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| 1 | Near-infrared fluorescence sentinel lymph node detection in gastric cancer: A pilot study显示文摘AIM: To investigate feasibility and accuracy of nearinfrared fluorescence imaging using indocyanine green: nanocolloid for sentinel lymph node(SLN) detection in gastric cancer.METHODS: A prospective, single-institution, phaseI feasibility trial was conducted. Patients suffering from gastric cancer and planned for gastrectomy were included. During surgery, a subserosal injection of 1.6 m L ICG:Nanocoll was administered around the tumor. NIR fluorescence imaging of the abdominal cavity was performed using the Mini-FLARE? NIR fluorescence imaging system. Lymphatic pathways and SLNs were visualized. Of every detected SLN, the corresponding lymph node station, signal-to-background ratio and histopathological diagnosis was determined. Patients underwent standard-of-care gastrectomy. Detected SLNs outside the standard dissection planes were also resected and evaluated.RESULTS: Twenty-six patients were enrolled. Four patients were excluded because distant metastases were found during surgery or due to technical failure of the injection. In 21 of the remaining 22 patients, at least 1 SLN was detected by NIR Fluorescence imaging(mean 3.1 SLNs; range 1-6). In 8 of the 21 patients, tumor-positive LNs were found. Overall accuracy of the technique was 90%(70%-99%; 95%CI), which decreased by higher p T-stage(100%, 100%, 100%, 90%, 0% for respectively Tx, T1, T2, T3, T4 tumors). All NIR-negative SLNs were completely effaced by tumor. Mean fluorescence signal-to-background ratio of SLNs was 4.4(range 1.4-19.8). In 8 of the 21 patients, SLNs outside the standard resection plane were identified, that contained malignant cells in 2 patients.CONCLUSION: This study shows successful use of ICG:Nanocoll as lymphatic tracer for SLN detection in gastric cancer. Moreover, tumor-containing LNs outside the standard dissection planes were identified. | Quirijn RJG Tummers Leonora SF Boogerd Wobbe O de Steur Floris PR Verbeek Martin C Boonstra Henricus JM Handgraaf John V Frangioni Cornelis JH van de Velde Henk H Hartgrink Alexander L Vahrmeijer | 2016 | World Journal of Gastroenterology2016，22，13： | 9 |
| 2 | The clinical efficacy of magnetic resonance with diffusion-weighted sequences in the assessment of acute cerebral ischemia显示文摘 | Floris R Giuliani V | 1999 | Radilo Med(Torino)1999，98，： | 1 |
| 3 | HPLC determination of pantothenic acid in royal jelly显示文摘 | Ciulu M Floris I Nurchi V M | | 0，，： | 1 |
| 4 | Differential effects of nitrogenous fertilizers on methane-consuming microbes in rice field and forest soils显示文摘 | Mohanty S R Bodelier P L Floris V | 2006 | Applied and Environmental Microbiology2006，72，2： | 1 |
| 5 | Correlation between melanogenic and catalase activity in in vitro human melanocytes:a synergic strategy against oxidative stress显示文摘 | Maresca V Flori E Briganti S | 2008 | Pigment Cell Melanoma Res2008，21，2： | 1 |
| 6 | General multifractal analysis of local entropies显示文摘 | FLORIS T EVGENY V | 2000 | Fundament Mathematics2000，165，： | 1 |
| 7 | Differential effects of nitrogenous fertilizers on methane-consuming microbes in rice field and forest soils 显示文摘 | Mohanty S R Bodelier L E Floris V | 2006 | Appl Environ Microbiol2006，72，： | 1 |
| 8 | The clinical efficacy of magnetic resonance with diffusion-weighted sequences in the assessment of acute cerebral ischemia显示文摘 | Bazzao A Floris R Giuliani V | 1999 | Radial Med1999，，98： | 1 |
| 9 | Ferritin light chain down-modulation generates depigmentation in human metastatic melanoma cells by influencing tyrosinase maturation显示文摘 | Maresca V Flori E Cardlnali G | 2006 | Journal of Cellular Physiology2006，206，3： | 1 |
| 10 | UVA-inducedmodification of catalase charge properties in the epider-mis is correlated with the skin phototype显示文摘 | Maresca V Flori E Briganti S | 2006 | J InvestDermatol2006，126，： | 1 |
| 11 | Rheumatoid arthritis is a heterogeneous disease evidence for differences in the activation of the STAT-l pathway between rheumatoid tissues显示文摘 | Tineke P K Floris A G Kasperkovitz P V | 2003 | Arthritis Rheum2003，48，8： | 1 |
| 12 | Highly luminescent water-soluble CdTe quantum dots 显示文摘 | SANDER F W INGMAR S FLORIS V D | 2003 | Nano Letters2003，3，04： | 1 |
| 13 | Vanadium and molybdenum peroxides: synthesis and catalytic activity in oxidation reactions 显示文摘 | Cont V Floris B | 2011 | Dalton Trans2011，40，7： | 1 |
| 14 | The clinical efficacy of magnetic resonance with diffusion-weighted sequences in the assessment of acute cerebral ischemia显示文摘 | Bozzao A Floris R Giuliani V | 1999 | Radiol Med (Torina)1999，98，3： | 1 |
| 15 | P38 regulates pigmentation via proteasomal degradation of tyrosinase显示文摘 | BELLEI B MARESCA V FLORI E | 2010 | J Biol Chem2010，285，10： | 1 |
| 16 | UVA-induced modification of eatalase charge properties in the epidermis is correlated with the skin phototype显示文摘 | Maresca V Flori E Briganti S | 2006 | J Invest Dermatol2006，126，： | 1 |
| 17 | Correlation between melanogenic and catalase activity in in vitro human melanocytes: a synergic strategy against oxidative stress 显示文摘 | Maresca V Flori E Briganti S | 2008 | Pigment Cell Melanoma Res2008，21，： | 1 |
| 18 | Correlation between melanogenic and catalase activity in in vitro human melanocytes:a synergic strategy against oxidative stress显示文摘 | Maresca V Flori E Briganti S | 2008 | Pigment Cell Melanoma Res2008，21，2： | 1 |
| 19 | Ferritin light chain down-modulation generates depigmentation in human metastatic melanoma cells by influencing tyrosinase maturation 显示文摘 | Maresca V Flori E Cardinali G | 2006 | Cell Physiol2006，206，3： | 1 |
| 20 | Theclinical Efficacy of Magnetic Resonance with Diffusion-Weighted Sequences in the Assessment of Acute Cerebral Ischemia显示文摘 | BOZZAO A FLORIS R CIULIANI V | 1999 | Radiol Med(Torina)1999，98，： | 1 |
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