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| 1 | Clinical outcomes of endoscopic management of pancreatic fluid collections in cirrhotics vs non-cirrhotics: A comparative study显示文摘BACKGROUND Endoscopic management of symptomatic pancreatic fluid collections (PFCs) using self-expandable metal stents (SEMS) placement has emerged as an innovative therapeutic approach with excellent efficacy, safety, and relatively few adverse outcomes. However, their use has not been studied in patients with cirrhosis. Cirrhotics tend to be considered less than optimal candidates due to concern for portal hypertension and coagulopathy related complications. AIM To compare the efficacy and safety of using SEMS for drainage of symptomatic PFCs in cirrhotic vs non-cirrhotic patients. METHODS We conducted a retrospective comparative analysis of patients with symptomatic PFCs [pancreatic pseudocyst (PP) or walled-off necrosis (WON)] who underwent endoscopic ultrasound (EUS)-guided placement of fully covered self-expandable metals stents or lumen-apposing self-expandable metal stents. All patients were followed clinically until resolution of PFCs or death. Definition:(1) Technical success was defined as successful placement of SEMS;and (2) Clinical success was defined as complete resolution of the PFCs without additional interventions including interventional radiology or surgery. Number of procedures performed per patient, number of patients who achieved complete resolution of the PFCs without additional interventions and procedure related adverse events were recorded.RESULTS From January 2012 to December 2017, a total of 88 patients underwent EUSguided drainage of symptomatic PFCs. Of these, 58 non cirrhotic patients underwent plastic stent insertion for management of PFC and 30 patients, 5 with cirrhosis and 25 without cirrhosis, underwent EUS-guided transmural drainage with SEMS, including 18 (60%) PP and 12 (40%) WON. Technical success was achieved in all 30 patients. Clinical success was achieved in 60% cirrhotic patients and 92% non-cirrhotics (P = 0.12). Procedure-related adverse events were 60% in cirrhotic and 28% non-cirrhotic (P = 0.62). Moreover, fatal adverse events were statistically more common in cirrhotics compared with non-cirrhotics (0 vs 40%;P = 0.023). Successful stent removal following resolution of the PFC, was 60% in cirrhotics and 80% in non-cirrhotics (P = 0.57). Post-procedure length of hospitalization was 18.6 ± 20.3 d in cirrhotics and 5.6 ± 13.7 d in non-cirrhotics (P = 0.084). CONCLUSION EUS-guided management of PFC using SEMS placement has a high technical and clinical success rate in non-cirrhotics. However, in cirrhotics caution must be exercised given the high morbidity and mortality as evidenced by our cohort, particularly for the endoscopic debridement of WONs. Larger, multicenter studies are warranted to further characterize the risk profile and outcomes in these patients. | Sobia Laique Matheus C Franco Tyler Stevens Amit Bhatt John J Vargo Prabhleen Chahal | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，6： | 2 |
| 2 | Ozone interaction with conjugated polymer-Ⅱ polyphenylacetylene显示文摘 | FRANCO C J | 1998 | Polymer Degradation and Stability1998，60，： | 1 |
| 3 | Geostatistical modelling of heavy metal contamination in the topsoil of Guadiamar river margins ( S Spain) using a stochastic simulation technique 显示文摘 | Franco C Soares A Delgado J | 2006 | Geoderma2006，136，34： | 1 |
| 4 | Effectsof glycosylation on heparin binding and antithromhin activation by hep-arin显示文摘 | Pol-Fachin L Franco Becker C Almeida Guimaraes J | 2011 | Proteins2011，79，9： | 1 |
| 5 | Viscosity measurement of newtonian liquids using the complex reflec- tion coefficient显示文摘 | Franco E E Adamowski J C Higuti R T | 2008 | IEEE Transactions on Ultrasonic Ferro- electrics and Frequency Control2008，55，10： | 1 |
| 6 | Sap flow and stomatal conductance in two evergreen woody species in an open savanna and a savanna woodland显示文摘 | Naves - Barbiero C C Franco A C Bucci S J | 2000 | Revista Brasileira de Fisiologia Vegetal2000，12，2： | 1 |
| 7 | Baseline of butyltin pollution in coastal sediments within the Basque Country (northern Spain), in 2007-2008显示文摘 | Rodriguez J G~ Solaun O Larreta J Segarra M J B Franco J Alonso J I G Sariego C Valencia V Borja A | 2010 | Marine Pollution Bulletin2010，60，1： | 1 |
| 8 | The association of mafic-ultramafic intrusions and A-type magmatism in the Tian Shan and Altay orogens, NW China: Implica- tions for geodynamic evolution and potential for the dis- covery of new ore deposits显示文摘 | Franco P J Mao J W Zhang Z C | 2008 | Journal of Asian Earth Sciences2008，32，2： | 1 |
| 9 | Impacts of climate warming and habitat loss on extinctions at species' low lati tude range boundaries显示文摘 | Franco A M A Hill J K Kitschke C | 2006 | Global Change Biology2006，12，： | 1 |
| 10 | Ultrasonic viscosity measure- ment using the shear-wave reflection coefficient with a novel signal processing technique 显示文摘 | Franco E E Adamowski J C | 2010 | IEEE Transactions on Ul- trasonics Ferroelectrics and Frequency Control2010，57，5： | 1 |
| 11 | Visualization of an endophytic Streptomyces species in wheat seed 显示文摘 | Coombs J T Franco C M M | 2003 | Applied and Environmental Microbiology2003，69，7： | 1 |
| 12 | Transmission loss allocation through equivalent bilateral exchanges and economical analysis显示文摘 | MATEUS J C FRANCO P C | 2005 | IEEE Trans on Power Systems2005，20，4： | 1 |
| 13 | Isolation and identification of actinobaeteria from surface - sterilized wheat roots 显示文摘 | Coombs J T Franco C M M | 2003 | Appl Environ Microbiol2003，69，9： | 1 |
| 14 | Pyrolysis applied to the study of a Maya asphaltene显示文摘 | DOUDA J LLANOS M E ALVAREZ R FRANCO C L de la FUENTE J A M | 2004 | J Anal Appl Pyrolysis2004，71，2： | 1 |
| 15 | Influence of molecular weight and free NCO content on the rheologicalproperties of lithium lubricating greases modified with NCO - terminated pre- polymers显示文摘 | Moreno G Valencia C Franco J M | 2008 | European Polymer Journal2008，，44： | 1 |
| 16 | Xenon purity analysis for exo-200 via mass spectrometry 显示文摘 | Dobi A Hall C Slutsky S Yen Y R Aharmin B Auger M Barbeau P S Benitez-Medina C Breidenbach M Cleveland B Conley R Cook J Cook S Counts I Craddock W Daniels T Davis C G Davis J Devoe R Dixit M Dolinski M J Donato K Fairbank Jr W Farine J Fierlinger P Franco D Giroux G Gornea R Graham K Gratta G Green C Hagemann C Hall K Hallman D Hargrove C Herrin S Hughes M Hodgson J Juget F Karelin A Kaufman L J Kuchenkov A Kumar K Leonard D S Lutter G Mackay D Maclellan R Marino M Mong B Montero Diez M Morgan P MUller A R Neilson R Odian A Oullivan K Piepke A Pocar A Prescott C Y Pushkin K Rivas A Rollin E Rowson P C Sabourov A Sinclair D Skarpaas K Stekhanov V Strickland V Swift M Twelker K Vuilleumier J L Vuilleumier J M Weber M Wichoski U Wodin J Wright J D Yang L | 2012 | Nuclear Instruments and Methods in Physics Research Section A: Accelerators Spectrometers Detectors and Associated Equipment2012，675，： | 1 |
| 17 | Effect of calcium and calcium minerals in coal on its thermal analysis显示文摘 | MAES I I GRYGLEWICZ G YPERMAN J FRANCO D V MULLENS J VAN POUCKE L C | 1997 | Fuel1997，76，2： | 1 |
| 18 | Optical and mag- netic characterization of pure and vanadium-doped Bi12TiO20 sillenite crystals 显示文摘 | CARVALHO J F FRANCO R W A MAGON C J | 1999 | Opt Mater1999，13，： | 1 |
| 19 | Sulphur group analysis in solid matrices by atmospheric pressure-temperature programmed reduction显示文摘 | YPERMAN J MAES I I VAN DEN RUL H MULLENS S VAN AELST J FRANCO D V MULLENS J VAN POUCKE L C | 1999 | Anal Chim Acta1999，395，12： | 1 |
| 20 | Factors that affect the enzymatic degradation of natural starch granules - effect of the size of the granules显示文摘 | Franco C M L Preto S J R Ciacco C F | 1992 | Starch1992，44，11： | 1 |
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