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| 1 | Prognostic significance of tumor immune microenvironment and immunotherapy:Novel insights and future perspectives in gastric cancer显示文摘Despite a decrease in gastric cancer incidence, the development of novel biologic agents and combined therapeutic strategies, the prognosis of gastric cancer remains poor. Recently, the introduction of modern immunotherapy, especially using immune checkpoint inhibitors, led to an improved prognosis in many cancers. The use of immunotherapy was also associated with manageable adverse event profiles and promising results in the treatment of patients with gastric cancer, especially in heavily pretreated patients. These data have led to an accelerated approval of some checkpoint inhibitors in this setting. Understanding the complex relationship between the host immune microenvironment and tumor and the immune escape phenomenon leading to cancer occurrence and progression will subsequently lead to the identification of prognostic immune markers. Furthermore, this understanding will result in the discovery of both new mechanisms for blocking tumor immunosuppressive signals and pathways to stimulate the local immune response by targeting and modulating different subsets of immune cells. Due to the molecular heterogeneity of gastric cancers associated with differentclinico-biologic parameters, immune markers expression and prognosis, novel immunotherapy algorithms should be personalized and addressed to selected subsets of gastric tumors, which have been proven to elicit the best clinical responses. Future perspectives in the treatment of gastric cancer include tailored dual immunotherapies or a combination of immunotherapy with other targeted agents with synergistic antitumor effects. | Daniela Cornelia Lazǎr Mihaela Flavia Avram Ioan Romosan Mǎrioara Cornianu Sorina Tǎan Adrian Goldis | 2018 | World Journal of Gastroenterology2018，24，32： | 24 |
| 2 | Therapeutic and prophylactic thalidomide in TNBS-induced colitis: Synergistic effects on TNF-α, IL-12 and VEGF production显示文摘AIM: To evaluated the therapeutic and prophylactic effect of thalidomide on 2, 4, 6-trinitrobenzene sulfonic acid (TNBS)-induced colitis. Thalidomide has been reported to downregulate the expression of tumor necrosis factor a (TNF-α), IL-12, and vascular endothelial growth factor (VEGF), hallmarks of intestinal inflammation in Crohn's disease (CD). METHODS: Male Wistar rats were divided in five groups of ten animals each. Four groups received a rectal infusion of TNBS in ethanol. The first group was sacrificed 7 d after colitis induction. The second and third groups received either thalidomide or placebo by gavage and were sacrificed at 14 d. The fourth group received thalidomide 6 h before TNBS administration, and was sacrificed 7 d after induction. The fifth group acted as the control group and colitis was not induced. Histological inflammatory scores of the colon were performed and lamina propria CD4+ T cells, macrophages, and VEGF+ cells were detected by immunohistochemistry. TNF-a and IL-12 were quantified in the supernatant of organ cultures by ELISA. RESULTS: Significant reduction in the inflammatory score and in the percentage of VEGF+ cells was observed in the group treated with thalidomide compared with animals not treated with thalidomide. Both TNF-αand IL-12 levels were significantly reduced among TNBS induced colitis animals treated with thalidomide compared with animals that did not receive thalidomide. TNF-αlevels were also significantly reduced among the animals receiving thalidomide prophylaxis compared with untreated animals with TNBS-induced colitis. Intestinal levels of TNF-αand IL-12 were significantly correlated with the inflammatory score and the number of VEGF+ cells. CONCLUSION: Thalidomide significantly attenuates TNBS-induced colitis by inhibiting the intestinal production of TNF-α, IL-12, and VEGF. This effect may support the use of thalidomide as an alternate approach in selected patients with CD. | Ana Teresa Carvalho Heitor Souza Antonio Jose Carneiro Morgana Castelo-Branco Kalil Madi Alberto Schanaider Flavia Silva Fernando Antonio Pereira Júnior Márcia G Pereira Cláudio Tortori Ilana Dines Jane Carvalho Eduardo Rocha Celeste Elia | 2007 | World Journal of Gastroenterology2007，13，15： | 6 |
| 3 | An MMIC pulse generator using dual nonlinear transmission lines 显示文摘 | KINTIS M XING L FLAVIA F | 2007 | IEEE Microwave and Wireless Components Letters2007，17，6： | 1 |
| 4 | Seasonal changes of ener- gy reserves in Bulimulus tenuissimus (d' Orbigny, 1835 )(Mollusca, Bulimulidae)显示文摘 | Lidiane S Liliane M Flavia OJ et ol | 2012 | Anim Bioi2012，62，1： | 1 |
| 5 | Transformational Leaders and Work Performance: The Mediating Roles of Identification and Self-efficacy 显示文摘 | Flavia C Valter M Jane B | 2013 | Academy of Management Journal2013，10，4： | 1 |
| 6 | The relationship between group a streptococcal infections and Tourette syndrome: a study on a large service-based cohort显示文摘 | Davide M Flavia C Maura B | 2011 | Dev Med Child Neuro12011，53，10： | 1 |
| 7 | Intelligent drug delivery systems obtained by radiation显示文摘 | Flavia M Olga Z H Erzsebet T | 1998 | Radiation Physical Chemistry1998，52，6： | 1 |
| 8 | Fluoride uptake and acid resistance of enamel irradiated with Er: YAG laser 显示文摘 | Flavia MB Denise MZ Romeu M | 2008 | Laser Med Sci2008，23，2： | 1 |
| 9 | Biotransformations of cinnamic and ferulic acid with actinomycetes显示文摘 | Flavia M Cristina B | 2004 | Enzyme and Microbial Technology2004，34，： | 1 |
| 10 | Use of double bulk cur- rent injection for susceptibility testing of avionics显示文摘 | Flavia G Giordano S Filippo M | 2008 | IEEE Transactions on Electromagnetic Compatibility2008，50，3： | 1 |
| 11 | Measuring the sustainability of pension sys- tems through a micro simulation model the case of italy显示文摘 | FLAVIA C M | 2009 | Enepri Research Report2009，66，2： | 1 |
| 12 | Diversity and pharma- ceutical screening of fungi from benthic mats of Antarctic lakes 显示文摘 | Mara B Jose L R Flavia M | 2009 | Mar Genom2009，2，： | 1 |
| 13 | Psychosocial adjustment to orthotopic liver transplantation in 266 recipients显示文摘 | BLANCH J SUREDA B FLAVIA M | 2004 | Liver Transpl2004，10，2： | 1 |
| 14 | Conglomerated masses of silicosis in sandhlasters: High-resolution CT fndings显示文摘 | EDSON M ANGELA F FLAVIA S | 2006 | European Journal of Radiology2006，59，： | 1 |
| 15 | IL-6 -deficient mice show impaired inflammatory response in a model of myosin induced experimental myositis 显示文摘 | FLAVIA S MANNELLA F MARINO M | 2006 | Journal of Neuroimmunology2006，176，： | 1 |
| 16 | Biofilm development and cell death in the marine bacterium Pseudoalteromona tunicate显示文摘 | ANNE M P FLAVIA E DORALYN D S | 2004 | Applied and Environmental Microbiology2004，7，70： | 1 |
| 17 | TGF-β1 and IL-10 modulate IL-1β-induced membrane and soluble ICAM-1 in human myoblasts显示文摘 | Mariapaola M Flavia S Francesca M | 2003 | J Neuroimmunol2003，134，1： | 1 |
| 18 | Conglomerated masses of silicosis in sandblastersz High-resolution CT ndings显示文摘 | EDSON M ANGELA F FLAVIA S | 2006 | European Journal of Radiology2006，59，： | 1 |
| 19 | miR-221&222 Regulate TRAIL Resistance and Enhance Tumorigenicity through PTEN and TIMP3 Downregulation显示文摘 | Michela Garofalo Gianpiero Di Leva Giulia Romano Gerard Nuovo Sung-Suk Suh Apollinaire Ngankeu Cristian Taccioli Flavia Pichiorri Hansjuerg Alder Paola Secchiero Pierluigi Gasparini Arianna Gonelli Stefan Costinean Mario Acunzo Gerolama Condorelli Carlo M | 2009 | Cancer Cell2009，，6： | 1 |
| 20 | Determination of ethanol in fuel ethanol and beverages by Fourier transform(FT)-near infrared and FTRaman spectrometries显示文摘 | Leornardo S M Flavia C C O Paulo A Z S | 2003 | Analytica Chimica Acta2003，493，： | 1 |
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