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| 1 | Well-differentiated endocrine tumor of the distal common bile duct: a case study and literature review显示文摘 | Gabriella Nesi Antonella Lombardi Giacomo Batignani Ferdinando Ficari Carlos A. Rubio Francesco Tonelli | 2006 | Virchows Archiv2006，，1： | 2 |
| 2 | Treatment of desmoids and mesenteric fibromatosis in familial adenomatous polyposis with raloxifene显示文摘 | TONELLI F FICARI F VALANZANO R | 2003 | Tumori2003，89，： | 1 |
| 3 | Treatment of desmoids and mesenteric fibromatosis in familial adenomatous polyposis withraloxifene 显示文摘 | Tonelli F Ficari F Valanzano R | 2003 | Tumori2003，89，4： | 1 |
| 4 | Intramuscular hemangioma:problems of differential diagnosis from angiosarcoma显示文摘 | Valanzano R Ficari F Tonelli F | 1989 | Minerva Chir1989，44，： | 1 |
| 5 | Restorative Proctocolectomy or Rectum-Preserving Surgery in Patients with Familial Adenomatous Polyposis: Results of a Prospective Study显示文摘 | Francesco Tonelli Rosa Valanzano Iacopo Monaci Paolo Mazzoni Alessandro Anastasi Ferdinando Ficari | 1997 | World Journal of Surgery1997，，6： | 1 |
| 6 | APC gene mutations and colorectal adenomatosis in familial adenomatous polyposis显示文摘 | Ficari F Cama A Valanzano R | 2000 | Br J Cancer2000，82，2： | 1 |
| 7 | APC gene mutations and colorectal adenomatosis in familial adenomatous Polyposis显示文摘 | Ficari F Cama A Valanzano R | 2000 | Br J Cancer2000，82，2： | 1 |
| 8 | Anal carcinoma occurring in Crohn's disease patients with chronic anal fistula 显示文摘 | Ficari F Fazi M Garcea A | 2005 | Suppl Tumori2005，4，3： | 1 |
| 9 | Apc genemuttions and colorectal adenomatosis in familial adenomatous polyposis显示文摘 | Ficari F Cama A Valanzano R | 2000 | Br J Cancer2000，82，2： | 1 |
| 10 | APC gene mutations and colorectal adenomatosis in familial adenomatous polyposis 显示文摘 | Ficari F Cama A Valanzano R | 2000 | Br J Cancer2000，82，4： | 1 |
| 11 | Treatment of desmoids and mesenteric fibromatosis in familial adenomatous polyposis with raloxifene 显示文摘 | Tonelli F Ficari F Valanzano R | 2003 | Tumori2003，89，： | 1 |
| 12 | Multiplex gene expression profile in inflamed mucosa of patients with Crohn’s disease ileal localization: A pilot study显示文摘BACKGROUND Crohn’s disease (CD) is a complex disorder resulting from the interaction of genetic,environmental,and microbial factors.The pathogenic process may potentially affect any segment of the gastrointestinal tract,but a selective location in the terminal ileum was reported in 50% of patients.AIM To characterize clinical sub-phenotypes (colonic and/or ileal) within the same disease,in order to identify new therapeutic targets.METHODS 14 consecutive patients undergoing surgery for ileal CD were recruited for this study.Peripheral blood samples from each patient were collected and the main polymorphisms of the gene Card15/Nod2 (R702W,G908R,and 1007fs) were analyzed in each sample.In addition,tissue samples were taken from both the tract affected by CD and from the apparently healthy and disease-free margins (internal controls).We used a multiplex gene assay in specimens obtained from patients with ileal localization of CD to evaluate the simultaneous expression of 24 genes involved in the pathogenesis of the disease.We also processed surgery gut samples with routine light microscopy (LM) and transmission electron microscopy (TEM) techniques to evaluate their structural and ultrastructural features.RESULTS We found a significant increase of Th17 (IL17A and IL17F,IL 23R and CCR6) and Th1 (IFN-γ) gene expression in inflamed mucosa compared to non-inflamed sites of 14 CD patients.DEFB4 and HAMP,two genes coding for antimicrobial peptides,were also strongly activated in inflamed ileal mucosa,suggesting the overwhelming stimulation of epithelial cells by commensal microbiota.IFN-γ and CCR6 were more expressed in inflamed mucosa of CD patients with ileal localization compared with patients with colonic localization suggesting a more aggressive inflammation process in this site.Morphological analysis of the epithelial lining of Lieberkün crypts disclosed enhanced release activity from goblet mucocytes,whereas the lamina propria contained numerous cells pertaining to various lines.CONCLUSION We observed that the expression of ileal genes related to Th1 and Th17 activity is strongly activated as well as the expression of genes involved in microbiota regulation. | Francesco Giudici Letizia Lombardelli Edda Russo Tiziana Cavalli Daniela Zambonin Federica Logiodice Ornela Kullolli Lamberto Giusti Tatiana Bargellini Marilena Fazi Livia Biancone Stefano Scaringi Ann Maria Clemente Eloisa Perissi Giovanni Delfino Maria G Torcia Ferdinando Ficari Francesco Tonelli Marie-Pierre Piccinni Cecilia Malentacchi | 2019 | World Journal of Clinical Cases2019，7，17： | 1 |
| 13 | Ileal Pouch Adenomas and Carcinomas After Restorative Proctocolectomy for Familial Adenomatous Polyposis显示文摘 | Francesco Tonelli Ferdinando Ficari Tatiana Bargellini Rosa Valanzano | 2012 | Diseases of the Colon & Rectum2012，，3： | 1 |
| 14 | Treatment of perianal fistulas in Crohn's disease by local injection of antibody to TNF-alpha accounts for a favourable clinical response in selected cases: a pilot study显示文摘 | Asteria CR Ficari F Bagnoli S | 2006 | Seand J Gastroenterol2006，41，9： | 1 |
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