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| 1 | Is overhydration in peritoneal dialysis patients associated with cardiac mortality that might be reversible?显示文摘AIM To study the relationship between overhydration(OH) in peritoneal dialysis(PD) patients and cardiac mortality.METHODS OH, as measured by body composition monitor(BCM), is associated with increased mortality in dialysis patients. BCM has been used to guide treatment on the assumption that correcting OH will improve cardiac morbidity and mortality although data demonstrating causality that is reversible is limited. We wished to determine if OH in PD patients predicted cardiac mortality, and if there was a correlation between OH and cardiac troponin-T(cT n T) levels. Finally, we wished to determine if improving OH values would lead to a decrement in cT n T. All prevalent PD patients over the study period of 57 mo who had contemporaneous BCM and cT nT measurements were followed irrespective of transplantation or PD technique failure. We also studied a cohort of patients with who had severe OH(> +2L).The Fresenius Body Composition Monitor was used to obtain hydration parameters. cT nT levels were done as part of routine clinical care. Data was analysed using SPSS version 20.0.RESULTS There were 48 deaths in the 336 patients. The patients that died from cardiac or non-cardiac causes were similar with respect to their age, incidence of diabetes mellitus, gender, ethnicity and cause of renal failure. However, the patients with cardiac causes of death had significantly shorter dialysis vintage(10.3 mo vs 37.0 mo, P < 0.0001) and were significantly more overhydrated by BCM measurement(2.95 L vs 1.35 L, P < 0.05). The mean(standard error of the means) hydration status of the 336 patients was +1.15(0.12) L and the median [interquartile range(IQR)] cT nT level was 43.5(20-90) ng/L. The cT nT results were not normally distributed and were therefore transformed logarithmically. There was a statistically significant correlation between Log(cT nT) with the OH value(Spearman r value 0.425, P < 0.0001). We identified a sub-group of patients that were severely overhydrated; median(IQR) hydration at baseline was +2.7(2.3 to 3.7) L. They were followed up for a minimum of 6 mo. Reduction in OH values in these patients over 6 mo correlated with lowering of cT nT levels(Spearman r value 0.29, P < 0.02). CONCLUSION Patients that were overhydrated had higher cT nT, and had deaths that were more likely to be cardiac related. Reduction in OH correlated with lowering of cT nT. | Elizabeth Oei Klara Paudel Annemarie Visser Hazel Finney Stanley L Fan | 2016 | World Journal of Nephrology2016，5，5： | 4 |
| 2 | Granule size dis- tribution and chemical composition of starches from 12 soft wheat cultivars显示文摘 | Reaker M O Gaines C S Finney P L | 1998 | Cereal Chemistry1998，75，： | 1 |
| 3 | The NOTCH lig and, JAGGED-1, influences the development of primitive hematopoietic precursor cells显示文摘 | V arnum Finney B Purton L E Yu M | 1998 | Blood1998，91，11： | 1 |
| 4 | Measuring goal orientation in a work domain construct validity evidence for the 2 2 framework显示文摘 | Baranik L E Barron K E Finney S J | 2007 | Educational and Psychological Measurement2007，67，4： | 1 |
| 5 | Granule size distribution and chemical composition of starches from 12 soft wheat eultivars显示文摘 | Raeker M Gaines C S Finney P L | 1998 | Cereal Chemistry1998，75，： | 1 |
| 6 | The effect of catalyst loading and donor ligands in the Mn(Ⅲ) Salen catalysed chiral epoxidation of chromenes:Synthesis of BRL 55834显示文摘 | BELL D DAVIES M R FINNEY F J L | 1996 | Tetrahedron Lett1996，37，： | 1 |
| 7 | A radiation- driven model for crown fire spread 显示文摘 | BUTLER B W FINNEY M A ANDREWS P L | 2004 | Canada Journal of Forest Research2004，34，： | 1 |
| 8 | Pluripotent, cytokine-dependent,hematopoietic stem cells are immortalized by constitutive Notch1 signaling显示文摘 | Varnum - Finney B Xu L Brashem - Stein C | 2000 | Nat Med2000，6，11： | 1 |
| 9 | Experiment Micromilling: Reduction of Tempering Time of Wheat from 18-24Hours to 30 Minutes显示文摘 | Finney K F Bohe L C | 1985 | Cereal Chem1985，62，6： | 1 |
| 10 | The Pharmaco Logical Properties of Glycyrrhetinic Acid Hydrogen Succinate( Disodium Salt) 显示文摘 | Finney R S H Tarknoy A L | 1960 | J Pharm Pharmacol1960，12，： | 1 |
| 11 | C5a enhances dysregulated inflammatory and angiogenic responses to malaria in vitro: potential implications for placental malaria 显示文摘 | Conroy A Serghides L Finney C | 2009 | PLoS One2009，4，3： | 1 |
| 12 | Organic carbon atios (δ^13 C) of Arctic Amerasian Continental shelf sediments显示文摘 | Naidu A S Cooper L W Finney B P | 2000 | Earth Sciences2000，89，： | 1 |
| 13 | Bulk density and fuel loads of ponderosa pine and white fire forest floors : impacts of leaf morpholo- gy显示文摘 | Stephens S L Finney M A Schantz H | 2004 | Northwest Science2004，78，： | 1 |
| 14 | Selenium metabolism in cancer cells: the combined application of XAS and XFM techniques to the problem of selenium speciation in biological systems显示文摘 | Weekley CM Aitken JB Finney L | 2013 | Nu- trients2013，21，： | 1 |
| 15 | Effect of variations intempering on micromilling of hard winter wheat显示文摘 | POMERANZ Y BOLTE L C FINNEY K F | 1985 | Cereal Chem1985，62，： | 1 |
| 16 | Granule size distribution and chemical composition of starches from soft wheat cultivars显示文摘 | Raeker M O Gaines C S Finney P L | 1998 | Cereal Chem1998，75，5： | 1 |
| 17 | Transition metal speciation in the cell:Insights from the chemistry of metal ion receptors显示文摘 | FINNEY L A O'HALLORAN T V | 2003 | Science2003，300，5621： | 1 |
| 18 | Perceived helpfulness and impact of social support pro- vided by family, friends, and health care providers to women newly diagnosed with breast cancer显示文摘 | Arora N K Finney Rutten L J Gustafson D H | 2007 | Psy- chooncology2007，16，5： | 1 |
| 19 | Cancer prevention information seeking:a signal detection analysis of data from the cancer information service 显示文摘 | Sullivan H W Finney R L | 2009 | J Health Commun2009，14，8： | 1 |
| 20 | Experiment micromillingReduc- tion of tempering time of wheat from 1824 hours to 30 mi- nutes显示文摘 | FINNEY K F BOLTE L C | 1985 | Cereal Chem1985，62，6： | 1 |
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