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| 1 | Adiponectin affects the mechanical responses in strips from the mouse gastric fundus显示文摘AIM To investigate whether the adipocytes derived hormone adiponectin(ADPN) affects the mechanical responses in strips from the mouse gastric fundus. METHODS For functional experiments, gastric strips from the fundal region were cut in the direction of the longitudinal muscle layer and placed in organ baths containing KrebsHenseleit solution. Mechanical responses were recorded via force-displacement transducers, which were coupled to a polygraph for continuous recording of isometric tension. Electrical field stimulation(EFS) was applied via two platinum wire rings through which the preparation was threaded. The effects of ADPN were investigated on the neurally-induced contractile and relaxant responses elicited by EFS. The expression of ADPN receptors, Adipo-R1 and Adipo-R2, was also evaluated by touchdown-PCR analysis. RESULTS In the functional experiments, EFS(4-16 Hz) elicited tetrodotoxin(TTX)-sensitive contractile responses. Addition of ADPN to the bath medium caused a reduction in amplitude of the neurally-induced contractile responses(P < 0.05). The effects of ADPN were no longer observed in the presence of the nitric oxide(NO) synthesis inhibitor L-NG-nitro arginine(L-NNA)(P > 0.05). The direct smooth muscle response to methacholine was not influenced by ADPN(P > 0.05). In carbachol precontracted strips and in the presence of guanethidine, EFS induced relaxant responses. Addition of ADPN to the bath medium, other than causing a slight and progressive decay of the basal tension, increased the amplitude of the neurally-induced relaxant responses(P < 0.05). Touchdown-PCR analysis revealed the expression of both Adipo-R1 and Adipo-R2 in the gastric fundus.CONCLUSION The results indicate for the first time that ADPN is able to influence the mechanical responses in strips from the mouse gastric fundus. | Eglantina Idrizaj Rachele Garella Giovanni Castellini Hermine Mohr Natalia S Pellegata Fabio Francini Valdo Ricca Roberta Squecco Maria Caterina Baccari | 2018 | World Journal of Gastroenterology2018，24，35： | 2 |
| 2 | CEA and CA19.9 as Early Predictors of Progression in Advanced/Metastatic Colorectal Cancer Patients Receiving Oxaliplatin-Based Chemotherapy and Bevacizumab显示文摘 | Roberto Petrioli Antonella Licchetta Giandomenico Roviello Alessandra Pascucci Edoardo Francini Gianluca Bargagli Raffaele Conca Salvatora Tindara Miano Giuseppe Marzocca Guido Francini Multidisciplinary Oncology Group on Gastrointestinal Tumors | 2012 | Cancer Investigation2012，，1： | 2 |
| 3 | Skeletal myoblasts overexpressing relaxin improve differentiation and communication of primary mu- rine cardiomyoeyte cell cultures 显示文摘 | Formigli L Francini F Nistri S | 2009 | J Mol Cell Cardiol2009，47，2： | 1 |
| 4 | Placebo of trimetazidine ( 99 m) Tc Tetrofosm in myocardial SPECT and low-dose dobutamine echo- cardingraphy in liberating myocardium 显示文摘 | Feola M Biggi A Francini A | 2006 | Arch Med Res2006，37，1： | 1 |
| 5 | Exemestane after tamoxifen as adjuvant hormonal therapy in postmenopausal women with breast cancer: effects on body composition and lipids显示文摘 | FRANCINI G PETRIOLI R MONTAGNANI A | 2006 | Br J Cancer2006，17，2： | 1 |
| 6 | Morphofunctional integration between skeletal myoblasts and adult cardiomyocytes in cocuhure is favored by directcell-cell contacts and relaxin treatment 显示文摘 | Formigli L Francini F Tani A | 2005 | Am J Physiol Cell Physiol2005，288，4： | 1 |
| 7 | Solar system for exploitation of the whole collected energy显示文摘 | Ciamberlini C Francini F Longobardi G | 2003 | Optics and Lasers in Engineering2003，39，2： | 1 |
| 8 | Relaxin favors the morphofunctional integration between skeletal myoblasts and adult cardiomyocytes in coculture显示文摘 | Formigli L Francini F Chiappini L | 2005 | Ann NY Acad Sci2005，1041，： | 1 |
| 9 | Morphofunctional integration between skeletal myoblasts and adult cardiomyocytes in coculture is favored by direct cell-cell contacts and relaxin treatment显示文摘 | Formigli L Francini F Tani A | 2005 | Am J Physiol Cell Physiol2005，288，4： | 1 |
| 10 | Skeletal myoblasts overexpressing relaxin improve differentiation and communication of primary murine cardiomyocyte cell cultures 显示文摘 | Formigli L Francini F Nistri S | 2009 | J nol Cell Cardiol2009，47，2： | 1 |
| 11 | Phylogenetic relationships of butterflies of the tribe Acraeini (Lepidoptera, Nymphalidae, Heliconiinae) and the evolution of host plant use 显示文摘 | SILVA -BRANDAO K L WAHLBERG N FRANCINI R B | 2008 | Molecular Phylogeneties and Evolution2008，46，2： | 1 |
| 12 | Glycyrrhetinic acid, the active principle of licorice, can reduce the thickness of subcuta- neous thigh fat through topical application 显示文摘 | Armanini D Nacamulli D Francini P F | 2005 | Steroids2005，70，： | 1 |
| 13 | Glycyrrhetinic acid, the active principle of licorice, can reduce the thickness of subcutaneous thigh fat through topical application显示文摘 | Armanini D Nacamulli D Francini P F | 2005 | Steroids2005，70，： | 1 |
| 14 | Weekly docetaxel and epirubicin in treatment of advanced hormone-refractory prostate cancer显示文摘 | Petrioli R Paolelli L Francini E | 2007 | Urology2007，69，1： | 1 |
| 15 | Evaluating Fluorinated Acrylic Latices as Textile Water and Oil Repellent Finishes 显示文摘 | CASTELVETRO V FRANCINI G | 2001 | Text Res J2001，71，5： | 1 |
| 16 | On-line textile quality control using optical Fourier transforms 显示文摘 | Casterllini C Francini F Longobardi G | 1996 | Optics and Lasers in Engineering1996，24，： | 1 |
| 17 | The role of doxorubicin and epimbiein in the treatment of patients with metastatic hormonerefract- ory prostate cancer显示文摘 | Petrioli R Fiaschi A Francini E | 2008 | Cancer Treat Rev2008，34，： | 1 |
| 18 | Sequential treatment with epirubi- cin, oxaliplatin and 5 FU (EOF) followed by docetaxel, oxaliplatin and 5FU(DOF) in patients with advanced gastric or gastroesophageal cancer: a single - institution experience 显示文摘 | Petrioli R Francini E Roviello F | 2015 | Cancer Chemother Phar- maco12015，75，5： | 1 |
| 19 | A new experimental protocol for preferential differentiation of mouse embryonic stem cells into insulin-producing cells 显示文摘 | Naujok O Francini F Picton S | 2008 | Cell Transplant2008，17，1011： | 1 |
| 20 | Skeletal myoblasts overexpressing relaxin improve differentiation and communi-cation of primary murine cardiomyocyte cell cultures显示文摘 | Formigli L Francini F Nistri S | | 0，，02： | 1 |
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