|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Clinical and pathological characterization of epstein-barr virus-associated gastric carcinomas in portugal显示文摘AIM To determine the prevalence of epstein-barr virus(eb V)-associated gastric carcinomas in the North Region of Portugal and to study its clinicopathological characteristics. METHODS We have performed a retrospective study including a total of 179 consecutive patients with gastric cancer(GC) submitted to gastrectomy during 2011 at the Portuguese Oncology Institute of Porto. Clinical and pathological data was collected from individual clinical records and inserted on a database with unique codification. Tumour tissues were collected from the institutional tumour bank. eb V was detected by in situ hybridization for the detection of eb V-encoded small RNAs(ebe Rs) and eb V latent proteins(LMP1 and LMP2 A) were detected by immunohistochemistry.RESULTS The analysis showed that eb V-associated gastric carcinomas(eb Va GC) represents 8.4%(15/179) of all GC cases, with a significant differential distribution among histological types(P < 0.001): 100%(3/3) of medullary carcinomas, 100%(1/1) of adenosquamous carcinoma, 8.7%(8/92) of tubular adenocarcinomas, 8.0%(2/25) of mixed carcinomas and 2%(1/51) in poorly cohesive carcinomas. The analysis revealed a higher predominance of eb Va GC in the upper third and middle(cardia, fundus and body) of the stomach(P = 0.041), a significant lower number of regional lymph nodes invasion(P = 0.025) and a tendency for better prognosis(P = 0.222). eb V latent protein expression revealed that all eb Va GC cases were LMP1-negative, nevertheless 6 cases(40%) expressed LPM2 A, which reveals that these cases show a distinct eb V-Latency profile(latency II-like).CONCLUSION eb Va GC represents 8.4% of all GC in the North Region of Portugal. The eb V-infected patients have specific clinic-pathological features that should be further explored to develop new strategies of management and treatment. | Joana Ribeiro Andreia Oliveira Mariana Malta Claudia Oliveira Fernanda Silva Ana Galaghar Luís Pedro Afonso Maria Cassiano Neves Rui Medeiros Pedro Pimentel-Nunes Hugo Sousa | 2017 | World Journal of Gastroenterology2017，23，40： | 9 |
| 2 | Urinary 11-dehydro thromboxane B 2 levels in type 2 diabetic patients before and during aspirin intake显示文摘 | Lillian Harboe Gon?alves Luci Maria Sant'Ana Dusse Ana Paula Fernandes Karina Braga Gomes Mirelle Oliveira Sóter Michelle Teodoro Alves Kathryna Fontana Rodrigues Fernanda Rocha Freitas Flavia Komatsuzaki Marinez Oliveira Sousa Adriana Aparecida Bosco Gér | 2011 | Clinica Chimica Acta2011，，15： | 1 |
| 3 | Mathematical modeling of the kinetic of quality deterioration of intermediate moisture content banana during storage显示文摘 | Yan Zheng - yong Sousa - Gallagher Maria J Fernanda A R Oliveira | 2008 | Journal of Food Engineering2008，84，3： | 1 |
| 4 | Association of microparticles and preeclampsia显示文摘 | Fabiana K. Marques Fernanda M. F. Campos Lirlandia P. Sousa Andréa Teixeira-Carvalho Luci M. S. Dusse Karina B. Gomes | 2013 | Molecular Biology Reports2013，，7： | 1 |
| 5 | Oral sensorimotor function for feeding in patients with tetanus显示文摘 | Laura Davison Mangilli Fernanda Chiarion Sassi Sigrid De Sousa Dos Santos | 2009 | Acta Tropica2009，111，3： | 1 |
| 6 | Chagas heart disease:An overview of diagnosis,manifestations,treatment,and care显示文摘Chagas heart disease(CHD)affects approximately 30%of patients chronically infected with the protozoa Trypanosoma cruzi.CHD is classified into four stages of increasing severity according to electrocardiographic,echocardiographic,and clinical criteria.CHD presents with a myriad of clinical manifestations,but its main complications are sudden cardiac death,heart failure,and stroke.Importantly,CHD has a higher incidence of sudden cardiac death and stroke than most other cardiopathies,and patients with CHD complicated by heart failure have a higher mortality than patients with heart failure caused by other etiologies.Among patients with CHD,approximately 90%of deaths can be attributed to complications of Chagas disease.Sudden cardiac death is the most common cause of death(55%–60%),followed by heart failure(25%–30%)and stroke(10%–15%).The high morbimortality and the unique characteristics of CHD demand an individualized approach according to the stage of the disease and associated complications the patient presents with.Therefore,the management of CHD is challenging,and in this review,we present the most updated available data to help clinicians and cardiologists in the care of these patients.We describe the clinical manifestations,diagnosis and classification criteria,risk stratification,and approach to the different clinical aspects of CHD using diagnostic tools and pharmacological and non-pharmacological treatments. | Roberto M Saraiva Mauro Felippe F Mediano Fernanda SNS Mendes Gilberto Marcelo Sperandio da Silva Henrique H Veloso Luiz Henrique C Sangenis Paula Simplício da Silva Flavia Mazzoli-Rocha Andréa S Sousa Marcelo T Holanda Alejandro M Hasslocher-Moreno | 2021 | World Journal of Cardiology2021，13，12： | 1 |
| 7 | Essential Competences to the Pharmacy Industry Competitivity: Case Study With Cooperators in the Town of Natal, Rio Grande do Norte, Brazil显示文摘 | Kleber Cavalcante de Sousa Fernanda Cristina Barbosa Pereira Queiroz Helio Roberto Hekis Jamerson Viegas Queiroz Marciano Furukava | 2013 | China-USA Business Review2013，12，9： | 0 |
| 8 | Ascorbic acid improves impaired venous and arterial endotheliumdependent dilation in smokers显示文摘Aim: To compare the acute effects of ascorbic acid on vasodilation of veins and arteries in vivo. Methods: Twenty-six healthy non-smokers and 23 healthy moderate smokers were recruited in this study. The dorsal hand vein compliance technique and flow-mediated dilation were used. Dose-response curves to bradykinin and sodium nitroprusside were constructed to test the endothelium-dependent and -independent relaxation before and after acute infusion of ascorbic acid. Results: Smokers had an impaired venodilation with bradykinin compared with non-smokers (68.3%±13.2% vs 93.7%±20.1%, respectively; P<0.05). Ascorbic acid administration in the dorsal hand vein significantly increased the venodilation with bradykinin in smokers (68.3%±13.2% vs 89.5%±6.3% before and after infusion,respectively; P<0.05) but not in non-smokers (93.7%±20.1% vs 86.4%±12.4% before and after infusion, respectively). Similarly, the arterial response in smokers had an impaired endothelium-dependent dilation compared with that in non-smokers (8.8%±2.7% vs 15.2%±2.3%, respectively; P<0.05) and ascorbic acid restored this response in smokers (8.8%±2.7% vs 18.7%±6.5% before and after infusion, respectively; P<0.05), but no difference was seen in non-smokers (15.2%±2.3% vs 14.0%±4.4% before and after infusion, respectively). The endothelium-independent dilation did not differ in both the groups studied. No important hemodynamic change was detected using the Portapress device. Conclusion: Smokers had impaired endothelium-dependent vasodilation responsiveness in both arterial and venous systems. Ascorbic acid restores this responsiveness in smokers. | Márcio Goncalves de SOUSA Juan Carlos YUGAR-TOLEDO Marcelo RUBIRA Sílvia Elaine FERREIRA-MELO Rodrigo PLENTZ Deise BARBIERI Fernanda CONSOLIM-COLOMBO Maria Cláudia IRIGOYEN Heitor MORENO Jr | 2005 | Acta Pharmacologica Sinica2005，26，4： | 0 |
| 9 | Genotype-environment interaction in Cordia trichotoma(Vell.)Arráb.Ex Steud.progenies in two different soil conditions显示文摘Investment in silvicultural techniques is noticeably lacking,especially in breeding programs for non-conventional wood species.Studying genotype×environment interaction(G×E)is essential to the development of breeding programs.Thus,this study aimed to estimate genetic diversity of and the effects of G×E interaction on two progeny tests of Cordia trichotoma,including the estimation of genetic gain and genetic diversity after selection.For the experiment,30 progenies of C.trichotoma were tested at two sites with differing soil textures.Diameter at breast height(1.30 m above soil surface,dbh-cm),total height,diameter at 30 cm from the soil,first branch height,and survival were all monitored for four years.Statistical deviance,best linear unbiased estimator,and harmonic mean of relative performance of genetic values(MHPRVG)were all calculated to predict breeding values,estimate genetic parameters,and analyze deviance.All quantified traits varied significantly among progenies by soil type,with greatest variation recorded for genetic variability.Heritability of the progenies led to predictions of genetic gain,ranging from 7.73 to 15.45%,for dbh at four years of age.The calculated decrease in genetic diversity after selection showed that this parameter should be monitored in subsequent breeding cycles.G×E was low for all tests.The best-performing progenies proved most stable and best adapted to the different environmental conditions tested. | Wanderley dos Santos Bruno Marchetti de Souza Daniele Fernanda Zulian Gilberto Terra Ribeiro Alves João Bosco Vasconcellos Gomes Mário Luiz Teixeira de Moraes Valderês Aparecida de Sousa Ananda Virginia de Aguiar | 2022 | Journal of Forestry Research2022，33，1： | 0 |
| 10 | Pleistocene Birds of Gruta Nova da Columbeira(Bombarral-Portugal):A Paleontological and Paleoenvironmental Aproach显示文摘Discovered in 1962,the Columbeira cave has a Mousterian sequence dated between 101 and 35 Ka(U-series)and between 28,900 and 18,000 BP 14C.Excavations recovered abundant lithic implements and provided rich assemblage of vertebrates,including mammals,reptiles,birds and a remain of Homo neanderthalensis.In this work,authors present the taxonomy at the level of genus and species of the bird assemblage and its possible relationship with the paleoenvironments in which they lived.Thirteen species of birds have been identified out of 283 bones.Most of these bones are very fragmented and unsuitable for identification down to species or the genus level.Nevertheless,it is possible to say that the species vary through the sequence and that the assemblage is dominated by Pyrrhocorax,Corvus,Columba Turdus and Alectoris. | Silvério D. Figueiredo Fernanda Sousa Solange Silva Luís Raposo Telmo Pereira Américo Rosa | 2018 | Journal of Environmental Science and Engineering(A)2018，7，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员