|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Differential regulation of JAK/STAT-signaling in patients with ulcerative colitis and Crohn’s disease显示文摘In 2018,the pan-Janus kinase(JAK)inhibitor tofacitinib was launched for the treatment of ulcerative colitis(UC).Although tofacitinib has proven efficacious in patients with active UC,it failed in patients with Crohn’s disease(CD).This finding strongly hints at a different contribution of JAK signaling in both entities.Here,we review the current knowledge on the interplay between the JAK/signal transducer and activator of transcription(STAT)pathway and inflammatory bowel diseases(IBD).In particular,we provide a detailed overview of the differences and similarities of JAK/STAT-signaling in UC and CD,highlight the impact of the JAK/STAT pathway in experimental colitis models and summarize the published evidence on JAK/STAT-signaling in immune cells of IBD as well as the genetic association between the JAK/STAT pathway and IBD.Finally,we describe novel treatment strategies targeting JAK/STAT inhibition in UC and CD and comment on the limitations and challenges of the new drug class. | Friederike Cordes Dirk Foell John Nik Ding Georg Varga Dominik Bettenworth | 2020 | World Journal of Gastroenterology2020，26，28： | 16 |
| 2 | Diagnostic utility of faecal biomarkers in patients with irritable bowel syndrome显示文摘Irritable bowel syndrome(IBS)is a common functional gastrointestinal(GI)disorder characterized by unspecific symptoms.In clinical practice it is crucial to distinguish between non-inflammatory functional problems and inflammatory,malignant or infectious diseases of the GI tract.Differentiation between these involves the use of clinical,radiological,endoscopic,histological and serological techniques,which are invasive,expensive,time-consuming and/or hindered by inaccuracies arising from subjective components.A range of faecal markers now appears to have the potential to greatly assist in the differentiation of inflammatory bowel disease(IBD)and IBS.Faecal markers of neutrophil influx into the mucosa are reliable indicators of intestinal inflammation and their role has been mainly studied in discriminating IBD from non-IBD conditions(including IBS)rather than organic from non-organic diseases.Phagocytespecific proteins of the S100 family(S100A12,calprotectin)are amongst the most promising faecal biomarkers of inflammation.Faecal leukocyte degranulation markers(lactoferrin,polymorphonuclear elastase and myeloperoxidase)have also been suggested as diagnostic tools for the differentiation of IBD and IBS.More recently,additional proteins,including granins,defensins and matrix-metalloproteases,have been discussed as differential diagnostic markers in IBD and IBS.In this review,some of the most promising faecal markers,which have the potential to differentiate IBD and IBS and to advance diagnostic practices,will be discussed. | Jan Dabritz Jason Musci Dirk Foell | 2014 | World Journal of Gastroenterology2014，20，2： | 4 |
| 3 | 建立初级卒中中心的修订和更新意见来自脑卒中联盟的总结声明显示文摘背景和目的自从2000年脑卒中联盟发布首份关于建立初级卒中中心的推荐意见以来,初级卒中中心的组建和认证工作已出现迅速发展。本文的目的在于修订和更新我们关于初级卒中中心的推荐意见以反映最新资料和经验。方法我们使用MEDLINE和PubMed数据库回顾了相关文献(2000年3月至2011年1月),主要针对急性卒中的诊断、治疗和护理。如果发现有效且相关,同样对原始文献、汇总分析和其他治疗指南进行回顾并纳入分析。标明证据等级以反映当前指南发展的实际情况。结果基于文献回顾以及针对初级卒中中心的经验,一些要素的重要性已得到进一步的加强,同时增加了几个新的领域。这些内容包括:(1)急诊卒中团队的重要性;(2)配备遥测监控的卒中单元的重要性;(3)MRj和弥散加权序列进行脑成像的实施;(4)用磁共振血管成像或CT血管成像对脑血管系统进行评价;(5)心脏影像学检查;(6)康复治疗的早期启动;(7)由独立机构进行的认证,包括实地考察和疾病评价指标。结论基于上述证据,初级卒中中心的某些要素对于改善急性卒中患者的诊治特别重要。其他要素则集中于脑、脑血管系统和心脏的影像学检查。这些新的要素也许能改善在初级卒中中心接受诊治的卒中患者的治疗和转归。 | Mark J. Alberts Richard E. Latchaw Andy Jagoda Lawrence R Wechsler Todd Crocco Mary G. George E.S. Connolly Barbara Mancini Stephen Prudhomme Daryl Gress Mary E. Jensen Robert Bass Robert Ruff Kathy Foell Rocco A. Armonda Marian Emr Margo Warren Jim Baranski Michael D. Walker 黄志超(译) 张霞(译) 尤寿江(译) 曹勇军(译) 刘春风(译) | 2012 | 国际脑血管病杂志2012，20，7： | 3 |
| 4 | CREMa overexpression decreases IL-2 production,induces a TH17 phenotype and accelerates autoimmunity显示文摘Dear Editor,External cytokines produced by cells of the innate immune system induce the dif-ferentiation of CD4+T cells into helper T cell subsets with distinct functions and cytokine profiles.Apart from TH1 and TH2 cells a third subset of helper T cells has been described,which is characterized by increased expression of IL-17A,IL-17F,IL-21 and IL-22(TH17 cells). | Ralph Lippe Kim Ohl Georg Varga Thomas Rauen Jose C.Crispin Yuang-Taung Juang Stefanie Kuerten Frank Tacke Marc Wolf Kirsten Roebrock Thomas Vogl Eva Verjans Nora Honke Jan Ehrchen Dirk Foell Boris Skryabin Norbert Wagner George C.Tsokos Johannes Roth Klaus Tenbrock | 2012 | Journal of Molecular Cell Biology2012，4，2： | 2 |
| 5 | Three-dimensional echocardiography for quantitative analysis of left-ventricular aneurysm显示文摘 | JAHNKE C FOELL D HEINRICH G | 2010 | Echocardiography2010，27，1： | 1 |
| 6 | S100 proteins expressed in phagocytes: a novel group of damage-associated molecu?lar pattern molecules显示文摘 | Foell D Wittkowski H Vogi T | 2007 | J Leukoc Bioi2007，81，1： | 1 |
| 7 | Reduction in density of transverse tubules and L-type Ca(2+) channels in canine tachycardia-induced heart failure显示文摘 | He J Conklin MW Foell JD | 2001 | Cardiovasc Res2001，49，： | 1 |
| 8 | Validation of a clinical nomo- gram to predict the successful shockwave lithotripsy of renal and ure- teral calculi 显示文摘 | Lantz AG Ghiculete D Foell K | 2013 | The Journal of urology2013，189，4： | 1 |
| 9 | Proinflammatory S100 proteinsregulate the accumulation of myeloid - derived suppressor cells显示文摘 | Sinha P Okoro C Foell D | 2008 | J Immunol2008，181，46： | 1 |
| 10 | Localization of cardiac L-type Ca2+ channels to a caveolar macromolecular signaling complex is re- quired for bcta2-adrenergic regulation 显示文摘 | Balijepalli RC Foell JD Hall DD | 2006 | Proc Natl Acad Sci USA2006，103，19： | 1 |
| 11 | Phagocyte specific calcium- binding S100 proteins as clinical laboratory markers of inflam- mation显示文摘 | Foell D Frosch M Sorg c | 2004 | Clin Chim Acta2004，344，12： | 1 |
| 12 | Early recruitment of phagocytes contributes to the vascular inflammation of giant cell arteritis显示文摘 | Foell D Hernández-Rodríguez J Sánchez M | | 0，，： | 1 |
| 13 | Myeloid related proteins MRP8/MRP14 may predict disease flares in juvenile idiopathic arthritis显示文摘 | zur Wiesch AS Foell D Frosch M | | 0，，： | 1 |
| 14 | Addressing stroke signs and symptoms through public education: the stroke heroes act FAST cam?paign显示文摘 | Foell KM Cynthia L Willis B | 2008 | Preventing Chronic Disease2008，5，2： | 1 |
| 15 | Differential expression and re- sponse to anti-TNFalpha treatment of infiltrating versus resident tis- sue macrophage subsets in autoimmune arthritis 显示文摘 | De Rycke L Baeten D Foell D | 2005 | J Pathol2005，206，1： | 1 |
| 16 | Myeloid related pro- teins MRP8/MRP14 may predict disease flares in juvenile idiopathic arthritis 显示文摘 | Schulze zur Wiesch A Foell D Frosch M | 2004 | Clin Exp Rheumato12004，22，3： | 1 |
| 17 | Expression of the pro-inflammatoty protein S100A12(EN-RAGE) in rheuma- toid and psoriatic arthritis 显示文摘 | FOELL D KANE D BRESNIHAN B | 2003 | J Rheumatology (Oxford)2003，42，11： | 1 |
| 18 | RAGE,carboxylated glycans and S100A8/A9 play essential roles in colitis associated carcinogenesis显示文摘 | Turovskaya O Foell D Sinha P | | 0，，10： | 1 |
| 19 | Potential power in the application of seismic volume attributes显示文摘 | Trappe H Hallmich G Foell M | 2000 | First Break2000，18，9： | 1 |
| 20 | Reduction in density of transverse tubules and L-type Ca^2+ channels in canine tachycardia-induced heart failure显示文摘 | He J Conklin MW Foell JD | 2001 | Cardiovasc Res2001，49，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员