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| 1 | Is it better to use two elastographic methods for liver fibrosis assessment?显示文摘AIM:To find out if by combining 2 ultrasound based elastographic methods:acoustic radiation force impulse(ARFI)elastography and transient elastography(TE),we can improve the prediction of fibrosis in patients with chronic hepatitis C.METHODS:Our study included 197 patients with chronic hepatitis C.In each patient,we performed,in the same session,liver stiffness(LS)measurements by means of TE and ARFI,respectively,and liver biopsy(LB),assessed according to the Metavir score.10 LS measurements were performed both by TE and ARFI;median values were calculated and expressed in kilopascals(kPa)and meters/second(m/s),respectively.Only TE and ARFI measurements with IQR<30%andSR≥60%were considered reliable.RESULTS:On LB 13(6.6%)patients had F0,32(16.2%) had F1,52(26.4%)had F2,47(23.9%)had F3,and 53(26.9%)had F4.A direct,strong correlation was found between TE measurements and fibrosis(r=0.741),between ARFI and fibrosis(r=0.730)and also between TE and ARFI(r=0.675).For predicting significant fibrosis(F≥2),for a cutoff of 6.7 kPa,TE had 77.5% sensitivity(Se)and 86.5%specificity(Sp)[area under the receiver operating characteristic curve(AUROC)0.87] and for a cutoff of 1.2 m/s,ARFI had 76.9%Se and 86.7%Sp(AUROC 0.84).For predicting cirrhosis(F=4),for a cutoff of 12.2 kPa,TE had 96.2%Se and 89.6% Sp(AUROC 0.97)and for a cutoff of 1.8 m/s,ARFI had 90.4%Se and 85.6%Sp(AUROC 0.91).When both elastographic methods were taken into consideration,for predicting significant fibrosis(F≥2),(TE≥6.7 kPa and ARFI≥1.2 m/s)we obtained 60.5%Se,93.3% Sp,96.8%positive predictive value(PPV),41.4%negative predictive value(NPV)and 68%accuracy,while for predicting cirrhosis(TE≥12.2 kPa and ARFI≥1.8 m/s) we obtained 84.9%Se,94.4%Sp,84.9%PPV,94.4% NPV and 91.8%accuracy.CONCLUSION:TE used in combination with ARFI is highly specific for predicting significant fibrosis;therefore when the two methods are concordant,liver biopsy can be avoided. | Ioan Sporea Roxana Sirli Alina Popescu Simona Bota Radu Badea Monica Lupsor Mircea Focsa Mirela Danila | 2011 | World Journal of Gastroenterology2011，17，33： | 11 |
| 2 | A comparative Raman spectroscopic study of natural gas hydrates collected at different geological sites显示文摘 | CHAZALLON B FOCSA C CHARLOU J L | 2007 | Chemical Geology2007，244，： | 1 |
| 3 | A comparative study of SiO2 deposited by PECVD and thermal method as passiva- tion for multicrystalline silicon solar cells显示文摘 | Panek P Drabczyk K Focsa A | 2009 | Mater Sci Eng B2009，165，12： | 1 |
| 4 | Thin film polycrystalline silicon solar cells on mullite ceramics显示文摘 | FOCSA A GORDON I AUGER J M | 2008 | Renewable Energy2008，33，2： | 1 |
| 5 | A comparative Raman spectroscopic study of natural gas hydrates collected at different geological sites显示文摘 | CHAZALLON B FOCSA C CHARLOU J L | 2007 | Chemical Geology2007，244，： | 1 |
| 6 | Thin film poly- crystalline silicon solar ceils on mullite ceramics 显示文摘 | FOCSA A GORDON I AUGER J M | 2008 | Renewable Energy2008，33，2： | 1 |
| 7 | Acomparative Raman spectroscopic study of natural gashydrates collected at different geological sites 显示文摘 | CHAZALLON B FOCSA C CHARLOU J L | 2007 | Chem Geo2007，244，： | 1 |
| 8 | A comparative study of SiO2 deposited by PECVD and thermal method as passivation for multicrystalline silicon solar cells 显示文摘 | PANEK P DRABCZYK K FOCSA A | 2009 | Mater Sci Eng B2009，165，12： | 1 |
| 9 | Characterization of la- ser-induced damage in silicon solar cells during selective ablation processes 显示文摘 | Poulain G Blanc D Focsa A | 2013 | Materials Science and Engincerng B-advarred Functional Solid-State Materials2013，178，： | 1 |
| 10 | A comparative Rarnan spectroscopic study of natural gas hydrates collected at different geological sites 显示文摘 | Chazallon B Focsa C Charlou J L Bourry C Donval J | 2007 | Chemical Geology2007，244，1： | 1 |
| 11 | Fourier transform spectroscopy of BaO:New ground-state constants from the A1 Σ+-X1 Σ+ chemiluminescence显示文摘 | Li H Focsa C Pinchemel B | | 0，，8： | 1 |
| 12 | Surface Passivation at Low Temperature of P-and N-type Silicon Wafers Using a Double Layer a-Si: H/SiNx: H显示文摘 | Focsa A Slaoui A Charifi H | 2009 | Materials Science and Engineering2009，159，： | 1 |
| 13 | Characterizationof laser - induced damage in silicon solar cells duringselective ablation processes 显示文摘 | Poulain G Blanc D Focsa A | 2013 | Materials Science andEngineering: B2013，178，9： | 1 |
| 14 | Selective laser doping from boron silicate glass显示文摘 | Poulain G Blanc D Focsa A | 2012 | Energy Procedia2012，，27： | 1 |
| 15 | A comparative P, aman spectroscopic study of natural gas hydrates collected at different geo logical sites显示文摘 | Chazallon B Focsa C Charlou J L | 2007 | Chemical Geology2007，244，： | 1 |
| 16 | Thin-film silicon solar cells on mullite substrates 显示文摘 | SLAOUI A PIHAN E FOCSA A | 2006 | Solar Energy Materials & Solar Cells2006，90，10： | 1 |
| 17 | Thin film polycrystalline silicon solar cells on mullite ceramlcs显示文摘 | FOCSA A GORDON I AUGER J M | 2008 | Renewable Energy2008，33，2： | 1 |
| 18 | Poly-Si films pre- pared by rapid thermal CVD on boron and phosphorus silicate glass coated ceramic substrates 显示文摘 | FOCSA A SLAOUI A PIHAN E | 2006 | Thin Solid Films2006，511，678： | 1 |
| 19 | Thin film poly- crystalline silicon solar cells on mullite ceramics显示文摘 | FOCSA A GORDON l AUGER J M | 2008 | Rene- wable Energy2008，33，2： | 1 |
| 20 | Crystallographic analysis of polysilicon films formed on foreign substrates by aluminium induced crystallisation and epitaxy显示文摘 | E. Pihan A. Focsa A. Slaoui C. Maurice | 2005 | Thin Solid Films2005，，： | 1 |
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