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| 1 | New multi protein patterns differentiate liver fibrosis stages and hepatocellular carcinoma in chronic hepatitis C serum samples显示文摘瞄准:识别一多象用为肝纤维变性(F1-F2 ) 的察觉和区别的提高表面的激光 desorption/ionisation time-of-flight 团 spectrometry (SELDI-TOF-MS ) 的单个蛋白质标记一样的浆液蛋白质模式,在有长期的丙肝病毒(HCV ) 的病人的肝肝硬化(F4 ) andhepatocellular 癌(HCC ) 。方法:有 F1/F2 纤维变性的 39 个病人,的 Serumsamples 有 F4 纤维变性的 44 个病人,有我们重新申请到 CM10 数组并且分析了使用 SELDI-TOF ProteinChip 系统的 HCC 的 34 个病人(PBS-IIc;CiphergenBiosystems ) 在阴离子交换分别以后。所有病人 andhistologically 有长期的丙肝证实的纤维变性 stage/HCC。数据被 multivariatestatistical 技术和人工的神经网络为蛋白质模式分析。结果:4 肽 / 蛋白质 multimarkerpanel (7486, 12843, 44293 和 53598 Da ) 正确地在训练样品(AUROC0.943 ) 的 HCV 肝硬化对 HCV-HCC 的二方法比较与 100% 的敏感和 85% 的特性识别了 HCC。为 HCC 的鉴定的敏感和特性为随机的测试样品是 68% 和 80% 。肝脏硬化症的病人能被歧视有多使用 5peptide/protein 的 F1 或 F2 纤维变性的病人标记模式( 2873 , 6646 , 7775 , 10525 和 67867 Da )与100%和在训练样品( AUROC 0.976 )的85%的敏感和敏感和特性of80%的特性并且67%为随机的测试样品。有 APRI 分数 andalfa-fetopotein (法新社) 的简历标记分类器的联合改进了诊断表演。为肝纤维变性的 6646 Da 标记蛋白质作为 apolipoprotein C-I 被识别。结论:与蛋白质模式分析相结合的 SELDI-TOF-MS 技术与长期的丙肝在病人为肝肝硬化 andhepatocellular 癌的鉴定似乎是一条珍贵途径。最可能,不同浆液标记的联合将帮助以后识别肝肝硬化和早阶段的 hepatocellularcarcinomas。 | Thomas Gbel Sonja Vorderwülbecke Katarzyna Hauck Holger Fey Dieter Hussinger Andreas Erhardt | 2006 | World Journal of Gastroenterology2006,12,47: | 21 |
| 2 | Autophagy is required for self-renewal and differentiation of adult human stem cells显示文摘 | Souzan Salemi Shida Yousefi Mihai A Constantinescu Martin F Fey Hans-Uwe Simon | 2012 | Cell Research2012,22,2: | 17 |
| 3 | The Role of Phosphorylation in Redox Regulation of Photosynthesis Genes psaA and psbA during Photosynthetic Acclimation of Mustard显示文摘对轻质量的坡度的长期的反应(LTR ) 在稠密的看台改进植物的性能和幸存。它包含编码 plastome 的基因 psaAB 的控制氧化还原作用的 transcriptional 规定(编码 photosystem 的 P700 apoproteins 我) 并且 psbA (编码 photosystem II 的 D1 蛋白质) 并且要求质体局部性的 kinases 的行动。为了学习潜力,在 LTR 期间 phosphorylation 事件影响质体基因表示,我们分析了芥末幼苗 acclimated 点亮赞成任何一个 photosystem 的来源我或 photosystem II。psaA 抄本的教材延期分析显示氧化还原作用规定发生在主要细菌的倡导者,建议质体编码了 RNA 聚合酶(锐气) 是为氧化还原作用信号的目标。包含锐气和另外的 DNA 有约束力的蛋白质的叶绿体蛋白质部分经由 heparin-Sepharose 层析从芥末被净化。这些部分的生物化学的性质在倡导者识别和特性上与特殊强调被分析, phosphorylation 状态,和 kinase 活动。结果证明 LTR 包含小 DNA 有约束力的蛋白质的行动;他们中的三个处于 phosphorylation 状态展出特定的变化。另外, Auto-phosphorylation 试金在内长的 kinase 活动的活动展出大差别。有 kinase 禁止者 H7 和 reductant DTT 的叶绿体连续接排的印刷物抄写实验显示 phosphorylation 事件为向 psaA 和 psbA 抄写开始的氧化还原作用信号的调停是必要的,但是要求一个 thiol 氧化还原作用信号的 synergistic 行动。数据支持那个氧化还原作用从 thylakoid 膜表明的想法经由 phosphorylation 事件被连接到基因表示;然而,这调停看起来要求交往的蛋白质而非简单 phosphorelay 的一个复杂网络。 | Sebastian Steiner Lars Dietzel Yvonne Schroter Vidal Fey Raik Wagner Thomas Pfannschmidt | 2009 | Molecular Plant2009,2,3: | 5 |
| 4 | Environmental factors in inflammatory bowel disease: A case-control study based on a Danish inception cohort显示文摘 | Tanja Stenbaek Hansen Tine Jess Ida Vind Margarita Elkjaer Malene Fey Nielsen Michael Gamborg Pia Munkholm | 2011 | Journal of Crohn’s and Colitis2011,,6: | 3 |
| 5 | Kinetic characterization of the electrochemical intercalation of lithium ions into graphite elec- trodes显示文摘 | CHANG Y C JONG J H FEY G T K | 2000 | J Electrochem Soc2000,147,6: | 1 |
| 6 | MNC knowledge transfer, subsidiary absorptive capacity and HRM 显示文摘 | Minbaeva D Pedersen T Bjo'rkman I Fey C Park H J | 2003 | Journal of International Business Studies2003,34,6: | 1 |
| 7 | Effect of temperature on carbon and electron flow and on the archaeal community in methanogenic rice field soil显示文摘 | Fey A Conrad R | | 0,,: | 1 |
| 8 | 查看详情显示文摘 | Zampieri A Kullmann S Selvam T Bauer J Schwieger W Sieber H Fey T Greil P | | 0,,: | 1 |
| 9 | Complementarity of Blue Dye and Isotope in Sentinel Node Localization for Breast Cancer: Univariate and Multivariate Analysis of 966 Procedures显示文摘 | Hiram S. Cody MD Jane Fey MPH Tim Akhurst MD Melissa Fazzari PhD Madhu Mazumdar PhD Henry Yeung MD Samuel D. J. Yeh MD Patrick I. Borgen MD | 2001 | Annals of Surgical Oncology2001,,1: | 1 |
| 10 | Top management incentive compensation and knowledge sharing in multinational corporations 显示文摘 | FEY C F FURU P | 2008 | Strategic Management Journal2008,29,12: | 1 |
| 11 | A trend analysis of the relative value of blue dye and isotope localization in 2,000 consecutive cases of sentinel node biopsy for breast cancer 显示文摘 | Derossis AM Fey J Yeung H | 2001 | J Am Coll Surg2001,193,5: | 1 |
| 12 | Establishment of a real-time PCR-based approach for accurate quantification of bacterial RNA targets in water,using Salmonella as a model organism显示文摘 | Fey A Eichler S Flavier S | 2004 | App Environ Microbiol2004,70,6: | 1 |
| 13 | Modulation of hepatic acute phase gene expression by epidermal growth factor and Src protein tyrosine kinases in murine and human hepatic cells显示文摘 | Wang Y Ripperger J Fey GH | 1999 | Hepatology1999,30,3: | 1 |
| 14 | Doctor, what are my chances of having a positive sentinel node? A validated nomogrant for risk estimation 显示文摘 | Bevilacqua JL Kattan MW Fey JV | 2007 | J Clin Oncol2007,25,24: | 1 |
| 15 | Possible causes of inconclusive results on CT-guided thoracic and abdominal biopsies显示文摘 | Sheiman RG Fey C Mcnicholas M | 1998 | AJR1998,170,: | 1 |
| 16 | Involvement of Fas (APOI/CD95)during photodynamic-therapy-mediated apoptosis in homan epidermoid esxcinonla A431 cells显示文摘 | Ahmad N Gupta S Feyes DK | 2000 | J Invest Dermatol2000,115,6: | 1 |
| 17 | External sources of knowledge, governance mode and R&D performance显示文摘 | Fey C Birkinshaw J | 2005 | Journal of Management2005,,31: | 1 |
| 18 | External sources of knowl?edge, governance mode, and R&D performance显示文摘 | FEY C F BIRKINSHAWJ | 2005 | Jour?nal of Management2005,31,4: | 1 |
| 19 | Green tea constituent epigallocatechin-3-gallate and induction of apoptosis and cell cycle arrest in human carcinoma cells显示文摘 | Ahmad N Feyes DK Nieminen AL | 1997 | Natl Cancer Inst1997,89,24: | 1 |
| 20 | Green tea constituent epigallocatechin-3-gallate and induction of apoptosis and cell cycle arrest in human carcinoma cells 显示文摘 | Ahmad N Feyes DK Nieminen AL | 1997 | J Natl Caner Inst1997,89,24: | 1 |