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| 1 | 满足新版IEC1000-3-2标准规定(2000版)的单相LC滤波整流器的设计显示文摘本文对用于满足新版IEC10 0 0 3 2 (第二版 )电流谐波限制标准规定的单相全桥LC滤波整流器进行了分析和设计。结果表明 ,如果设计适当的滤波电感值 ,本文所述的无源功率因数校正方法可以满足标准所要求的规定。本文分析了新版IEC10 0 0 3 2标准中划分为A类和D类电力电子产品满足标准规定的条件情况。计算机仿真和实验验证理论分析和计算结果。 | 林维明 Javier Sebastián A Fernandez | 2002 | 电工电能新技术2002，21，2： | 7 |
| 2 | Role of ATG16L,NOD2 and IL23R in Crohn's disease pathogenesis显示文摘Inflammatory bowel disease is a group of diseases that includes Crohn's disease (CD) and ulcerative colitis.CD is characterized as a chronic inflammatory disease of the gastrointestinal tract,ranging from the mouth to the anus.Although there are gross pathological and histological similarities between CD and Johne's disease of cattle,the cause of CD remains controversial.It is vital to understand fully the cause of this disease because it affects approximately 500 000 people in North America and Europe.It ranges from 27 to 48 cases per 100 000 people.There are many theories on the cause of CD ranging from possible association with environmental factors including microorganisms to imbalance in the intestinal normal flora of the patients.Regardless of the environmental trigger,there is strong evidence that a genetic disposition is a major key in acquiring CD.Many studies have proven the link between mutations in the ATG16L,NOD2/CARD15,IBD5,CTLA4,TNFSF15 and IL23R genes,and CD.The purpose of this review is to examine all genetic aspects and theories of CD,including up to date multiple population studies performed worldwide. | Saleh A Naser Melissa Arce Anam Khaja Marlene Fernandez Najih Naser Sammer Elwasila Saisathya Thanigachalam | 2012 | World Journal of Gastroenterology2012，18，5： | 5 |
| 3 | Altered blood-brain barrier permeability in rats with prehepatic portal hypertension turns to normal when portal pressure is lowered显示文摘AIM: To study the blood-brain barrier integrity in prehe-patic portal hypertensive rats induced by partial portal vein ligation, at 14 and 40 d after ligation when portal pressure is spontaneously normalized. METHODS: Adult male Wistar rats were divided into four groups: GroupⅠ: Sham14d, sham operated; GroupⅡ: PH14d, portal vein stenosis; (both groups were used 14 days after surgery); GroupⅢ: Sham40d, Sham operated and GroupⅣ: PH40d Portal vein stenosis (GroupsⅡandⅣused 40 d after surgery). Plasma ammonia, plasma and cerebrospinal fluid protein and liver enzymes concentrations were determined. Trypan and Evans blue dyes, systemically injected, were investigated in hippocampus to study blood-brain barrier integrity. Portal pressure was periodically recorded. RESULTS: Forty days after stricture, portal pressure was normalized, plasma ammonia was moderately high, and both dyes were absent in central nervous system parenchyma. All other parameters were reestablished. When portal pressure was normalized and ammonia level was lowered, but not normal, the altered integrity of blood-brain barrier becomes reestablished. CONCLUSION: The impairment of blood-brain barrier and subsequent normalization could be a mechanism involved in hepatic encephalopathy reversibility, Hemo-dynamic changes and ammonia could trigger blood-brain barrier alterations and its reestablishment. | Francisco Eizayaga Camila Scorticati Juan P Prestifilippo Salvador Romay Maria A Fernandez José L Castro Abraham Lemberg Juan C Perazzo | 2006 | World Journal of Gastroenterology2006，12，9： | 3 |
| 4 | Histological and molecular classification of gliomas显示文摘Rev Neurol (Paris). 2008 June-July;164(6-7):505-515. Epub 2008 Jun 10.Gliomas are the most frequent tumors of the central nervous system. The WHO classification, based on the presumed cell origin,distinguishes astrocytic,oligodendrocytic and mixed gliomas. A grading system is based on the presence of the following criteria: in- | Figarella-Branger D Colin C Coulibaly B Quilichini B Maues De Paula A Fernandez C Bouvier C | 2008 | 中国神经肿瘤杂志2008，6，2： | 3 |
| 5 | Impaired CTLA-4 responses in COPD are associated with systemic inflammation显示文摘 | Dino BA Tan Sonia Fernandez PatriciaPrice Martyn A French Philip J Thompson Yuben P Moodley | 2014 | Cellular & Molecular Immunology2014，11，6： | 3 |
| 6 | Electrodeposited and selenized (CuInSe2) (CIS) thin films for photovoltaic applications显示文摘 | Fernandez A M Calixto M E Sebastian P J | 1998 | Solar Energy Materials &Solar Cells1998，52，34： | 2 |
| 7 | Epidemiological link between obesity,type 2 diabetes mellitus and cancer显示文摘There exists a complex interaction between obesity,type 2 diabetes mellitus(T2DM)and cancer,and an increase in the incidence of cancer is expected with the growing obesity-diabetes pandemic.The association of cancer with diabetes mellitus and obesity appears to be site-specific,the highest risk being for postmenopausal breast cancer,endometrial cancer,and colorectal cancer.Moreover,there is worsening of hyperglycaemia with the onset of cancer,evidencing a bidirectional link between cancer and diabetes mellitus and the need for monitoring for diabetes in cancer survivors.In this review,we look at the epidemiological evidence from observational studies and Mendelian randomization studies linking obesity,diabetes,and cancer,as well as the complex pathophysiological mechanisms involved,including insulin resistance with associated hyperinsulinaemia,the effect of chronic low-grade inflammation,and the effect of various adipokines that are associated with obesity and T2DM.Additionally,we describe the novel therapeutic strategies,based on their role on the discrete pathophysiological mechanisms involved in the tumourigenesis. | Cornelius J Fernandez Annu Susan George Nikhila A Subrahmanyan Joseph M Pappachan | 2021 | World Journal of Methodology2021，11，3： | 2 |
| 8 | Occurrence of Organochlorine Insecticides, PCBs and PCB Congeners in waters and Sediments of the Ebro River (Spain) 显示文摘 | Fernandez M A Alonso C Gonzalez M J | 1999 | Chemosphere1999，38，： | 2 |
| 9 | Cadmium inhibition of a structural wheat peroxidase显示文摘 | Converso D A Fernandez M E Tomaro M L | 2000 | J Enzy Inhib2000，15，： | 2 |
| 10 | Non-alcoholic fatty liver disease in patients with intestinal, pulmonary or skin diseases: Inflammatory cross-talk that needs a multidisciplinary approach显示文摘Non-alcoholic fatty liver disease(NAFLD)is currently considered the most common cause of liver disease.Its prevalence is increasing in parallel with the obesity and type 2 diabetes mellitus(DM2)epidemics in developed countries.Several recent studies have suggested that NAFLD may be the hepatic manifestation of a systemic inflammatory metabolic disease that also affects other organs,such as intestine,lungs,skin and vascular endothelium.It appears that local and systemic proinflammatory/anti-inflammatory cytokine imbalance,together with insulin resistance and changes in the intestinal microbiota,are pathogenic mechanisms shared by NAFLD and other comorbidities.NAFLD is more common in patients with extrahepatic diseases such as inflammatory bowel disease(IBD),obstructive syndrome apnea(OSA)and psoriasis than in the general population.Furthermore,there is evidence that this association has a negative impact on the severity of liver lesions.Specific risk characteristics for NAFLD have been identified in populations with IBD(i.e.age,obesity,DM2,previous bowel surgery,IBD evolution time,methotrexate treatment),OSA(i.e.obesity,DM2,OSA severity,increased transaminases)and psoriasis(i.e.age,metabolic factors,severe psoriasis,arthropathy,elevated transaminases,methotrexate treatment).These specific phenotypes might be used by gastroenterologists,pneumologists and dermatologists to create screening algorithms for NAFLD.Such algorithms should include non-invasive markers of fibrosis used in NAFLD to select subjects for referral to the hepatologist.Prospective,controlled studies in NAFLD patients with extrahepatic comorbidities are required to demonstrate a causal relationship and also that appropriate multidisciplinary management improves these patients’prognosis and survival. | Mercedes Perez-Carreras Begoña Casis-Herce Raquel Rivera Inmaculada Fernandez Pilar Martinez-Montiel Victoria Villena | 2021 | World Journal of Gastroenterology2021，27，41： | 2 |
| 11 | Developing a Marker of exposure to xenoestrogen mixtures in human serum显示文摘 | Soto A M Fernandez M F Luizzi M F | 1997 | Environ Health Perspect1997，105，3： | 2 |
| 12 | The Gentleman's code of Confucius: Leadership by values 显示文摘 | FERNANDEZ J A | 2004 | Organizational Dynamics2004，33，1： | 1 |
| 13 | Determinants of innovation through a knowledge -based theory lens显示文摘 | Aranda D A Molina- Fernandez L M | 2002 | Industrial Management Data Systems2002，102，56： | 1 |
| 14 | Dendritic cells directly trigger NK cell functions:cross-talk relevant in innate anti-tumor immune responses in vivo显示文摘 | Fernandez NC Lozier A Flament C | 1999 | Nat Med1999，5，4： | 1 |
| 15 | Chiral bis(amino alcohol)oxalamides as ligands for asymmetric catalysis,Ti(Ⅳ)catalyzed enantioselective addition of diethylzinc to aldehydes显示文摘 | BLAY G FERNANDEZ I MARCO-ALEIXANDRE A | 2005 | Tetrahedron:Asymmetry2005，16，6： | 1 |
| 16 | Journal of Chromatography A显示文摘 | Carro A M Lorenzo R A Fernandez F Rodil R Cela R | 2005 | 1071: 932005，1071，： | 1 |
| 17 | A conserved mutation in an ethylene biosynthesis enzyme leads to andromonoecy in melons显示文摘 | Boualem A Fergany M Fernandez R | 2008 | Science2008，321，5890： | 1 |
| 18 | Struc-ture of the FoxMl DNA-recognition domain bound to a pro-moter sequence显示文摘 | Little D R Alvarez Fernandez M Stein A | 2010 | Nucl Acids Res2010，38，13： | 1 |
| 19 | Materials used as PCM in thermal energy storage in buildings: a review 显示文摘 | Cabeza E Castell A Barreneche C Graeia A Fernandez A | 2011 | Renewable and Sustainable Energy Reviews2011，15，3： | 1 |
| 20 | Oral contra-ceptives and colorectal cancer risk:a meta-analysis显示文摘 | Fernandez E La Vecchia C Balducci A | 2001 | Br J Cancer2001，84，5： | 1 |
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