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| 1 | Redox status and pro-survival/pro-apoptotic protein expression in the early cardiac hypertrophy induced by experimental hyperthyroidism显示文摘 | Fernandes RO Dreher GJ Schenkel PC | | 0，，07： | 1 |
| 2 | Time course of hydrogen peroxide-thioredoxin balance and its influence on the intracellular signalling in myocardial infarction显示文摘 | Schenkel PC Tavares AM Fernandes RO | 2012 | Exp Physiol2012，97，： | 1 |
| 3 | Time course of hy- drogen peroxide-thioredoxin balance and its influence on the intra- cellular signaling in myocardial infarction显示文摘 | Schenkel PC Tavares AM Fernandes RO | 2012 | Exp Physiol2012，97，6： | 1 |
| 4 | Nitrogen-limited mangrove ecosystems conserve N through dissimilatory nitrate reduction to ammonium显示文摘 | Fernandes SO Bonin PC Michotey VD | | 0，，： | 1 |
| 5 | Dimethylchromene rotenoids from Tephrosia candida 显示文摘 | Andrei CC Vieira PC Fernandes JB | 1997 | Phytochemistry1997，46，6： | 1 |
| 6 | Isolation of secoisolariciresinol diesters from stems of simaba cuneata 显示文摘 | Edson RF Fernandes JB Vieira PC | 1992 | Phytochemistry1992，31，： | 1 |
| 7 | Circu- lating neutrophils may play a role in the host response in cervical cancer显示文摘 | Fernandes PC Jr Garcia CB Micheli DC | 2007 | Int J Gynecol Cancer2007，17，5： | 1 |
| 8 | Robotic-assisted pancreatic surgery 显示文摘 | Fernandes E Giulianotti PC | 2013 | J Hepatobiliary Pancreat Sci2013，，： | 1 |
| 9 | A technical approach to the evaluation of glucose oxidation:implications for diabetic cataract显示文摘 | Pereira PC Fernandes R Ramalho JS | 1996 | Ophthalmic Res1996，28，5： | 1 |
| 10 | Static mixers asheat exchangers in supercritical fluid extraction processes显示文摘 | Simoes PC Afonso B Fernandes J | 2008 | J Supercrit Fluids2008，43，47： | 1 |
| 11 | Computational-flu-id-dynamic study of a Kenics static mixer as a heat exchangerfor supercritical carbon dioxide显示文摘 | Lisbos PF Fernandes J Simoes PC | 2010 | J Supercrit Fluids2010，55，： | 1 |
| 12 | Myofibroblastic inflammatory breast tumor and fibrosarcoma:a case report显示文摘 | Nomelini RS Jammal MP Fernandes PC | 2011 | Eur J Gynaecol Oncol2011，32，5： | 1 |
| 13 | Abnormal methylation of imprinted genes in human sperm is associated with oligozoospermia显示文摘 | Marques PC Vaz F Carvalho Fernandes A Barros and M Sousa | 2008 | MHR -Basic Science of Reproductive Medicine2008，14，： | 1 |
| 14 | A technical approach to the evaluation of glucose oxidation, implications for diabetic cataract显示文摘 | Pereira PC Fernandes R Ramalho JS | 1996 | Ophthalmic Res1996，28，： | 1 |
| 15 | A technical approach to the evaluation of glucose oxidation: Implications for diabetic cataract 显示文摘 | Pereira PC Fernandes R Ramalho JS | 1996 | Ophthalmic Res1996，28，5： | 1 |
| 16 | Association of angiotensin-con- verting enzyme activity and polymorphism with echocardiographic meas- ures in familial and nonfamilial hypertrophic cardiomyopathy显示文摘 | Buck PC Fernandes F Arteaga E | 2009 | Braz J Med Biol Res2009，42，8： | 1 |
| 17 | Epilepsy stigma perception in an urban area of a limited-resource country显示文摘 | Fernandes PT Salgado PC Noronha AL | 2007 | Epilepsy Behav2007，11，1： | 1 |
| 18 | Analysis of 12 variants in the development of gastric and colorectal cancers显示文摘AIM To evaluate the relation between 12 polymorphisms and the development of gastric cancer(GC) and colorectal cancer(CRC).METHODS In this study,we included 125 individuals with GC diagnosis,66 individuals with CRC diagnosis and 475 cancer-free individuals. All participants resided in the North region of Brazil and authorized the use of their samples. The 12 polymorphisms(in CASP8,CYP2 E1,CYP19 A1,IL1 A,IL4,MDM2,NFKB1,PAR1,TP53,TYMS,UGT1 A1 and XRCC1 genes) were genotyped in a single PCR for each individual,followed by fragment analysis. To avoid misinterpretation due to population substructure,we applied a previously developed set of 61 ancestryinformative markers that can also be genotyped by multiplex PCR. The statistical analyses were performed in Structure v.2.3.4,R environment and SPSS v.20.RESULTS After statistical analyses with the control of confounding factors,such as genetic ancestry,three markers(rs79071878 in IL4,rs3730485 in MDM2 and rs28362491 in NFKB1) were positively associated with the development of GC. One of these markers(rs28362491) and the marker in the UGT1 A1 gene(rs8175347) were positively associated with the development of CRC. Therefore,we investigated whether the joint presence of the deleterious alleles of each marker could affect the development of cancer and we obtained positive results in all analyses. Carriers of the combination of alleles RP1 + DEL(rs79071878 and rs28361491,respectively) are at 10-times greater risk of developing GC than carriers of other combinations. Similarly,carriers of the combination of DEL + RARE(rs283628 and rs8175347) are at about 12-times greater risk of developing CRC than carriers of other combinations.CONCLUSION These findings are important for the comprehension of gastric and CRC development,particularly in highly admixed populations,such as the Brazilian population. | Giovanna C Cavalcante Marcos AT Amador Andre M Ribeiro dos Santos Darlen C Carvalho Roberta B Andrade Esdras EB Pereira Marianne R Fernandes Danielle F Costa Ney PC Santos Paulo P Assumpcao Andrea Ribeiro dos Santos Sidney Santos | 2017 | World Journal of Gastroenterology2017，23，48： | 0 |
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