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| 1 | Cell Cycle Regulatory Proteins in the Liver in Murine Trypanosoma Cruzi Infection 显示文摘 | Boumediene Bouzahzah Fnu Nagajyothi Mahalia S | 2006 | Landcs Bioscience2006，5，： | 1 |
| 2 | Efficacy of varicocelectomy in improving semen parameters:New Meta-analytical approach显示文摘 | Ashok A Fnu D Marcello C | | 0，，03： | 1 |
| 3 | Thrombotic microangiopathy after kidney transplantation: Expanding etiologic and pathogenetic spectra显示文摘Thrombotic microangiopathy(TMA)is an uncommon but serious complication that not only affects native kidneys but also transplanted kidneys.This review is specifically focused on post-transplant TMA(PT-TMA)involving kidney transplant recipients.Its reported prevalence in the latter population varies from 0.8%to 14%with adverse impacts on both graft and patient survival.It has many causes and associations,and the list of etiologic agents and associations is growing constantly.The pathogenesis is equally varied and a variety of pathogenetic pathways lead to the development of microvascular injury as the final common pathway.PT-TMA is categorized in many ways in order to facilitate its management.Ironically,more than one causes are contributory in PT-TMA and it is often difficult to pinpoint one particular cause in an individual case.Pathologically,the hallmark lesions are endothelial cell injury and intravascular thrombi affecting the microvasculature.Early diagnosis and classification of PT-TMA are imperative for optimal outcomes but are challenging for both clinicians and pathologists.The Banff classification has addressed this issue and has developed minimum diagnostic criteria for pathologic diagnosis of PT-TMA in the first phase.Management of the condition is also challenging and still largely empirical.It varies from simple maneuvers,such as plasmapheresis,drug withdrawal or modification,or dose reduction,to lifelong complement blockade,which is very expensive.A thorough understanding of the condition is imperative for an early diagnosis and quick treatment when the treatment is potentially effective.This review aims to increase the awareness of relevant stakeholders regarding this important,potentially treatable but under-recognized cause of kidney allograft dysfunction. | Muhammed Mubarak Amber Raza Rahma Rashid Fnu Sapna Shaheera Shakeel | 2024 | World Journal of Transplantation2024，14，1： | 0 |
| 4 | Global trends in hepatitis C-related hepatocellular carcinoma mortality:A public database analysis(1999-2019)显示文摘BACKGROUND Hepatitis C is the leading cause of chronic liver disease worldwide and it significantly contributes to the burden of hepatocellular carcinoma(HCC).However,there are marked variations in the incidence and mortality rates of HCC across different geographical regions.With the advent of new widely available treatment modalities,such as direct-acting antivirals,it is becoming increasingly imperative to understand the temporal and geographical trends in HCC mortality associated with Hepatitis C.Furthermore,gender disparities in HCC mortality related to Hepatitis C are a crucial,yet underexplored aspect that adds to the disease's global impact.While some studies shed light on gender-specific trends,there is a lack of comprehensive data on global and regional mortality rates,particularly those highlighting gender disparities.This gap in knowledge hinders the development of targeted interventions and resource allocation strategies.DISCUSSION The results of our study show an overall decline in the mortality rates of patients with hepatitis C-related HCC over the last two decades.Notably,females exhibited a remarkable decrease in mortality compared to males.Regionally,East Asia and the Pacific displayed a significant decline in mortality,while Europe and Central Asia witnessed an upward trend.Latin America and the Caribbean also experienced an increase in mortality rates.However,no significant difference was observed in the Middle East and North Africa.North America exhibited a notable upward trend.South Asia and Sub-Saharan Africa significantly declined throughout the study period.This raises the hope of identifying areas for implementing more targeted resources.Despite some progress,multiple challenges remain in meeting the WHO 2030 goal of eliminating viral hepatitis[24]. | Hassam Ali Fnu Vikash Vishali Moond Fatima Khalid Abdur Rehman Jamil Dushyant Singh Dahiya Amir Humza Sohail Manesh Kumar Gangwani Pratik Patel Sanjaya K Satapathy | 2024 | World Journal of Virology2024，13，1： | 0 |
| 5 | Atrial fibrillation and dementia: not just a coincidence显示文摘Atrial fibrillation(AF)is the most common form of cardiac arrhythmia,affecting 3 to 6 million people in the US,with an increased incidence in women and elderly,with its prevalence estimated to increase from 5.1 million in 2000 to 15.9 million in 2050 in the US population.[1]Age,hypertension,heart failure,myocardial infarction(MI),genetic factors,and associated systemic inflammatory states are well-established risk factors for the development of AF.[2–6]Lifestyle factors including alcohol consumption,smoking,obesity,sedentary lifestyle,and vigorous physical activity have also been implicated to contribute to the development of AF.[2,7–9]Studies suggest that AF drives up medical expenditure.[10]The European Society of Cardiology,based on the duration,responsiveness to treatment,and therapeutic attitude of the patient and physician,classifies AF into 4 types;when AF occurs and terminates by itself or by intervention within 7 days of onset,it is called paroxysmal AF;if sustained for more than a week,with or without intervention. | Udit Choubey Vasu Bansal Priyanshi Shah FNU Anamika Vasu Gupta Sweta Sahu Miran Rezhan Rohit Jain | 2023 | Journal of Geriatric Cardiology2023，20，9： | 0 |
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