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| 1 | Circulating leptin and its muscle gene expression in Nellore cattle with divergent feed efficiency显示文摘Background: Leptin has a strong relation to important traits in animal production, such as carcass composition,feed intake, and reproduction. It is mainly produced by adipose cells and acts predominantly in the hypothalamus.In this study, circulating leptin and its gene expression in muscle were evaluated in two groups of young Nellore bulls with divergent feed efficiency. Individual dry matter intake(DMI) and average daily gain(ADG) of 98 Nellore bulls were evaluated in feedlot for 70 d to determinate the residual feed intake(RFI) and select 20 animals for the high feed efficient(LRFI) and 20 for the low feed efficient(HRFI) groups. Blood samples were collected on d 56 and at slaughter(80 d) to determine circulating plasma leptin. Samples of Longissimus dorsi were taken at slaughter for leptin gene expression levels.Results: DMI and RFI were different between groups and LRFI animals showed less back fat and rump fat thickness,as well as less pelvic and kidney fat weight. Circulating leptin increased over time in all animals. Plasma leptin was greater in LRFI on 56 d and at slaughter(P = 0.0049). Gene expression of leptin were greater in LRFI animals(P = 0.0022) in accordance with the plasma levels. The animals of the LRFI group were leaner, ate less, and had more circulating leptin and its gene expression.Conclusion: These findings demonstrated that leptin plays its physiological role in young Nellore bulls, probably controlling food intake because feed efficient animals have more leptin and lower residual feed intake. | Lúcio Flávio Macedo Mota Cristina Moreira Bonafé Pamela Almeida Alexandre Miguel Henrique Santana Francisco JoséNovais Erika Toriyama Aldrin Vieira Pires Saulo da Luz Silva Paulo Roberto Leme JoséBento Sterman Ferraz Heidge Fukumasu | 2018 | Journal of Animal Science and Biotechnology2018，9，1： | 3 |
| 2 | Central nervous system vasculitis and polyneuropathy as first manifestations of hepatitis C显示文摘Sensory or motor peripheral neuropathy may be observed in a significant proportion of hepatitis C virus (HCV)-infected patients.However,central nervous system (CNS) involvement is uncommon,especially in cryoglobulin-negative subjects.We describe a case of peripheral neuropathy combined with an ischemic CNS event as primary manifestations of chronic HCV infection without cryoglobulinemia.Significant improvement was observed after antiviral therapy.We discuss the spectrum of neurological manifestations of HCV infection and review the literature. | Roberto J Carvalho-Filho Janaína Luz Narciso-Schiavon Luciano HL Tolentino Leonardo L Schiavon Maria Lucia G Ferraz Antonio Eduardo B Silva | 2012 | World Journal of Gastroenterology2012，18，2： | 3 |
| 3 | Association between the CYBA and NOX4 genes of NADPH oxidase and its relationship with metabolic syndrome in non-alcoholic fatty liver disease in Brazilian population显示文摘Background: Oxidative stress has been implicated in the progression of severe forms of non-alcoholic fatty liver disease(NAFLD). NADPH oxidase produces reactive oxygen species. In the present study, we investigated for the first time two single nucleotide polymorphisms(SNPs) in the regulatory region of genes encoding NADPH oxidase 4(NOX4) and p22 phox(CYBA) in NAFLD.Methods: A total of 207 biopsy-proven NAFLD patients [simple steatosis(n = 27); nonalcoholic steatohepatitis(NASH)(n = 180)] were evaluated. Genomic DNA was extracted from peripheral blood cells, and polymorphisms in CYBA(unregistered) and NOX4(rs3017887) were determined by direct sequencing of PCR.Results: Associations of CYBA-675 T/A with high-density lipoprotein(HDL)(TT vs TA vs AA; P < 0.01) and triglycerides(TGL)(TT vs XA; P < 0.01) were observed only in NASH patients. For polymorphisms in the NOX4 gene, NOX4(rs3017887) CA + AA genotypes was significant associated with alanine aminotransferase(ALT)(CA + AA vs CC; P = 0.02). However, there was no association of SNPs in the CYBA and NOX4 genes encoding the NADPH oxidase system proteins and the presence of NASH. Regarding the clinical results, it was observed that the most advanced degrees of fibrosis occurred in patients diagnosed with type 2 diabetes mellitus(66.9% vs 37.5%, P < 0.01) and those who were more obese(32.2 vs 29.0 kg/m2,P < 0.01). In addition, serum glucose and insulin levels increased significantly in the presence of NASH.Conclusions: There were associations between the presence of the allele A in the NOX4 SNP and a higher concentration of ALT in the NAFLD population; between the presence of the AA genotype in the polymorphism of the CYBA-675 T/A CYBA gene and a higher level of TGL and lower HDL in NASH patients. The presence of metabolic syndrome was associated with advanced degrees of fibrosis in NAFLD patients. | Fabiola Rabelo Jose Tadeu Stefano Ana Mercedes Cavaleiro Rodrigo Vieira Costa Lima Daniel Ferraz de Campos Mazo Flair Jose Carrilho Maria Lúcia Correa-Giannellac Claudia P.Oliveiraa | 2018 | Hepatobiliary & Pancreatic Diseases International2018，17，4： | 2 |
| 4 | Hydrogen sul- fide : an endogenous mediator of resolution of inflamma- tion and injury 显示文摘 | Wallace J L Ferraz J G Muscara M N | 2012 | Antioxid Redox Signal2012，17，1： | 1 |
| 5 | Xanthine Oxidase Inhibitory Activity of Lychnophora Species From Brazil (' Arnica') 显示文摘 | FERRAZ FILLHA Z S VITOLO I F FIETTO L G | 2006 | Journal of Ethno- pharmacology2006，，107： | 1 |
| 6 | Clinical consequences of un-treated dental caries and toothache in preschool children显示文摘 | Ferraz NK Nogueira LC Pinheiro M L | 2014 | Pediatr Dent2014，36，5： | 1 |
| 7 | Relia bility of pain scales in the assessment of literate and illi terate patients with rheumatoid arthritis显示文摘 | Ferraz M B Quaresma M R Aquino L R | 1990 | J Rheuma tol1990，17，8： | 1 |
| 8 | Ricinine -elicited Seizures A Novel Chemical Model of Convulsive Seizures 显示文摘 | Ferraz A C Pereira L F | 2000 | Pharmaeol Bioebem Behav2000，65，57： | 1 |
| 9 | Identification and characterization of polymorphisms within the 5'flanking region,first exon and part of first intron of bovine GH gene显示文摘 | Ferraz A L Bortolossi J C Curi R A | 2006 | J Anim Breed Genet2006，123，3： | 1 |
| 10 | Follow-upof users of intrauterine device with and without bacterialvaainosis and other cervicovaginal infections显示文摘 | Ferraz do Lago R Simoes JA Bahamondes L | 2003 | Contraception2003，68，2： | 1 |
| 11 | Ferric iron uptake genes are differentially expressed in the presence of copper sulfides in Acidithiobacillus ferrooxidans strain LR显示文摘 | FERRAZ L F C VERDE L C L VICENTINI R | 2011 | Antonie van Leeuwenhoek2011，99，3： | 1 |
| 12 | McCune-Albright syndrome and acromegaly:hormonal control with use of cabergoline and long-acting somatostatin--case report显示文摘 | Almeida J P Albuquerque L A Ferraz C L | 2009 | Arq Bras Endocrinol Metabol2009，53，1： | 1 |
| 13 | Laboratory animals and respiratory allergies: The prevalence of allergies among laboratory animal workers and the need for prophylaxis显示文摘 | Ferraz E Arruda L K D P Bagatin E | 2013 | Clinics2013，68，6： | 1 |
| 14 | Characterization of hemieeUulases and cellulases produced by Ceriporiopsis subvermispora grown on wood under biopulping conditions显示文摘 | Heidorne F O Magalhāes P O Ferraz A L | 2006 | Enzyme Microb Technol2006，38，： | 1 |
| 15 | Hostility and childhood sexual abuse as predictors of suicidal behaviour in borderline personality disorder显示文摘 | Ferraz L Portella M J Vallez M | 2013 | Psychiatry Res2013，210，3： | 1 |
| 16 | Coupling ofan electrodialysis unit to a hollow fiber bioreactor for separationof gluconic acid from sorbitol produced by Zymomonas mobilispermeabilized cells显示文摘 | FERRAZ H C ALVES L M BORGES C P | 2001 | Membrane Sci2001，，191： | 1 |
| 17 | Unexpected distribution of hepatitis C virus genotypes in patients on hemodialysis and kidney transplant recipients 显示文摘 | Perez R M Ferraz M L Figueiredo M S | 2003 | J Mde Virol2003，69，： | 1 |
| 18 | Difference between protein and surfactant foam:microscopic properties,stability and coarsening显示文摘 | Saint J A Peugeot M L Ferraz H | 2005 | Colloids and Surfaces A:Physico Chem Eng Aspects2005，263，13： | 1 |
| 19 | Up-regulation of Annexin-A1 and lipoxin A(4)in individuals with ulcerative colitis may promote mucosal homeostasis显示文摘 | Vong L Ferraz JG Dufton N | 2012 | PLo S One2012，7，39： | 1 |
| 20 | Lack of Evidence of Upper Gastrointestinal Endoscopy as a Risk Factor for Transmission of Hepatitis B Virus 「letter」显示文摘 | Ferrari A P Geocze S Ferraz M L G | 1991 | Endoscopy1991，23，： | 1 |
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