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| 1 | Radiomics in colorectal cancer patients显示文摘The main therapeutic options for colorectal cancer are surgical resection and adjuvant chemotherapy in non-metastatic disease.However,the evaluation of the overall adjuvant chemotherapy benefit in patients with a high risk of recurrence is challenging.Radiological images can represent a source of data that can be analyzed by using automated computer-based techniques,working on numerical information coded within Digital Imaging and Communications in Medicine files:This image numerical analysis has been named“radiomics”.Radiomics allows the extraction of quantitative features from radiological images,mainly invisible to the naked eye,that can be further analyzed by artificial intelligence algorithms.Radiomics is expanding in oncology to either understand tumor biology or for the development of imaging biomarkers for diagnosis,staging,and prognosis,prediction of treatment response and diseases monitoring and surveillance.Several efforts have been made to develop radiomics signatures for colorectal cancer patient using computed tomography(CT)images with different aims:The preoperative prediction of lymph node metastasis,detecting BRAF and RAS gene mutations.Moreover,the use of delta-radiomics allows the analysis of variations of the radiomics parameters extracted from CT scans performed at different timepoints.Most published studies concerning radiomics and magnetic resonance imaging(MRI)mainly focused on the response of advanced tumors that under-went neoadjuvant therapy.Nodes status is the main determinant of adjuvant chemotherapy.Therefore,several radiomics model based on MRI,especially on T2-weighted images and ADC maps,for the preoperative prediction of nodes metastasis in rectal cancer has been developed.Current studies mostly focused on the applications of radiomics in positron emission tomogra-phy/CT for the prediction of survival after curative surgical resection and assessment of response following neoadjuvant chemoradiotherapy.Since colorectal liver metastases develop in about 25%of patients with colorectal carcinoma,the main diagnostic tasks of radiomics should be the detection of synchronous and metachronous lesions.Radiomics could be an additional tool in clinical setting,especially in identifying patients with high-risk disease.Nevertheless,radiomics has numerous shortcomings that make daily use extremely difficult.Further studies are needed to assess performance of radiomics in stratifying patients with high-risk disease. | Riccardo Inchingolo Cesare Maino Roberto Cannella Federica Vernuccio Francesco Cortese Michele Dezio Antonio Rosario Pisani Teresa Giandola Marco Gatti Valentina Giannini Davide Ippolito Riccardo Faletti | 2023 | World Journal of Gastroenterology2023，29，19： | 4 |
| 2 | Liver metastases:The role of magnetic resonance imaging显示文摘The liver is one of the organs most commonly involved in metastatic disease,especially due to its unique vascularization.It’s well known that liver metastases represent the most common hepatic malignant tumors.From a practical point of view,it’s of utmost importance to evaluate the presence of liver metastases when staging oncologic patients,to select the best treatment possible,and finally to predict the overall prognosis.In the past few years,imaging techniques have gained a central role in identifying liver metastases,thanks to ultrasonography,contrast-enhanced computed tomography(CT),and magnetic resonance imaging(MRI).All these techniques,especially CT and MRI,can be considered the noninvasive reference standard techniques for the assessment of liver involvement by metastases.On the other hand,the liver can be affected by different focal lesions,sometimes benign,and sometimes malignant.On these bases,radiologists should face the differential diagnosis between benign and secondary lesions to correctly allocate patients to the best management.Considering the above-mentioned principles,it’s extremely important to underline and refresh the broad spectrum of liver metastases features that can occur in everyday clinical practice.This review aims to summarize the most common imaging features of liver metastases,with a special focus on typical and atypical appearance,by using MRI. | Cesare Maino Federica Vernuccio Roberto Cannella Francesco Cortese Paolo NiccolòFranco Clara Gaetani Valentina Giannini Riccardo Inchingolo Davide Ippolito Arianna Defeudis Giulia Pilato Davide Tore Riccardo Faletti Marco Gatti | 2023 | World Journal of Gastroenterology2023，29，36： | 2 |
| 3 | Natural history of chronic HBV carriers in northern Italy: Morbidity and mortality after 30 years显示文摘 | Mauro Manno Calogero Cammà Filippo Schepis Fabio Bassi Roberta Gelmini Francesco Giannini Francesca Miselli Antonella Grottola Ilva Ferretti Chiara Vecchi Marisa De Palma Erica Villa | 2004 | Gastroenterology2004，，3： | 1 |
| 4 | Brake squeal: Linear and nonlinear numerical approaches 显示文摘 | Massi Francesco Baillet Laurent Giannini Oliviero | 2007 | Mechanical Systems and Signal Processing2007，21，： | 1 |
| 5 | Rise and fall of HCV ‐related hepatocellular carcinoma in Italy: a long‐term survey from the ITA . LI . CA centres显示文摘 | Nora Cazzagon Franco Trevisani Gemma Maddalo Anna Giacomin Veronica Vanin Caterina Pozzan Paolo Del Poggio Gianludovico Rapaccini Anna M. Di Nolfo Luisa Benvegnù Marco Zoli Franco Borzio Edoardo G. Giannini Eugenio Caturelli Maria Chiaramonte Francesco G. | 2013 | Liver Int2013，，9： | 1 |
| 6 | Natural history of chronic HBV carriers in northern Italy: Morbidity and mortality after 30 years显示文摘 | Mauro Manno Calogero Cammà Filippo Schepis Fabio Bassi Roberta Gelmini Francesco Giannini Francesca Miselli Antonella Grottola Ilva Ferretti Chiara Vecchi Marisa De Palma Erica Villa | | Gastroenterology0，，： | 1 |
| 7 | Experimental analysis of brake squeal noise on a laboratory brake setup 显示文摘 | Oliviero Giannini Adnan Akay Francesco Massi | 2006 | Journal of Sound and Vibration2006，292，12： | 1 |
| 8 | Natural history of chronic HBV carriers in northern Italy: Morbidity and mortality after 30 years显示文摘 | Mauro Manno Calogero Cammà Filippo Schepis Fabio Bassi Roberta Gelmini Francesco Giannini Francesca Miselli Antonella Grottola Ilva Ferretti Chiara Vecchi Marisa De Palma Erica Villa | 2004 | Gastroenterology2004，，3： | 1 |
| 9 | Impact of severe left ventricular dysfunction on mid-term mortality in elderly patients undergoing transcatheter aortic valve implantation显示文摘有减少的左室的功能的 BackgroundWhether 病人在大动脉的阀门培植(TAVI ) 是的 transcatheter 以后介绍更坏的结果争论。这研究的目的是估计基线的影响严重的在有大动脉的狭窄的 TAVI.MethodsSix-hundred-forty-nine 病人后面的死亡上的左室的喷射部分(LVEF ) 的缺陷与 CoreValve 系统(92.8%) 或爱德华兹智慧阀门系统(7.2%) 经历了 TAVI。基线 LVEF 被 echocardiographic Simpson 方法测量。LVEF ≤ 的影响;30% 被考克斯 regression.ResultsPatients 与 LVEF ≤ 在死亡上估计;30%(n = 63 ) ,作为与那些相比与 LVEF >30%(n = 586 ) ,有 NHYA 班 > 的更高的流行;2 (P <0.001 ) 并且与更高的 Euroscore 介绍了(P <0.001 ) 。程序的成功在两个组是类似的(98.4% 对 97.2% , P = 1 ) 。在 436 天的中部的后续以后(25 th -75 th 百分位数, 357-737 天) ,所有原因死亡[23.8% 对 23.7% , P = 0.87,危险比率(HR ) :0.96, 95% 信心间隔(CI ) :0.56-1.63 ] 并且心脏的死亡(19.1% 对 17.6% , P = 0.89, HR:1.04, 95% CI:0.57-1.90 ) 在有 LVEF ≤ 的病人是类似的;30% 作为与那些相比与 LVEF >30% 。三十天的所有原因死亡不在二个组之间是显著地不同的(11.1% 对 6.3% , P = 0.14, HR:1.81, 95% CI:0.81-4.06 ) 。有 LVEF ≤ 的病人;30% 向 30 天的心脏的死亡的更高的风险有一个趋势(11.1% 对 5.3% ;P = 0.06, HR:2.16, 95% CI:0.95-4.90 ) ,它消失在 multivariable 调整以后(P = 0.22 ).ConclusionsBaseline LVEF 的严重缺陷不是一个预言者在 TAVI 以后增加了短期、中间的死亡。有左室的功能的严重缺陷的选择病人不应该被拒绝 TAVI。 | Giuseppe Ferrante Patrizia Presbitero Paolo Pagnotta Anna Sonia Petronio Nedy Brambilla Federico De Marco Claudia Fiorina Cristina Giannini Fabrizio D'Ascenzo Silvio Klugmann Marco L Rossi Federica Ettori Francesco Bedogni Luca Testa | 2016 | Journal of Geriatric Cardiology2016，13，4： | 0 |
| 10 | Strangulated ileal trans-coloanal-anastomotic hernia:A complication of Altemeier's procedure previously never reported显示文摘A postoperative complication after Altemeier operation, so far never reported,is described in a 42 years old mentally disabled patient with external full thickness rectal prolapse who usually had prolonged straining at defecation.After 6 d from perineal rectosigmoidectomy, the patient,was discharged free of complications.Four days later he was readmitted in emergency for stran-gulated perineal trans-anastomotic ileal hernia that occurred at home during efforts to defecate.The clinical feature required an emergency operation for repositioning the ileal loops into the abdomen,resection of the necrotic ileum,and end colostomy.The outcome of the second operation was free of complication and the patient was discharged on the 6th postoperative day.In conclusion,after Altemeier operation prolonged straining at defecation should be carefully | Maria Di Lena Emanuele Angarano Ivana Giannini Altomarino Guglielmi Donato Francesco Altomare | 2013 | World Journal of Gastroenterology2013，19，5： | 0 |
| 11 | Autonomous Vehicle Platoons In Urban Road Networks:A Joint Distributed Reinforcement Learning and Model Predictive Control Approach显示文摘In this paper, platoons of autonomous vehicles operating in urban road networks are considered. From a methodological point of view, the problem of interest consists of formally characterizing vehicle state trajectory tubes by means of routing decisions complying with traffic congestion criteria. To this end, a novel distributed control architecture is conceived by taking advantage of two methodologies: deep reinforcement learning and model predictive control. On one hand, the routing decisions are obtained by using a distributed reinforcement learning algorithm that exploits available traffic data at each road junction. On the other hand, a bank of model predictive controllers is in charge of computing the more adequate control action for each involved vehicle. Such tasks are here combined into a single framework:the deep reinforcement learning output(action) is translated into a set-point to be tracked by the model predictive controller;conversely, the current vehicle position, resulting from the application of the control move, is exploited by the deep reinforcement learning unit for improving its reliability. The main novelty of the proposed solution lies in its hybrid nature: on one hand it fully exploits deep reinforcement learning capabilities for decisionmaking purposes;on the other hand, time-varying hard constraints are always satisfied during the dynamical platoon evolution imposed by the computed routing decisions. To efficiently evaluate the performance of the proposed control architecture, a co-design procedure, involving the SUMO and MATLAB platforms, is implemented so that complex operating environments can be used, and the information coming from road maps(links,junctions, obstacles, semaphores, etc.) and vehicle state trajectories can be shared and exchanged. Finally by considering as operating scenario a real entire city block and a platoon of eleven vehicles described by double-integrator models, several simulations have been performed with the aim to put in light the main f eatures of the proposed approach. Moreover, it is important to underline that in different operating scenarios the proposed reinforcement learning scheme is capable of significantly reducing traffic congestion phenomena when compared with well-reputed competitors. | Luigi D’Alfonso Francesco Giannini Giuseppe Franzè Giuseppe Fedele Francesco Pupo Giancarlo Fortino | 2024 | IEEE/CAA Journal of Automatica Sinica2024，11，1： | 0 |
| 12 | Albumin-bilirubin score in non-malignant liver diseases should be properly validated显示文摘The albumin-bilirubin(ALBI)score to assess the risk of decompensation in patients with initially compensated cirrhosis may improve their prognostic evaluation.This letter critically evaluates the research,which utilizes the ALBI score to forecast decompensation in cirrhosis patients over a three-year period.This score was initially developed to assess liver function in hepatocellular carcinoma,its prognostic utility for non-malignant liver diseases has now been explored,recognizing decompensation as a pivotal event that significantly affects patient’s survival.Some concerns regarding the methodology of this research may be raised,particularly the exclusive use of radiological diagnosis,potentially including patients without definite cirrhosis and thus skewing the decompensation risk assessment.The reported predominance of variceal bleeding as a decompensating event conflicts with established literature,that often reports ascites as the initial decompensation manifestation.The letter highlights the absence of details on esophageal varices and their management,which could introduce bias in evaluating the ALBI score's predictive power.Furthermore,the letter points out the small sample size of patients with high-risk ALBI grades,potentially compromising the score's validity in this context.We suggest prospective future research to investigate the dynamic changes in the ALBI score over time to reinforce the validity of the ALBI score as a predictor of decompensation in non-malignant liver disease. | Andrea Pasta Francesco Calabrese Maria Corina Plaz Torres Giorgia Bodini Manuele Furnari EdoardoVincenzo Savarino Vincenzo Savarino Edoardo Giovanni Giannini Elisa Marabotto | 2023 | World Journal of Gastroenterology2023，29，46： | 0 |
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