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| 1 | Effective treatment of rat adjuvant-induced arthritis by celastrol显示文摘 | R. Casc?o B. Vidal H. Raquel A. Neves-Costa N. Figueiredo V. Gupta J.E. Fonseca L.F. Moita | 2012 | Autoimmunity Reviews2012，，12： | 1 |
| 2 | Paloma Lopez Garcia and Christopher A Pissarides, Entrepreneurship, Start up and Employment显示文摘 | Fonseca Raquel | 2001 | European E conomic Review2001，，45： | 1 |
| 3 | Entrepreneurship:start-upandemployment显示文摘 | Fonseca Raquel Paloma Lopez Christopher Garcia | 2001 | European Economic Review2001，45，46： | 1 |
| 4 | Dynamic mean-variance portfolio analysis under model risk显示文摘 | Kuhn Daniel Parpas Panos Rustem Ber? Fonseca Raquel | 2009 | The Journal of Computational Finance2009，，4： | 1 |
| 5 | Entrepreneurship,Start-Up and Employment 显示文摘 | Fonseca Raquel Paloma Lopez-Garcia Christopher A Pissarides | 2001 | European Eco-nomic Re vie w2001，45，： | 1 |
| 6 | Alginate Matrix of MDA-MB-231 Breast Cancer Cell 3D Culturing Alters CD44 and CD24 mRNA Levels and Induces ALDH1 Expression显示文摘 | Layane Duarte e Souza Elisa Raquel Anastacio Ferraz Isis Soares Salviano Adenilson Souza da Fonseca Israel Felzenzswalb Andre Luiz Mencalha | 2017 | Journal of Life Sciences2017，11，5： | 0 |
| 7 | Chemical composition, antiparasitic and cytotoxic activities of aqueous extracts of Ziziphus joazeiro Mart显示文摘Objective: To compare the in vitro antiparasitic activity of aqueous extracts from Ziziphus joazeiro leaves and stem bark against Trypanosoma cruzi, Leishmania braziliensis, and Leishmania infantum, as well as to evaluate its cytotoxicity in mammalian cells, in addition to identifying the chemical composition of the extracts. Methods: Ziziphus joazeiro leaf and stem bark aqueous extracts were prepared by cold extraction maceration and subjected to ultra-efficient liquid chromatography coupled to a quadrupole/time of flight system. The susceptibility assays used Trypanosoma cruzi CLB5 strains and promastigote forms of Leishmania braziliensis and Leishmania infantum for antiparasitic activity of the extracts. Moreover, mammalian fibroblasts NCTC clone 929 were used for cytotoxicity analysis. Results: Terpenoid compounds, flavonoids and phenolic acid were identified in extracts. The stem bark aqueous extracts presented more significant results in terms of antiparasitic activity compared with the leaf aqueous extracts, especially against Leishmania braziliensis and Leishmania infantum promastigote forms with an IC50 < 500 μg/mL. The cytotoxicity evaluation showed moderate toxicity of the stem bark aqueous extracts, which is relevant information for the rational use of this plant part since it is widely used by the population. Conclusions: These preliminary results may contribute to the formulation of new therapeutic agents against this group of neglected diseases, so further investigations are required to delineate the mechanisms of action mainly of the aqueous extract of stem bark of Ziziphus joazeiro. | Jacqueline Cosmo ANDrade Ana Raquel Pereira da Silva Ant?nia Thassya Lucas dos Santos Maria Audilene Freitas Yedda Maria Lobo Soares de Matos Maria Flaviana Bezerra Morais Braga Camila Fonseca Bezerra Maria Isabeli Pereira Gon?alo Maria Celeste Vega Gomez Míriam Rolóm Cathia Coronel Paulo Riceli Vasconcelos Ribeiro Edy Sousa de Brito Henrique Douglas Melo Coutinho | 2019 | Asian Pacific Journal of Tropical Biomedicine2019，9，5： | 0 |
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