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您的检索式：作者名="Filipa Alves"
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| 1 | Characterization of monocarboxylate transporter activity in hepatocellular carcinoma显示文摘AIM: To assess the immunoexpression of hypoxiarelated markers in samples from cirrhosis and primary and metastatic hepatocellular carcinoma(HCC).METHODS: From a total of 5836 autopsies performed at the Pathology Department- University of Sao Paulo School of Medicine Hospital- from 2003 to 2009, 188 presented primary liver tumors. Immunohistochemical reactivity for monocarboxylate transporters(MCTs)-1, 2 and 4, CD147 and glucose transporter-1(GLUT1)was assessed in necropsies from 80 cases of HCC. Data were stored and analyzed using the IBM SPSS statistical software(version 19, IBM Company, Armonk, NY). All comparisons were examined for statistical significance using Pearson's χ2 test and Fisher's exact test(when n < 5). The threshold for significant P values was established as P < 0.05.RESULTS: Plasma membrane expression of MCT4 and overall expression of GLUT1 showed progressively higher expression from non-neoplastic to primary HCC and to metastases. In contrast, overall expression of MCT2 was progressively decreased from non-neoplastic to primary HCC and to metastases. MCT1(overall and plasma membrane expression), MCT2 and CD147 plasma membrane expression were associated with absence of cirrhosis, while plasma membrane expression of CD147 was also associated with absence of HBV infection. MCT2 overall expression was associated with lower liver weight, absence of metastasis and absence of abdominal dissemination. Additionally, MCT4 plasma membrane positivity was strongly associated with Ki-67 expression. CONCLUSION: MCT4 and GLUT1 appear to play a role in HCC progression, while MCT2 is lost during progression and associated with better prognosis. | Venncio AF Alves Céline Pinheiro Filipa Morais-Santos Aloisio Felipe-Silva Adhemar Longatto-Filho Fátima Baltazar | 2014 | World Journal of Gastroenterology2014，20，33： | 11 |
| 2 | Evaluation ofsolubility and partition properties of ampicillin-based ionicliquids显示文摘 | Catarina Florinda Joao M Filipa Alves | 2013 | International Journal of Pharmaceutics2013，456，2： | 1 |
| 3 | Short Report:Babywalkers Use and Age of Autonomous Sitting and Walking in Portuguese Infants显示文摘Babywalkers are wheeled seats for infants that support their weight and allow them to move around,pushing the floor with their feet or feet’s toes.The purpose of the present study was to verify if Portuguese infants that used babywalker gained or not temporal advantage compared to infants who did not use any instrument for learning to walk.Data were obtained through a structured questionnaire for parents,with closed questions.Results revealed that babywalkers use does not afford advantages in the acquisition of independent walk.The absence of association between seat and walk autonomously in babywalker users that also used other walk-helper(e.g.,harness belt)reinforces the hypothesis that the use of these equipments may disrupt normal process of transition between seat and walk in infants.Considering the sample of the present study,a great percentage of Portuguese parents still presume that the use of babywalkers or similar equipments are necessary for independent walking acquisition.Babywalkers should be discouraged as an instrument for independent walk learning,and be replaced by functional stimulation,like stepping reflex systematic practice. | David Catela Carolina Lagoiro Carolina Gonçalves Filipa Passadinhas Isabela Ribeiro Ana Paula Seabra | 2020 | Psychology Research2020，10，7： | 1 |
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