relative performance of genetic values(MHPRVG)were all calculated to predict breeding values,estimate genetic parameters,and analyze deviance.All quantified traits varied significantly among progenies by soil type,with greatest variation recorded for genetic variability.Heritability of the progenies led to predictions of genetic gain,ranging from 7.73 to 15.45%,for dbh at four years of age.The calculated decrease in genetic diversity after selection showed that this parameter should be monitored in subsequent breeding cycles.G×E was low for all tests.The best-performing progenies proved most stable and best adapted to the different environmental conditions tested. | Wanderley dos Santos Bruno Marchetti de Souza Daniele Fernanda Zulian Gilberto Terra Ribeiro Alves João Bosco Vasconcellos Gomes Mário Luiz Teixeira de Moraes Valderês Aparecida de Sousa Ananda Virginia de Aguiar | 2022 | Journal of Forestry Research2022，33，1： | 0 |
| 14 | Overweight and abdominal fat are associated with normal bone mineral density in patients with ulcerative colitis显示文摘BACKGROUND Low bone mineral density(BMD)is common in patients with inflammatory bowel disease.However,nutritional risk factors for low BMD in the ulcerative colitis(UC)population are still poorly understood.AIM To investigate the association of anthropometric indicators and body composition with BMD in patients with UC.METHODS This is a cross-sectional study on adult UC patients of both genders who were followed on an outpatient basis.A control group consisting of healthy volunteers,family members,and close people was also included.The nutritional indicators evaluated were body mass index(BMI),total body mass(TBM),waist circumference(WC),body fat in kg(BFkg),body fat in percentage(BF%),trunk BF(TBF),and also lean mass.Body composition and BMD assessments were performed by dual-energy X-ray absorptiometry.RESULTS The sociodemographic characteristics of patients with UC(n=68)were similar to those of healthy volunteers(n=66)(P>0.05).Most patients(97.0%)were in remission of the disease,58.8%were eutrophic,33.8%were overweight,39.0%had high WC,and 67.6%had excess BF%.However,mean BMI,WC,BFkg,and TBF of UC patients were lower when compared to those of the control group(P<0.05).Reduced BMD was present in 41.2%of patients with UC(38.2%with osteopenia and 2.9%with osteoporosis)and 3.0%in the control group(P<0.001).UC patients with low BMD had lower BMI,TBM,and BFkg values than those with normal BMD(P<0.05).Male patients were more likely to have low BMD(prevalence ratio[PR]=1.86;95%confidence interval[CI]:1.07-3.26).Those with excess weight(PR=0.43;95%CI:0.19-0.97)and high WC(PR=0.44;95%CI:0.21-0.94)were less likely to have low BMD.CONCLUSION Patients with UC in remission have a high prevalence of metabolic bone diseases.Body fat appears to protect against the development of low BMD in these patients. | Mirella Brasil Lopes Andre Castro Lyra Raquel Rocha Fernanda Gomes Coqueiro Carla Andrade Lima Carolina Cunha de Oliveira Genoile Oliveira Santana | 2022 | World Journal of Gastrointestinal Pharmacology and Therapeutics2022，13，4： | 0 |
| 15 | 空间、环境和历史因素对热带森林树种周转的影响显示文摘本文通过回答以下问题来分析空间距离、当前和过去的环境差异及这几个因素对树木群落分类和系统发育转换的影响:(i)树木群落分类和系统发育转换是否与空间距离通过环境差异产生的间接影响相关?(ii)树木群落分类和系统发育转换是否随古气候(末次盛冰期和中全新世)的变化而变化?本文对巴西的14个大西洋雨林样点(采样面积20.4 ha)83个科615个种进行了研究,获得了当前、中全新世和末次盛冰期的地块地理坐标、土壤变量和样点生物气候变量。我们使用基于距离的结构方程模型(SEM)来(i)检测空间距离和环境差异的直接影响,以及(ii)检测空间距离通过环境差异对分类(Bray-Curtis距离)和系统发育转换(Comdist和Comdistnt距离)的间接影响。研究结果表明,空间距离通过环境差异对分类和系统发育转换的间接影响较弱。基于生态位中性的历史过程带来的直接影响驱动了树木群落的转换。因此,我们推断古气候(历史过程)促进了产生当前植物区系分支的选择,而空间距离(中性的过程)限制了物种从区域种库向外扩散的范围,环境条件(基于生态位的过程)则在本地选择能够持续生存的分类群。 | Alisson Borges Miranda Santos Vinicius Andrade Maia Cleber Rodrigo de Souza Nathalle Cristine Alencar Fagundes Fernanda Moreira Gianasi Aurelio de Jesus Rodrigues Pais Natalia de Aguiar-Campos Gabriela Gomes Pires Diego Teixeira Girardelli Jean Daniel Morel Mariana Caroline Moreira Morelli Felipe de Carvalho Araujo Rubens Manoel dos Santos | 2021 | Journal of Plant Ecology2021，14，4： | 0 |
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