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| 1 | 普罗布考和抗氧化维生素不影响体外实验条件下内皮细胞的白细胞粘附显示文摘为探讨预防动脉粥样硬化的药物普罗布考、维生素C和维生素E是否抑制内皮细胞表面粘附分子表达和白细胞—内皮细胞的粘附 ,以及这种抑制是否通过影响核因子 -κB的活性来实现的 ,在液体流动小室中进行细胞粘附实验 ;用ELISA方法测定内皮细胞粘附分子E -选择素的表达 ;用电泳迁移率分析测定内皮细胞核因子 -κB的活性。经肿瘤坏死因子α刺激的内皮细胞核因子 -κB活性增加 ,粘附分子E -选择素的表达上调 (是基础水平的 3.5倍 ) ,其表面HL6 0细胞的粘附增加 (是基础水平的 4~ 2 6倍 ) ,而抗氧化剂PDTC使所有这些变化都受到抑制。PDTC浓度为 18μmol L时对粘附分子E -选择素的表达呈最大半抑制 ;PDTC浓度为 5 2 μmol L时对内皮细胞表面HL6 0细胞的粘附呈最大半抑制。普罗布考、维生素C和维生素E对肿瘤坏死因子α诱导的粘附分子表达和HL6 0细胞与内皮细胞的粘附没有作用 ;对核因子 -κB的活性没有影响。临床上常用的这三种抗氧化剂并未影响作为动脉粥样硬化始动机制之一的E -选择素介导的白细胞 -内皮细胞粘附水平。 | 黄虔 Grfe M Grafe K Fleck E | 2001 | 中国动脉硬化杂志2001，9，2： | 2 |
| 2 | Riluzole preserves motor function in a transgenic model of familial amyotrophic lateral sclerosis显示文摘 | Gumey M E Fleck T J Himes C S | 1998 | Neurology1998，50，： | 1 |
| 3 | A crystal plasticity model for ferroelectrics 显示文摘 | HUBER J E FLECK N A MCMEEKING R M | 1999 | Ferroelectrics1999，228，： | 1 |
| 4 | A constitutive model for ferroelectric polycrystals 显示文摘 | HUBER J E FLECK N A LANDIS C M | 1999 | J Mmech Phys Solids1999，47，： | 1 |
| 5 | Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin added to pioglitazone in patients with type-2 diabetes: a randomized, double-blind, placebo-controlled study 显示文摘 | PRATLEY R E REUSCH J E FLECK P R | 2009 | Curr Med Res Opin2009，25，10： | 1 |
| 6 | Body of evidence to support a protective role for lutein and zeaxanthin in delaying chronic diseases显示文摘 | MARES-PERTMAN J A MILLEN A E FLECK T L | 2002 | J Nutr2002，132，3： | 1 |
| 7 | Analytical study for atomization of biodiesels and their blends in a typical injector: surface tension and viscosity effects显示文摘 | Ejim C E Fleck B A Amirfazli A | 2007 | Fuel2007，86，1011： | 1 |
| 8 | Geologic setting and genesis of the Mule Canyon low-sulfidation epithermal gold-silver deposit, north-central Nevada显示文摘 | John D A Hofstra A H Fleck R J Brummer J E Saderholm E C | 2003 | Econ Geol2003，98，2： | 1 |
| 9 | Anti-promthrombin antibodies and the lupus anticoagulant 显示文摘 | Fleck E Rapaport SI Rao LV | 1988 | Blood1988，72，2： | 1 |
| 10 | Small-scale self-focusing effects in a high power glass laser amplifier显示文摘 | Morris J R Bliss E S | 1978 | IEEE J Q E1978，14，5： | 1 |
| 11 | Ubiquitin genes are differentially regulated in protoplast-derived cultures of Nicotiana sylvestris and in response to various stresses显示文摘 | Pascal Genschik Yves Parmentier Andrée Durr Jacqueline Marbach Marie-Claire Criqui Elisabeth Jamet Jacqueline Fleck | 1992 | Plant Molecular Biology1992，，5： | 1 |
| 12 | Aripiprazole aug- mentation in treatment-resistant bipolar depression:early re- sponse and development of akathisia 显示文摘 | KEMP D E GILMER W S FLECK J | 2007 | Prog Neuropsycho- pharmacol Biol Psychiatry2007，31，2： | 1 |
| 13 | The incidence of reoperations inpacemaker recipients显示文摘 | Fleck T Khazen C Wolner E | 2006 | Heart Surg Forum2006，9，5： | 1 |
| 14 | A non-thiazolidinedione partial peroxisome proliferator-activated receptor gamma ligand inhibits vascular smooth muscle cell growth显示文摘 | Bruemmer D Berger JP Liu J Kintscher U Wakino S Fleck E | 2003 | Eur J Pharmacol2003，466，： | 1 |
| 15 | A randomised prospective comparison of operative peripheral iridectomy and Nd:YAG laser iridotomy treatment of acute angle closure glaucoma:3 year visual acuity and intraocular pressure control outcome 显示文摘 | Fleck BW Wright E Fairley EA | 1997 | Br J Ophthalmol1997，81，10： | 1 |
| 16 | Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin in patients with type 2 diabetes inadequately controlled by glyburide monotherapy显示文摘 | Pratley R E ipnes M S Fleck P R etal | 2009 | Diabetes Obes Metab2009，11，2： | 1 |
| 17 | Defective myocardial carnitine metabolism in conjestive heart failure secondary to dilated cardiomyopathy and tocoronary,hypertensive and valvular heart disease显示文摘 | Regitz V Shug AL Fleck E | 1990 | Am J Cardiol1990，65，11： | 1 |
| 18 | Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin added to pioglitazone in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled study显示文摘 | Pratley R E Reusch J E B Fleck P R | 2009 | Current Medical Research and Opinion2009，25，10： | 1 |
| 19 | Reti- nopathy of prematurity in smalll-for-gestational age infants com- pared with those of appropriate size for gestational age 显示文摘 | Dhaliwal CA Fleck BW Wright E Graham C McIntosh N | 2009 | Arch Dis Child Fetal Neonatal Ed2009，94，3： | 1 |
| 20 | Defective myocardial carnitine metabolism in congestive heart failure secondary to dilated cardiomyopathy and to coronary,hypert ensive and valvular heart diseases显示文摘 | Regitz V Shug AL Fleck E | 1990 | Am J Cardiol1990，65，11： | 1 |
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