|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Hepatitis C virus and diffuse large B-cell lymphoma: Pathogenesis, behavior and treatment显示文摘A significant association between hepatitis C virus(HCV) infection and B-cell lymphoma has been reported by epidemiological studies, most of them describing a strong relationship between indolent lymphomas and HCV. Furthermore, the curative potential of antiviral therapy on HCV related indolent lymphomas supports a specific role for the virus in lymphomagenesis. These observations are reinforced by numerous laboratory experiments that led to several hypothetical models of B-cell transformation by HCV. Diffuse large B-cell lymphoma(DLBCL), the most common lymphoma subtype in the western countries, has been associated to HCV infection despite its aggressive nature. This association seems particularly prominent in some geographical areas. Clinical presentation of HCV-associated DLBCL has consistently been reported to differ from the HCVnegative counterpart. Nevertheless, histopathology, tolerance to standard-of-care chemo-immunotherapy(R-CHOP or CHOP-like regimens) and final outcome of HCV-positive DLBCL patients is still matter of debate.Addition of rituximab has been described to enhance viral replication but the probability of severe hepatic complications remains low, with some exceptions(i.e., hepatitis B virus or immune immunodeficiency virus coinfected patients, presence of grade > 2 transaminases elevation, cirrhosis or hepatocarcinoma). HCV viral load in this setting is not necessarily directly associated with liver damage. Overall, treatment of HCV associated DLBCL should be performed in an interdisciplinary approach with hepatologists and hematologists with close monitoring of liver function. Available reports reveal that the final outcome of HCV-positive DLBCL that receive standard immunochemotherapy is not inferior to their HCV-negative counterpart. This review summarizes data on epidemiology, pathogenesis and therapeutic approach on HCV-associated DLBCL. Several issues that are matter of debate like clinical management of patients with transaminase elevation, criteria for discontinuing or starting immuno-chemotherapy, as well as the exact role of monoclonal antibodies will be analyzed. | Carlo Visco Silvia Finotto | 2014 | World Journal of Gastroenterology2014，20，32： | 6 |
| 2 | Treatment of allergic airway inflammation and hyperresponsiveness by antisense-induced local blockade of GATA-3 expression 显示文摘 | Finotto S Sanctis GT Lehr HA | 2001 | J Exp Med2001，193，11： | 1 |
| 3 | 显示文摘 | Finotto S Neurath MF Glickman JN | 2002 | Science2002，295，： | 1 |
| 4 | TNF-α production by eosinophils in upper airways inflammation (nasal polyposis) 显示文摘 | Finotto S Ohno I Marshall JS | 1994 | Immunol1994，153，5： | 1 |
| 5 | 显示文摘 | Finotto S Markus F Neurath MF | 2002 | Science2002，295，： | 1 |
| 6 | Combination of rituximab,bendamustine,and cytarabine for patients with mantle-cell non-Hodgkin lymphomaineligible for intensive regimens or autologous transplantation显示文摘 | VISCO C FINOTTO S ZAMBELLO R | 2013 | J Clin Oncol2013，31，： | 1 |
| 7 | Treatment of allergic airway inflammation and hyperresponsiveness by antisense-induced local blockade of GATA-3 expression显示文摘 | Finotto S De Sanctis GT Lehr HA | 2001 | J Exp Med2001，193，11： | 1 |
| 8 | Development of sponta-neous airway changes consistent with human asthma in mice lacking T-bet 显示文摘 | Finotto S Neurath MF Glickman JN | 2002 | Science2002，295，5553： | 1 |
| 9 | Vaccinationwith peptide mimetics of the gp41 prehairpin fusionintermediate yields neutralizing antisera against HIV-1isolates 显示文摘 | Bianchi E Joyce JG Miller MD Liang XP Finotto MA McKenna P Citron MA Hepler RW Hrin R Nahas D Wu CW Montefiori D Shiver JW Kim PS | 2010 | Proc Natl Acad Sci USA2010，107，10： | 1 |
| 10 | 显示文摘 | Neurath MF Weigmann B Finotto S | 2002 | J Exp Med2002，195，9： | 1 |
| 11 | T cell directives for transcriptional regulation in asthma显示文摘 | Susetta Finotto Laurie Glimcher | 2004 | Springer Seminars in Immunopathology (-)2004，，3： | 1 |
| 12 | Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo显示文摘 | Atreya R Mudter J Finotto S | 2000 | Nat Med2000，6，5： | 1 |
| 13 | Granulocyte/macrophage colony stimulating gene expression by eosinophils in nasal polyposis显示文摘 | Ohno I Lea R Finotto S | 1991 | Am Jrespir Cell Mol Biol1991，5，： | 1 |
| 14 | The emerging role of T cell cytokines in non-small cell lung cancer 显示文摘 | Neurath MF Finotto S | 2012 | Cytokine Growth Factor Rev2012，23，6： | 1 |
| 15 | IL-6 signaling in autoimmunity,chronic inflammation and inflammation-associated cancer显示文摘 | Neurath M F Finotto S | 2011 | Cytokine Growth Factor Rev2011，22，2： | 1 |
| 16 | Development of spontaneous airway changes consistant with human asthma in mice lacking T - bet 显示文摘 | Finotto S Neurath MF Glickman JN | 2002 | Science2002，295，5553： | 1 |
| 17 | Local blockade of IL-6Rsignaling induces lung CD4 + T cell apoptosis in a murine mode 1of asthma via regulatory T cells显示文摘 | Finotto S Eigenbrod T Karwot R | 2007 | Int Immunol2007，19，6： | 1 |
| 18 | The role of Th1/Th2 polarization in mucosal immunity显示文摘 | Neurath MF Finotto S Glimcher LH | | 0，，： | 1 |
| 19 | IL-6 signaling in autoimmunity,chronic inflammation and inflammation-associated cancer显示文摘 | Neurath MF Finotto S | | 0，，02： | 1 |
| 20 | Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet显示文摘 | Finotto S Neurath MF Glickman JN | 2002 | Science2002，295，5553： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员