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| 1 | Is osteoporosis a peculiar association with primary biliary cirrhosis?显示文摘AIM: (1) To compare the prevalence of osteoporosis (t-score ≤-2.5 SD) between stage Ⅳ PBC patients, and two groups of age- and sex-matched controls: one with hepatitis C virus (HCV)-related cirrhosis, and the other one consisting of a group of healthy subjects from the general population; (2) to identify the main risk factors for the development of bone loss.METHODS: Thirty-five stage Ⅳ PBC patients (mean age 52.5±10 years), 49 females with HCV-related cirrhosis (mean age 52.9±5.8 years) and 33 healthy females (mean age 51.8+2.22 years) were enrolled in the study. Bone metabolism was evaluated by measuring serum calcium corrected for serum albumin (Ca corr.), 25-hydroxy vitamin D (25-OH vit D), parathyroid hormone, osteocalcin.Bone mineral density (BMD) was assessed at the lumbar spine by dual-photon X-ray absorptiometry.RESULTS: Osteoporosis was present in 5/35 PBC patients (14.2%) and in 7/49 HCV-related cirrhotic patients (14.3%),without any statistical difference between the two groups.Among healthy control subjects, none had osteoporosis.No difference was found between the three groups in serum parameters of bone metabolism. Univariate analysis showed that menopausal state and low BMI were significantly correlated with osteoporosis. Multivariate regression analysis showed that menopausal status, BMI <23, and old age were independent variables significantly correlated with osteoporosis.CONCLUSION: PBC in itself has no negative influence on BMD. End-stage liver disease patients carry a disease-specific risk for osteoporosis, but have an effective risk of bone loss in relation to individual potential risk for each patient. A practical message should be taken into account, that is, every effort should be made to prevent osteoporosis when a patient has simple osteopenia, or if it is a woman in or near menopausal age. | Annarosa Floreani Andrea Mega Valentina Camozzi Vincenzo Baldo Mario Plebani Patrizia Burra Giovanni Luisetto | 2005 | World Journal of Gastroenterology2005，11，34： | 7 |
| 2 | Hepatitis C and pregnancy显示文摘Acute hepatitis C is a rare event in pregnancy. The most common scenario is chronic hepatitis C virus(HCV) infection in pregnancy. During pregnancy in women with chronic HCV infection a significant reduction in mean alanine aminotransferase levels has been reported,with a rebound during the postpartum period. In few cases exacerbation of chronic hepatitis C has been reported in pregnancy. A cofactor that might play a role in the reduction of liver damage is the release of endogenous interferon from the placenta. Observations regarding serum HCV-RNA concentration have been variable.In some women HCV-RNA levels rise toward the end of pregnancy. In general,pregnancy does not have a negative effect on HCV infection. Conversely,chronic hepatitis does not appear to have an adverse effect on the course of pregnancy,or the birth weight of the newborn infant. The role of spontaneous abortion is approximately the same as in the general population. The overall rate of mother-to-child transmission for HCV is3%-5% if the mother is known to be anti-HCV positive.Co-infection with human immunodeficiency virus(HIV)increases the rate of mother-to-child transmission up to19.4%. Numerous risk factors for vertical transmission have been studied. In general,high viral load defined as at least 2.5 × 106viral RNA copies/mL,HIV co-infection,and invasive procedures are the most important factors. Both interferon and ribavirin are contraindicated during pregnancy. Viral clearance prior to pregnancy increases the likelihood that a woman remains nonviremic in pregnancy with a consequent reduced risk of vertical transmission. | Annarosa Floreani | 2013 | World Journal of Gastroenterology2013，19，40： | 7 |
| 3 | pregnane X receptor and constitutive androstane receptor modulate differently CYp3A-mediated metabolism in earlyand late-stage cholestasis显示文摘AIM To ascertain whether cholestasis affects the expression of two CYP3 A isoforms(CYP3 A1 and CYP3 A2) and of pregnane X receptor(PXR) and constitutive androstane receptor(CAR).METHODS Cholestasis was induced by bile duct ligation in 16 male Wistar rats; whereas 8 sham-operated rats were used as controls. Severity of cholestasis was assessed on histological examination of liver sections, and serum concentrations of albumin, AST, ALT, GGT, ALPK and bilirubin. Gene and protein expressions of PXR, CAR, CYP3 A1 and CYP3 A2 were assessed by means of q RT-PCR and Western blot, respectively. Alterations in CYP3 A activity were measured by calculating the kinetic parameters of 4-OH and 1'-OH-midazolam hydroxylation, marker reactions for CYP3 A enzymes.RESULTS The m RNA and protein expression of CYP3 A1 increased significantly in mild cholestasis(P < 0.01). At variance, m RNA and protein expression of CYP3 A2 didn't change in mild cholestasis, whereas the expression and activity of both CYP3 A1 and CYP3 A2 decreased dramatically when cholestasis became severe. Consistently with these observations, the nuclear expression of both PXR and CAR, which was measured because they both translocate into the cell nucleus after their activation, virtually disappeared in the late stage of cholestatic injury, after an initial increase. These results indicate that early-and late-stage cholestasis affects CYP3 Amediated drug metabolism differently, probably as consequence of the different activation of PXR and CAR.CONCLUSION Early-and late-stage cholestasis affects CYP3 Amediated drug metabolism differently. PXR and CAR might be targeted therapeutically to promote CYP3 Amediated liver detoxification. | Daniela Gabbia Arianna Dalla Pozza Laura Albertoni Roberta Lazzari Giorgia Zigiotto Maria Carrara Vincenzo Baldo Tatjana Baldovin Annarosa Floreani Sara De Martin | 2017 | World Journal of Gastroenterology2017，23，42： | 5 |
| 4 | Y chromosome loss in male patients with primary biliary cirrhosis显示文摘 | Ana Lleo Sabine Oertelt-Prigione Ilaria Bianchi Lisa Caliari Palma Finelli Monica Miozzo Roberta Lazzari Annarosa Floreani Francesca Donato Massimo Colombo M. Eric Gershwin Mauro Podda Pietro Invernizzi | 2013 | Journal of Autoimmunity2013，，： | 2 |
| 5 | Female patients in fertile age with chronic hepatitis C, easy genotype, and persistently normal transaminases have a 100% chance to reach a sustained virological response显示文摘 | Annarosa Floreani Nora Cazzagon Deris Gianni Boemo Tatjana Baldovin Vincenzo Baldo Joel Egoue Sara Antoniazzi Eliseo Minola | 2011 | European Journal of Gastroenterology & Hepatology2011，，11： | 2 |
| 6 | A study of the mμ opioid receptor gene polymorphism Al18G in patients with primary biliary cirrhosis with and without pruritus显示文摘 | Wei LX Floreani A Variola A | 2008 | Aeta Derm Venereol2008，88，4： | 1 |
| 7 | Plasma adiponectin levels in primary biliary cirrhosis:A novel perspective for link between hypercholesterolemia and protection against atherosclerosis显示文摘 | Floreani A Variola A Niro G | 2008 | Am J Gastroenterol2008，103，8： | 1 |
| 8 | Refractive index sensing with long-period grating fabricated in biconical tapered fibre显示文摘 | Allsop T Floreani F Jedrzejewski K | 2005 | Electron Lett2005，47，8： | 1 |
| 9 | Seroepidemiology of Hepatitis B and C Viruses in the General Population of Burkina Faso显示文摘 | Issoufou Tao Tegwindé R. Compaoré Birama Diarra Florencia Djigma Theodora M. Zohoncon Maléki Assih Djeneba Ouermi Virginio Pietra Simplice D. Karou Jacques Simpore Annarosa Floreani | 2014 | Hepatitis Research and Treatment2014，，： | 1 |
| 10 | Liver diseases in the elderly:an update显示文摘 | Floreani A | 2007 | Dig Dis2007，25，2： | 1 |
| 11 | Primary biliary cirrhosis in the elderly 显示文摘 | Floreani A Chiaramonte M Fabris P | 1991 | Recenti Prog Med1991，82，5： | 1 |
| 12 | Intrahepatic Cholestasis Of Pregnancy: New Insights Into Its Pathogenesis显示文摘 | Floreani A Caroli D Lazzari R | 2013 | J Matern Fetal Neonatal Med2013，12，12： | 1 |
| 13 | A 35-year follow-up of a large cohort of patients with primary biliary cirrhosis seen at a single centre显示文摘 | Floreani A Caroli D Variola A | | 0，，03： | 1 |
| 14 | New assays for quantitative determination of viral markers in management of chronic hepatitis B virus core gene mutations显示文摘 | Zoulin F limms L Floreani I Pichoud C | 1992 | J Clin Microbiol1992，30，5： | 1 |
| 15 | Further evidence for neuroprotective effects of melatonin显示文摘 | France D D Skaper S D Floreani M | 1999 | Adv Exp Med1999，467，： | 1 |
| 16 | Neurotrophins rescue cerebellar granule neurons from oxidative stress-mediated apoptotic death:selective involvement of phos-phatidylinositol 3-kinase and the mitogen-activated pro-tein kinase pathway 显示文摘 | Floreani M Negro A | 1998 | J Neurochem1998，70，5： | 1 |
| 17 | Endogenous Interferon-α Level is Increased in Hepatitis C Virus (HCV)-Positive Pregnant Women显示文摘 | Delia Maria Paternoster Anna Belligoli Nanhornguè Kimta Ngaradoumbe Silvia Visentin Riccardo Franco Stefano Fagiuoli Caterina Boldrin Giorgio Palù Vincenzo Baldo Annarosa Floreani | 2008 | Journal of Clinical Gastroenterology2008，，2： | 1 |
| 18 | Intrahepatic cholestasis of pregnancy: three novel MDR3 gene mutations 显示文摘 | Floreani A Carderi I Paternoster D | 2006 | Aliment Pharmacol Ther2006，23，11： | 1 |
| 19 | 显示文摘 | Floreani D A King L A | 1984 | J Phys Chem1984，88，： | 1 |
| 20 | 35-year follow-up of a large cohort of patients with primary biliary cirrhosis seen at a single centre 显示文摘 | Floreani A Caroli D Variola A | 2011 | Liver hat2011，31，3： | 1 |
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