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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Analysis of two polymorphisms in the promoter region of matrix metalloproteinase 1 and 3 genes in women with endometriosis显示文摘 | Ferrari MM Biondi ML Rossi G | 2006 | Acta Obstet Gynecol Scand2006，85，2： | 1 |
| 3 | Diabetic foot:from diagnosis to therapy显示文摘 | Zucchi P Ferrari P Spina ML | | 0，，31： | 1 |
| 4 | Diabetic foot: from diagno- sis to therapy显示文摘 | Zueehi P Ferrari P Spina ML | 2005 | GItal Nefrol2005，22，31： | 1 |
| 5 | Osteoporosis in young adults : pathophysiology, diagnosis, and management 显示文摘 | Ferrari S Bianchi ML Eisman JA | 2012 | Osteoporos Int2012，23，： | 1 |
| 6 | Diabetic foot:from diagnosis to therapy 显示文摘 | Zucchi P Ferrari P Spina ML | 2005 | G Ital Nefrol2005，，： | 1 |
| 7 | Analysis of two polymorphisms in the promoter region of matrix metalloproteinase 1 and 3 genes in women with endometriosis显示文摘 | Ferrari MM Biondi ML Rossi G | 2006 | Acta Obstet Gynecol Scand2006，85，2： | 1 |
| 8 | Skin damage and mitochondrial dysfunction after acute ultraviolet B irradiation:relationship with nitric oxide production显示文摘 | Maglio DH Paz ML Ferrari A | 2005 | Photodermatol Photoimmunol Photomed2005，21，6： | 1 |
| 9 | Osteoporosis in young adults : pathophysiology, diagnosis, and management 显示文摘 | Ferrari S Bianchi ML Eisman JA | 2012 | Osteoporos Int2012，23，12： | 1 |
| 10 | Dibetie foot: From diagnosis to therapy 显示文摘 | Zueehi P Ferrari P Spina ML | 2005 | G Ital Nefrol2005，22，31： | 1 |
| 11 | Diabetic foot:from diagnosis to therapy显示文摘 | Zucchi P Ferrari P Spina ML | 2005 | G Ital Nefrol2005，22，31： | 1 |
| 12 | Immune-correlates analysis of an HIV-1 vaccine efficacy trial 显示文摘 | Haynes BF Gilbert PB McElrath MJ Zolla-Pazner S Tomaras GD Alam SM Evans DT Montefiori DC Kar- nasuta C Sutthent R Liao HX DeVico AL Lewis GK Williams C Pinter A Fong Y Janes H DeCamp A Huang Y Rao M Billings E Karasavvas N Robb ML Ngauy V de Souza MS Paris R Ferrari G Bailer RT Soderberg KA Andrews C Berman PW Frahm N De Ro- sa SC Alpert MD Yates NL Shen X Koup RA Pitisut- tithum P Kaewkungwal J Nitayaphan S Rerks-Ngarm S Michael NL Kim JH | 2012 | N Engl J Med2012，366，14： | 1 |
| 13 | Diabetic foot:from diagnosis to therapy显示文摘 | Zucchi P Ferrari P Spina ML | 2005 | G Ital Nefrol2005，22，： | 1 |
| 14 | Efficacy of oxamni- quine and praziquantel in the treatment of Schistosoma mansoni infection: a controlled trial 显示文摘 | Ferrari ML Coelho PM Antunes CM | 2003 | Bull World Health Organ2003，81，3： | 1 |
| 15 | Analysis of two polymorphisms in the promoter region of matrix metalloproteinase 1 and 3 genes in women with endometriosis显示文摘 | Ferrari MM Biondi ML Rossi G | 2006 | Acta Obstet Gynecol Scand2006，85，： | 1 |
| 16 | Diabetic foot: from diagnosis to therapy显示文摘 | ZUCCHI P FERRARI P SPINA ML | 2005 | G Ital Nefrol2005，，： | 1 |
| 17 | Diabetic foot: from diagnosis to therapy显示文摘 | Zucehi P Ferrari P spina ML | 2005 | G Ital Nefrol2005，22，31： | 1 |
| 18 | Diabetic foot: from diagnosis to ther- apy 显示文摘 | Zucchi P Ferrari P Spina ML | 2005 | Gltal Nefro12005，22，31： | 1 |
| 19 | Diabetic foot:from diagnosis to therapy显示文摘 | Zucchi P Ferrari P Spina ML | 2005 | G Ital Nefrol2005，，： | 1 |
| 20 | Diabetic foot: from diagnosis to therapy显示文摘 | Zucchi P Ferrari P Spina ML | 2005 | G Ital Nefrol2005，2231，： | 1 |
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