|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Ammoniavariations in phyto-treatment ponds of land-based fish farmwastewater显示文摘 | PORRELL O FERRARI G LENZI M | 2003 | Aquaculture2003，219，： | 1 |
| 3 | An 'alternative plate tec- tonic model for the Palaeozoic-Early Mesozoic Palaeotethyan evolution of Southeast Asia (Northern Thailand-Bumla) 显示文摘 | Ferrari O M Hochard C Stampfli G M | 2008 | Tectonophysies2008，451，： | 1 |
| 4 | Serum concentration of NSE and S-100b during LVAD in nonresuscitated patients显示文摘 | Pfeifer R Ferrari M B(o)rner A | | 0，，01： | 1 |
| 5 | Oxidation protectiw' rnultitayer coatings for carbon-carbon composites 显示文摘 | SMEACETI'O F SALVO M FERRARIS M | 2002 | Carbon2002，40，4： | 1 |
| 6 | Unanswered questions for management of acute coronary syndrome: risk stratification of patients with minimal disease or normal findings on coronary angiography显示文摘 | Bugiardini R Manfrini O De Ferrari G M | 2006 | Arch Intern Med2006，166，13： | 1 |
| 7 | Analytical methods for the characterization of cationic lipid-nucleic acid complexes 显示文摘 | Ferrari M E Nguyen C M Zelphati O | 1998 | Hum Gene Ther1998，9，： | 1 |
| 8 | Preparatioir of Silver Nanoparticles in Silica Films by Combined Thermal and Electron-beam Doposition显示文摘 | Ferrari M Toset L O C Montagna M | 1995 | J Non-Cryst Solids1995，191，： | 1 |
| 9 | The structure of dentine in the apical region of human teeth显示文摘 | Mj(o)r IA Smith MR Ferrari M | 2001 | Int Endod J2001，34，5： | 1 |
| 10 | Stable and monodisperse lipoplex formulations for gene delivery显示文摘 | Zelphati O Nguyen C Ferrari M | 1998 | G ene Ther1998，5，9： | 1 |
| 11 | Food treatment with high pressure carbon dioxide:Saccharomyces cerevisiae inactivation kinetics expressed as a function of CO2 solubility显示文摘 | Ferrentino G Balaban M O Ferrari G | | 0，，01： | 1 |
| 12 | Apoptosis signaling by death receptor 显示文摘 | Schulze O Shioff K Ferrari D Los M | 1998 | Eur J Biochem1998，254，4： | 1 |
| 13 | Stable and monodisperse lipoplex formulations for gene delivery 显示文摘 | Nguyen C Ferrari M | 1998 | Gene Ther1998，5，： | 1 |
| 14 | An altemative plate tectonic model for the Palaeozoic-Early Mesozoic Palaeotethyan evolution of Southeast Asia ( Northern Thailand-Burma ) 显示文摘 | Ferrari O M Hochard C Stampfli G M | 2008 | Tectonophysics2008，451，： | 1 |
| 15 | Ammonia variations in phyto-treatment ponds of land-based fish farm wastewater 显示文摘 | PORRELL O FERRARI G LENZI M | 2003 | Aquaculture2003，219，： | 1 |
| 16 | Apoptosis signaling by deatn factots显示文摘 | Schulze O K Ferrari D Los M | 1998 | Eur J Biochem1998，254，3： | 1 |
| 17 | Stable and monodisperse Lipoplex formulations for gene delivery显示文摘 | ZELPHATI O NGUYEN C FERRARI M | 1998 | Gene Ther1998，5，9： | 1 |
| 18 | Stable and monodisperse lipoplex formulatins for gene delivery显示文摘 | Zelphati O Nguyen C Ferrari M | 1998 | Gene Ther1998，5，： | 1 |
| 19 | Effects of ocean acidification on visual risk assessment in coral reef fishes 显示文摘 | Ferrari M C O McCormick M I Munday P L | 2012 | Functional Ecology2012，26，3： | 1 |
| 20 | Chemical e- cology of predator-prey interactions in aquatic ecosys- tems: A review and prospectus 显示文摘 | Ferrari M C O Wisenden B D Chivers D P | 2010 | Canadian Journal of Zoology2010，88，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员