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| 1 | Anti-inflammatory effects of bifidobacteria by inhibition of LPS-induced NF-κB activation显示文摘AIM: Different strains of bifidobacteria were analysed for their effects on HT-29 intestinal epithelial cells (IECs) in in vitro models both of the non-inflamed and inflamed intestinal epithelium. METHODS: A reporter gene system in HT-29 cells was used to measure levels of NF-KB activation after challenge with bifidobacteria or after bacterial pre-treatment following LPS challenge. IL-8 protein and pro-inflammatory gene expression was investigated using normal HT-29 cells. RESULTS: None of the bifidobacteria tested induced activation of nuclear factor KB (NF-KB) indicating that bifidobacteria themselves do not induce inflammatory events in IECs. However, six out of eight bifidobacteria tested inhibited lipopolysaccharide- (LPS-) induced NFKB activation in a dose- and strain-dependent manner. In contrast, NF-KB activation in response to challenge with tumor necrosis factor-α(TNF-α) was affected by none of the tested bifidobacteria, indicating that the inhibitory effect of bifidobacteria is specific for LPS-induced inflammation in IECs. As shown with two of the six inhibitionpositive bifidobacteria, LPS-induced inhibition of NFKB activation was accompanied by a dose-dependent decrease of interleukin 8 (IL-8) secretion and by lower mRNA levels for IL-8, TNF-a, cyclooxygenase 2 (Cox-2), and intercellular adhesion molecule 1 (ICAM-1). CONCLUSION: Some strains of bifidobacteria are effective in inhibiting LPS-induced inflammation and thus might be appropriate candidates for probiotic intervention in chronic intestinal inflammation. | Christian U Riedel Francis Foata David Philippe Oskar Adolfsson Bernhard J Eikmanns Stephanie Blum | 2006 | World Journal of Gastroenterology2006，12，23： | 14 |
| 2 | Bifidobacterium lactis attenuates onset of inflammation in a murine model of colitis显示文摘AIM: To assess the anti-inflammatory effect of the probiotic Bifidobacterium lactis (B. lactis) in an adoptive transfer model of colitis. METHODS: Donor and recipient mice received either B. lactis or bacterial culture medium as control (deMan Rogosa Sharpe) in drinking water for one week prior to transfer of a mix of naive and regulatory T cells until sacrifice. RESULTS: All recipient mice developed signs of colonic inflammation, but a significant reduction of weight loss was observed in B. lactis-fed recipient mice compared to control mice. Moreover, a trend toward a diminution of mucosal thickness and attenuated epithelial damage was revealed. Colonic expression of pro-inflammatory and T cell markers was significantly reduced in B. lactis-fed recipient mice compared to controls. Concomitantly, forkhead box protein 3, a marker of regulatory T cells, was significantly up-regulated by B. lactis. CONCLUSION: Daily oral administration of B. lactis was able to reduce inflammatory and T cells mediators and to promote regulatory T cells specific markers in a mouse model of colitis. | David Philippe Laurent Favre Francis Foata Oskar Adolfsson Genevieve Perruisseau-Carrier Karine Vidal Gloria Reuteler Johanna Dayer-Schneider Christoph Mueller Stéphanie Blum | 2011 | World Journal of Gastroenterology2011，17，4： | 12 |
| 3 | Interaction of bifdobae- teHa with Caco-2 cells--adhesion and impact on expression pro- files显示文摘 | Riedel C U Foata F Goldstein D R | 2006 | International Journal of Food Microbiology2006，110，1： | 1 |
| 4 | 电力变压器投资决策技术风险的财务影响评估显示文摘全寿命周期成本测算是一种经济分析过程,它评估产品从购置、拥有到处置的所有成本,计入将所有未来成本折算为净现值所需的折旧(净现值NPV或者成本)。为了做好全面分析,必须对变压器全寿命期内可能发生的成本进行很好的预测。有些成本是显而易见的,很容易被计算出(如铁芯损耗),而很多其他类型成本却要么无充分依据,或者尚未为人所知,特别是有些与故障风险相关的成本。除了原料成本之外,故障所导致的计划外检修可能会产生更为严重的财务和责任后果。因此对这种后果所致风险的正确评估是任何一个变压器群组资产管理战略的基石。从不同方案的各种角度,小故障、大故障、防火和运维成本增加等,审视几种典型变压器案例。同时,按照故障风险的净现值水平对不同投资选择(维持现状,更换或者修理)的财务优点进行比较。 | Christoph Haering Moritz Werner Marc Foata Ninil Ukhita 王翀(译) | 2017 | 电力与能源2017，38，5： | 1 |
| 5 | Computational methods for the analysis of explosions in oil-insulated electrical equipment显示文摘 | Foata M Iordanescu M Hardy C | 1988 | IEEE Transactions on Power Systems1988，3，1： | 1 |
| 6 | Estimating overpressures in pole-type distribution transformers,part Ⅰ:tank withstand evaluation显示文摘 | Hamel A Dastous J B Foata M | 2003 | IEEE Transactions on Power Delivery2003，18，1： | 1 |
| 7 | Estimating overpressures in pole-type distribution transformers,part Ⅱ:prediction tools显示文摘 | Dastous J B Foata M Hamel A | 2003 | IEEE Transactions on Power Delivery2003，18，1： | 1 |
| 8 | Numerical method for the investigation of fault containment and tank rupture of power transformers显示文摘 | Dastous J B Lanteigne J Foata M | 2010 | IEEE Transactions on Power Delivery2010，25，3： | 1 |
| 9 | Anti-inflammatory effects of Lacto-Wolfberry in a mouse model of experimental colitis显示文摘AIM: To investigate the anti-inflammatory properties of Lacto-Wolfberry (LWB), bothin vitro and using a mouse model of experimental colitis. METHODS: The effects of LWB on lipopolysaccharide (LPS)-induced reactive oxygen species (ROS) and interleukin (IL)-6 secretion were assessed in a murine macrophage cell line. in vitro assessment also included characterizing the effects of LWB on the activation of NF-E2 related 2 pathway and inhibition of tumor necrosis factor-α (TNF-α)-induced nuclear factor-κB (NFκB) activation, utilizing reporter cell lines. Following the in vitro assessment, the anti-inflammatory efficacy of an oral intervention with LWB was tested in vivo using a preclinical model of intestinal inflammation. Multiple outcomes including body weight, intestinal histology, colonic cytokine levels and anti-oxidative measures were investigated.RESULTS: LWB reduced the LPS-mediated inductionof ROS production [+LPS vs 1% LWB + LPS, 1590 ± 188.5 relative luminescence units (RLU) vs 389 ± 5.9 RLU, P < 0.001]. LWB was more effective than wolfberry alone in reducing LPS-induced IL-6 secretion in vitro (wolfberry vs 0.5% LWB, 15% ± 7.8% vs 64% ± 5%, P < 0.001). In addition, LWB increased reporter gene expression via the anti-oxidant response element activation (wolfberry vs LWB, 73% ± 6.9% vs 148% ± 28.3%, P < 0.001) and inhibited the TNF-α-induced activation of the NF-κB pathway (milk vs LWB, 10% ± 6.7% vs 35% ± 3.3%, P < 0.05). Furthermore, oral supplementation with LWB resulted in a reduction of macroscopic (-LWB vs +LWB, 5.39 ± 0.61 vs 3.66 ± 0.59, P = 0.0445) and histological scores (-LWB vs +LWB, 5.44 ± 0.32 vs 3.66 ± 0.59, P = 0.0087) in colitic mice. These effects were associated with a significant decrease in levels of inflammatory cytokines such as IL-1β (-LWB vs +LWB, 570 ± 245 μg/L vs 89 ± 38 μg/L, P = 0.0106), keratinocyte-derived chemokine/growth regulated protein-α (-LWB vs +LWB, 184 ± 49 μg/Lvs 75 ± 20 μg/L,P = 0.0244), IL-6 (-LWBvs +LWB, 318 ± 99 μg/L vs 117 ± 18 μg/L, P = 0.0315) and other pro-inflammatory proteins such as cyclooxygenase-2 (-LWB vs +LWB, 0.95 ± 0.12 AU vs 0.36 ± 0.11 AU, P = 0.0036) and phosphorylated signal transducer and activator of transcription-3 (-LWB vs +LWB, 0.51 ± 0.15 AU vs 0.1 ± 0.04 AU, P = 0.057). Moreover, antioxidant biomarkers, including expression of gene encoding for the glutathione peroxidase, in the colon and the plasma anti-oxidant capacity were significantly increased by supplementation with LWB (-LWB vs +LWB, 1.2 ± 0.21 mmol/L vs 2.1 ± 0.19 mmol/L, P = 0.0095).CONCLUSION: These results demonstrate the antiinflammatory properties of LWB and suggest that the underlying mechanism is at least in part due to NF-κB inhibition and improved anti-oxidative capacity. | David Philippe Viral Brahmbhatt Francis Foata Yen Saudan Patrick Serrant Stephanie Blum Jalil Benyacoub Karine Vidal | 2012 | World Journal of Gastroenterology2012，18，38： | 1 |
| 10 | Numerical method for the investigation of fault containment and tank rupture of power transformers显示文摘 | Dastous J B Lanteigne J Foata M | 2009 | IEEE Transactions on Power and Energy Society2009，25，1： | 1 |
| 11 | Computational methods for the analysis of explosions in oil-insulated electrical equipment显示文摘 | Foata M Iordanescu M Hardy C | 1988 | IEEE Transactions on Power Systems1988，3，1： | 1 |
| 12 | Estimating overpressures in pole-type distribution transformers,part I:tank withstand evaluation显示文摘 | Hamel A Dastous J-B Foata M | 2003 | IEEE Transactions on Power Delivery2003，18，1： | 1 |
| 13 | Estimating overpressures in pole-type distribution transformers,part II:prediction tools显示文摘 | Dastous J-B Foata M Hamel A | 2003 | IEEE Transactions on Power Delivery2003，18，1： | 1 |
| 14 | A Serpin from the gut bacteri- um Bifidobacterium longum inhibits eukaryotic elastase-like ser- ine proteases显示文摘 | Ivanov D Emonet C Foata F | 2006 | J Biol Chem2006，281，17： | 1 |
| 15 | Numerical method for the investigation of fault containment and tank rupture of power transformers显示文摘 | Dastous J-B Lanteigne J Foata M | 2010 | IEEE Transactions on Power Delivery2010，25，3： | 1 |
| 16 | Anti-inflammatory effects of Bifidobacteria by inhibition of LPS-induced NF-kappaB activation 显示文摘 | Riedel CU Foata F Philippe D | 2006 | World J Gastroentero12006，12，23： | 1 |
| 17 | Molecular modeling of the second extracellular loop of G-protein coupled receptors and its implication on structure-based virtual screening显示文摘 | de Greef C Foata N Engkvist O | | 0，，： | 1 |
| 18 | Computational methods for the analysis of explosions in oilinsulated electrical equipments 显示文摘 | M Foata M Iordaneseu C Hardy | 1988 | IEEE Transactions on Power Systems1988，3，1： | 1 |
| 19 | Interaction of bifidobacteria with Caco-2 cells-adhesion and impact on expression profiles 显示文摘 | Riedel C U Foata F Goldstein D R | 2006 | International Journal of Food Microbiology2006，110，1： | 1 |
| 20 | A Serpin from the gut bacterium Bifidobacterium longum inhibits eukaryotic elastase-like serine proteases显示文摘 | Ivanov D Emonet C Foata F | 2006 | J Biol Chem2006，281，25： | 1 |
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