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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Early surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the International Surgical Trial in Intracerebral Haemorrhage (STICH): a randomised trial显示文摘 | A David Mendelow Barbara A Gregson Helen M Fernandes Gordon D Murray Graham M Teasdale D Terence Hope Abbas Karimi M Donald M Shaw David H Barer | 2005 | 2005 (9457)2005，，9457： | 2 |
| 3 | Characterization of Pore Systems in Seal Rocks Using Nitrogen Gas Adsorption Combined with Mercury Injection Capillary Pressure Techniques 显示文摘 | Schmitt M Fernandes C P da Cunha Neto J A B | 2013 | Marine and Petroleum Geology2013，39，1： | 1 |
| 4 | Mechanical properties of polyester mooring cables 显示文摘 | FERNANDES A C DEL VECCI-IIO C J M CASTRO G A V | 1999 | International Journal of Offshoreand Polar Engineering1999，9，3： | 1 |
| 5 | Effects of herbivory by Hyblaea puera ( Hyblaeidae : Lepidop- tera) on litter production in the mangrove on the coast of Brazi- lian Amazonia显示文摘 | FERNANDES M E B NASCIMENTO A A M CARVALHO M L | 2009 | Journal of Tropical Ecology2009，25，3： | 1 |
| 6 | Effects of muscarinic cholinergic receptor antagonists on postnatal eye growth of rhesus monkeys显示文摘 | Tigges M Iuvone PM Fernandes A | 1999 | Optom Vis Sci1999，76，6： | 1 |
| 7 | Hydrolysis and synthesis reactions catalysed by Thermomyces lanuginosa lipase in the AOT/Isooctane reversed micellar system 显示文摘 | Fernandes M L M Krieger N Baron A M | 2004 | J Mol Catal B : Enzym2004，30，1： | 1 |
| 8 | Production of Coated Papers with Improved Properties by Using a Water-soluble Chitosan Derivative显示文摘 | FERNANDES S C M FREIRE C S R SILVESTRE A J D | 2010 | Ind Eng Chem Res2010，49，14： | 1 |
| 9 | Room temperature PL characterization of micro and nanocrystalline diamond grown by MPCVD from Ar/H2/CH4 mixtures 显示文摘 | NET() M A FERNANDES A J S SILVA R F | 2007 | Vacuum2007，81，： | 1 |
| 10 | Influence of the Sulphurization Time on the Morphological, Chemical, Structural and Electrical Properties of Cu2 ZnSnS4 Polyerystalline Thin Films 显示文摘 | Gonzalez J C Fernandes P A Ribeiro G M | 2014 | Solar Energy Materials and Solar Cells2014，123，： | 1 |
| 11 | Comparative structural analysis of et-glucosidase inhibitors on difference species: a computational study 显示文摘 | Narayana Moorthy N S Ramos M J Fernandes P A | 2012 | Arch Pharm (Weinheim)2012，345，4： | 1 |
| 12 | Structure and Performance of the Service Sector in Transition Economies显示文摘 | FERNANDES A M | | 0，，03： | 1 |
| 13 | Short-term clinical of peel-off facial mask moisturizers显示文摘 | Velasco M V R Vieira R P Fernandes A R | 2014 | International Jour- nal of Cosmetic Science2014，36，： | 1 |
| 14 | Early surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the International Surgical Trial in Intracerebral Haemorrhage (STICH): a randomised trial显示文摘 | A David Mendelow Barbara A Gregson Helen M Fernandes Gordon D Murray Graham M Teasdale D Terence Hope Abbas Karimi M Donald M Shaw David H Barer | 2005 | The Lancet2005，，9457： | 1 |
| 15 | Glycemic index of potatoes commonly consumed in North America显示文摘 | FERNANDES G VELANGI A WOLEVER T M S | 2005 | Journal of the American Dietetic Association2005，105，： | 1 |
| 16 | A Rac homolog functions downstream of Rasl to control hyphal differentiation and high-temperature growth in the pathogenic fungus Cryptococcus neoformans显示文摘 | Vallim M A Nichols C B Fernandes L | 2005 | Eukaryotic Cell2005，4，6： | 1 |
| 17 | Mathematical model coupling phase transformation and temperature evolution during quenching of steels显示文摘 | Fernandes F M B Denis S Simon A | 1984 | Materials Science and Technology1984，1，10： | 1 |
| 18 | Treatment of human monocytes with interleukin(IL)-18 increases TLR4 and mannose receptor expression and modulates cytokine production显示文摘 | Dias-Melicio L A Fernandes R K Golim M A | | 0，，1： | 1 |
| 19 | Flavonoid Metabolites Transport across a Human Bbb Model 显示文摘 | Faria A Meireles M Fernandes 1 | 2014 | Food Chemistry2014，149，： | 1 |
| 20 | Optimisation of the biological treatment of hypersaline wastewater from Dunaliella salina carotenogenesis 显示文摘 | Santos C A Vieira A M Fernandes H L | 2001 | J Chem Technol Biotechnol2001，76，11： | 1 |
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