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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Early surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the International Surgical Trial in Intracerebral Haemorrhage (STICH): a randomised trial显示文摘 | A David Mendelow Barbara A Gregson Helen M Fernandes Gordon D Murray Graham M Teasdale D Terence Hope Abbas Karimi M Donald M Shaw David H Barer | 2005 | 2005 (9457)2005，，9457： | 2 |
| 3 | Prepara- tion and characterization of foams from sheet glass and fly ash using carbonates as foaming agents 显示文摘 | Fernandes H R Tulyaganov D U Ferreira J M F | 2009 | Ceram Int2009，35，1： | 1 |
| 4 | Isolation and characterization of oncorhyncin II,a histone H1-derived antimicrobial peptide from skin secretions of rainbow trout,Oncorhynchus mykiss显示文摘 | FERNANDES J M MOLLE G KEMP G D | 2004 | Developmental and Comparative Immunology2004，28，2： | 1 |
| 5 | Synthesis and characterization of novel chiral ionic liquids and investigation of their enantiomeric recognition properties显示文摘 | Bwambok D K Marwani H M Fernand V E | 2008 | Chirality2008，20，： | 1 |
| 6 | Production of Coated Papers with Improved Properties by Using a Water-soluble Chitosan Derivative显示文摘 | FERNANDES S C M FREIRE C S R SILVESTRE A J D | 2010 | Ind Eng Chem Res2010，49，14： | 1 |
| 7 | Photochemical processes and the environmental impact of petroleum spills 显示文摘 | Nicodem D E Fernandes M C Z Guedes C L B | 1997 | Biogeochemistry1997，39，： | 1 |
| 8 | Isolation and characterization of oncorhync;in H,a his-tone HI-derived antimicrobial peptide from skin secre-tions of rainbow trout,Oncorhynchus mykiss 显示文摘 | FERNANDES J M O MOLLE G KEMP G D | 2004 | De-velopmental and Comparative Immunology2004，28，2： | 1 |
| 9 | Early surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the International Surgical Trial in Intracerebral Haemorrhage (STICH): a randomised trial显示文摘 | A David Mendelow Barbara A Gregson Helen M Fernandes Gordon D Murray Graham M Teasdale D Terence Hope Abbas Karimi M Donald M Shaw David H Barer | 2005 | The Lancet2005，，9457： | 1 |
| 10 | Characterization of the triplet state of tris( 8-hydro xyquinoline)aluminlum(III) in benzene solution显示文摘 | Burrows H D Fernandes M Seixas de Melo J | 2003 | J Am Chem Soc2003，125，15： | 1 |
| 11 | Influence of blending soybean, sunflower, colza, corn, cottonseed, and residual cooking oil methyl biodiesels on the oxidation stability 显示文摘 | Serqueira D S Fernandes D M Cunha R R | 2014 | Fuel2014，118，： | 1 |
| 12 | Brominated organic micropollutants-igniting the flame retardant issue显示文摘 | D'SILVA K FERNANDES A ROSE M | 2004 | Crit Rev Env Sci Technol2004，34，： | 1 |
| 13 | Kinetic study of the thermal decomposition of poly (vinyl alcohol )/ kraft lignin derivative blends 显示文摘 | Fernandes D M Winkler Hechenleitner A A Gomez Pineda E A | 2006 | Thermochimica Acta2006，，441： | 1 |
| 14 | Replacement of fish meal by plant protein sources up to 75% induces good growth performance without affecting flesh quality in ongrowing Senegalese sole 显示文摘 | CABRAL E M FERNANDES T J R CAMPOS S D | 2013 | Aquaculture2013，，： | 1 |
| 15 | Isolation and characterisation of oncorhyncin II , a histone HI- derived antimicrobial peptide from skin secretions of rainbow trout, Oncorhynchus mykiss显示文摘 | Fernandes J M Molle G Kemp G D | 2004 | Developmen- tal and Comparative Immunology2004，28，2： | 1 |
| 16 | Effect of low-level laser therapy on patient reported measures of oral mucositis and quality of life in head and neck cancer patients receiving chemoradiotherapy-a randomized controlled trial 显示文摘 | GAUTAM A P FERNANDES D J VIDYASAGAR M S | 2013 | Support Care Cancer2013，21，5： | 1 |
| 17 | Changes in lipid content and fatty acid composition along the reproductive cycle of the freshwater mussel Dreissena polymorpha: its modulation by clofibrate exposure显示文摘 | Lazzara R Fernandes D Faria M | 2012 | Science of the Total Environment2012，432，： | 1 |
| 18 | Nitrogen and organic load removal from sanitary landfill leaehates by anodie oxidation at Ti/ Pt/PbO2 , Ti/Pt/SnOz-Sb2 04 and Si/BDD 显示文摘 | FERNANDES A SANTOS D PACHECO M J | 2014 | Appl Catal B-Environ2014，，： | 1 |
| 19 | Using gas pipeline pressure to liquefy natural gas or generate electricity 显示文摘 | Shen D M Fernandes F Simoes - moreira J R | 2006 | Gas Processing Developments2006，85，1： | 1 |
| 20 | Replacement of fish meal by plant protein sources up to 75% induces good growth performance without affecting flesh quality in ongrowing Senegalese sole 显示文摘 | Cabral E M Fernandes T J R Campos S D | 2013 | Aquaculture2013，，： | 1 |
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