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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Induction of thiohrans-ferase and thioredoxin/thioredoxin reductase systems in cultured porcine lenses under oxidative stress显示文摘 | MOON S FERNANDO M R LOU M F | 2005 | Invest Ophthalmol Vis Sci2005，46，10： | 1 |
| 3 | Sex-stratifiedsocio-economie gradients in physical inactivity, obesity, and dia- betes:Evidence of short-term changes in Argentina 显示文摘 | BRUNO L FERNANDO D M DANIEL F | 2013 | lnt J Public Health2013，58，2： | 1 |
| 4 | Consequence a- nalysis by means of characteristic curves to determine the damage to humans from the detonation of explosive substances as a function of TNT equivalence显示文摘 | Fernando D A Enrique G F Marta D M | 2008 | Journal of Loss Prevention in the Process Industries2008，20，1： | 1 |
| 5 | Cuff-leak test for the diagnosis of upper airway obstruction in adults : a systematic review and meta-analysis 显示文摘 | Mafia E O Maria C M Fernando F V | 2009 | Intensive Care Med2009，35，7： | 1 |
| 6 | A note on the dissipation due to generaized diffusion with electro - chemo- mechanical couplings in heteroionec clays 显示文摘 | Simoes L B Gajo A Fernando M F | 2004 | European Journal of Mechanics A/Solids2004，23，： | 1 |
| 7 | Stress-strain relationship in axial compression for concrete using recycledsaturated coarse aggregate显示文摘 | BELEN G F FERNANDO M A DIEGO C L | 2011 | Construction and Building materials2011，25，5： | 1 |
| 8 | Multi-UAV cooperative perception teehniques显示文摘 | Luis M Fernando C Joaquin F | 2007 | Springer Tracts in Advanced Robot- ics2007，37，1： | 1 |
| 9 | Evaluation of HIS,PCA and Wavelet Transform fusion techniques for the indentification of landslide scars using satellite data显示文摘 | Emerson V M Leila M G F Fernando V | 2003 | Anais XI SBSR Belo Horizonte Brasil 05-01 aBril INPE2003，，： | 1 |
| 10 | Effect of high fiber products on blood lipids and lipoproteins in hamsters 显示文摘 | Hector E M F Yoon K C Fernando M B | 2004 | Nutrition Research2004，24，： | 1 |
| 11 | Matrix effects observed dur- ing pesticides residue analysis in fruits by GC显示文摘 | SILVIA S F FERNANDO M L | 2009 | J Sep Sci2009，32，21： | 1 |
| 12 | ' Alperujo' compost amendment of contaminated calcareous and acidic soils: Effects on growth and trace element uptake by five Brossica species显示文摘 | Fernando F Rosana G-de-la-F Rosa M B | 2009 | Bioresource Technology2009，100，： | 1 |
| 13 | Effect of copper and zinc on the activated sludge bacteria growth kinetics显示文摘 | Alberto C Sara F Fernando M | 1998 | Wat Res1998，32，： | 1 |
| 14 | Conversion of glycerol to hydrogen via asteam reforming process over nickel catalysts显示文摘 | ADHIKARI S FERNANDO S D TO S D F BRICKA R M STEELE P H HARYANTO A | 2008 | Energy Fuels2008，22，2： | 1 |
| 15 | Kinetic evaluation and modeling of lignin catalytic wet oxidation to selective production of aromatic aldehydes显示文摘 | Fernando G Laisse C A M Nelson M L F | 2006 | American Chemical Society2006，45，20： | 1 |
| 16 | Mapping the domain of troponin T responsible for the activation of actomyosin ATPase activity显示文摘 | Clóvis R N Aurea D S Chuck S F Fernando C R | | J Biol Chem0，275，27： | 1 |
| 17 | prevalence, con - sequences and effeetive treatment显示文摘 | Cunnington D Junge M F Fernando A T | 2013 | Med J Aust2013，199，8： | 1 |
| 18 | Temporary self-expandable metal stent placement for treatment of post-sphincterotomy bleeding显示文摘 | Janak NS Fernando M Kenneth F | 2010 | Gastrointest Endosc2010，72，6： | 1 |
| 19 | Text categorization methods for automatic estimation of verbal intelligence显示文摘 | Fernando F Kseniya Z Wolf-Gang M | 2012 | Expert Systems with Applications2012，39，10： | 1 |
| 20 | Kinetic evaluation and modeling of lignin catalytic wet oxidation to selective production of aromatic aldehydes显示文摘 | Fernando G Laisse C A M Nelson M L F | 2006 | American Chemical Society2006，45，20： | 1 |
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