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| 1 | 螺内酯与可乐定作为难治性高血压第4种治疗药物的比较:难治性高血压的最佳治疗随机研究显示文摘该研究旨在通过一个多中心随机试验对作为难治性高血压患者的第4种治疗药物的螺内酯与可乐定进行比较。采用药丸计数评估药物治疗依从性。难治性高血压患者(定义为包括1种利尿剂在内的3种药物治疗12周,诊室及动态血压监测血压仍未控制)随机给予螺内酯(12.5~50 mg/d)或可乐定(0.1~0.3mg,2次/d)继续治疗12周。 | Krieger EM Drager LF Giorgi DMA Pereira AC Barreto-Filho JAS Nogueira AR Mill JG Lotufo PA Amodeo C Batista MC Bodanese LC Carvalho ACC Castro I Chaves H Costa EAS Feitosa GS Franco RJS Fuchs FD Guimarāes AC Jardim PC Machado CA Magalhāes ME Mion D Jr Nascimento RM Nobre F Nóbrega AC Ribeiro ALP Rodrigues-Sobrinho CR Sanjuliani AF Teixeira MDCB Krieger JE ReHOT Investigators 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，3： | 7 |
| 2 | Clinical outcomes of endoscopic management of pancreatic fluid collections in cirrhotics vs non-cirrhotics: A comparative study显示文摘BACKGROUND Endoscopic management of symptomatic pancreatic fluid collections (PFCs) using self-expandable metal stents (SEMS) placement has emerged as an innovative therapeutic approach with excellent efficacy, safety, and relatively few adverse outcomes. However, their use has not been studied in patients with cirrhosis. Cirrhotics tend to be considered less than optimal candidates due to concern for portal hypertension and coagulopathy related complications. AIM To compare the efficacy and safety of using SEMS for drainage of symptomatic PFCs in cirrhotic vs non-cirrhotic patients. METHODS We conducted a retrospective comparative analysis of patients with symptomatic PFCs [pancreatic pseudocyst (PP) or walled-off necrosis (WON)] who underwent endoscopic ultrasound (EUS)-guided placement of fully covered self-expandable metals stents or lumen-apposing self-expandable metal stents. All patients were followed clinically until resolution of PFCs or death. Definition:(1) Technical success was defined as successful placement of SEMS;and (2) Clinical success was defined as complete resolution of the PFCs without additional interventions including interventional radiology or surgery. Number of procedures performed per patient, number of patients who achieved complete resolution of the PFCs without additional interventions and procedure related adverse events were recorded.RESULTS From January 2012 to December 2017, a total of 88 patients underwent EUSguided drainage of symptomatic PFCs. Of these, 58 non cirrhotic patients underwent plastic stent insertion for management of PFC and 30 patients, 5 with cirrhosis and 25 without cirrhosis, underwent EUS-guided transmural drainage with SEMS, including 18 (60%) PP and 12 (40%) WON. Technical success was achieved in all 30 patients. Clinical success was achieved in 60% cirrhotic patients and 92% non-cirrhotics (P = 0.12). Procedure-related adverse events were 60% in cirrhotic and 28% non-cirrhotic (P = 0.62). Moreover, fatal adverse events were statistically more common in cirrhotics compared with non-cirrhotics (0 vs 40%;P = 0.023). Successful stent removal following resolution of the PFC, was 60% in cirrhotics and 80% in non-cirrhotics (P = 0.57). Post-procedure length of hospitalization was 18.6 ± 20.3 d in cirrhotics and 5.6 ± 13.7 d in non-cirrhotics (P = 0.084). CONCLUSION EUS-guided management of PFC using SEMS placement has a high technical and clinical success rate in non-cirrhotics. However, in cirrhotics caution must be exercised given the high morbidity and mortality as evidenced by our cohort, particularly for the endoscopic debridement of WONs. Larger, multicenter studies are warranted to further characterize the risk profile and outcomes in these patients. | Sobia Laique Matheus C Franco Tyler Stevens Amit Bhatt John J Vargo Prabhleen Chahal | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，6： | 2 |
| 3 | Bipolar transurethral resection of prostate: clinical and urodynamic evaluation显示文摘 | Iori F Franco G Leonardo C Laurenti C Tubaro A D-Amico F | 2008 | Urology2008，71，： | 1 |
| 4 | Efficacy of a bivalent L1 virus-like particle vaccine in prevention of infection with human papillomavirus types 16 and 18 in young women: a randomised controlled trial 显示文摘 | Harper DM Franco EL Wheeler C | 2004 | Lancet2004，364，9447： | 1 |
| 5 | High incidence of benign testicular neoplasms diagnosed by ultrasound显示文摘 | Luca C Franco G Giacomo G | 2003 | J Urol2003，170，5： | 1 |
| 6 | Bipolar transurethral resection of prostate: clinical and urodynamic evaluation 显示文摘 | IORI F FRANCO G LEONARDO C | 2008 | Urology2008，71，2： | 1 |
| 7 | Ozone interaction with conjugated polymer-Ⅱ polyphenylacetylene显示文摘 | FRANCO C J | 1998 | Polymer Degradation and Stability1998，60，： | 1 |
| 8 | PCNA in the testis of the frog, Rana esculenta; A molecular marker of the mitotic testicular epithelium proliferation显示文摘 | Paolo C Franco R Fulgione D | 2000 | General and Comparative Endocrinology2000，119，： | 1 |
| 9 | The study of reactions influencing the biomass steam gasification gasification process 显示文摘 | Franco C Pinto F Gulyurtlu I | 2003 | Fuel2003，，7： | 1 |
| 10 | 3,5-Dimethylphenylcar- barnates of amylose, chitosan and cellulose bonded on silica gel Com- parison of their chiral recognition abilities as high-performance liquid chromatography chiral stationary phases显示文摘 | Franco P Senso A Minguillo'na C | 1998 | J Chromatography A1998，，： | 1 |
| 11 | Simple and sensitive high-performance liquid chromatography fluorescence method for the determination of citrinin-application to the analysis of fungal cultures and cheese extracts显示文摘 | FRANCO C M FENTE C A VAZQUEZ B | 1996 | Journal of Chromatography1996，723，： | 1 |
| 12 | Geostatistical modelling of heavy metal contamination in the topsoil of Guadiamar river margins ( S Spain) using a stochastic simulation technique 显示文摘 | Franco C Soares A Delgado J | 2006 | Geoderma2006，136，34： | 1 |
| 13 | Effectsof glycosylation on heparin binding and antithromhin activation by hep-arin显示文摘 | Pol-Fachin L Franco Becker C Almeida Guimaraes J | 2011 | Proteins2011，79，9： | 1 |
| 14 | Structure of NiCrAlY coatings deposited on single-crystal alloy turbine blade material by laser cladding 显示文摘 | VILAR R SANTOS E C FERREIRA P N FRANCO N DA SILVA | 2009 | Acta Materialia2009，57，18： | 1 |
| 15 | Efficacy of a bivalent L1 virus-like particle vaccine in prevention of infection with human papillomavirus types 16 and 18 in young women: a randomised controlled trial显示文摘 | Harper DM Franco EL Wheeler C | 2004 | Lancet2004，364，9447： | 1 |
| 16 | Viscosity measurement of newtonian liquids using the complex reflec- tion coefficient显示文摘 | Franco E E Adamowski J C Higuti R T | 2008 | IEEE Transactions on Ultrasonic Ferro- electrics and Frequency Control2008，55，10： | 1 |
| 17 | Overtopping formulas for caisson breakwaters with nonbreaking 3 D waves 显示文摘 | Franco C Franco L | 1999 | Journal of Waterway Port Coastal and Ocean Engineering1999，125，2： | 1 |
| 18 | Efficacy of a bivalent L1 virus-like particle vaccine in prevention of infection with human papillomavirus types 16 and 18 in young women :a randomised controlled trial 显示文摘 | Harper DM Franco EL Wheeler C | 2004 | Lancet2004，364，9447： | 1 |
| 19 | Medley GF (2004) The reinfection threshold promotes variability in tuberculosis epidemiology and vaccine efficacy显示文摘 | Gomes M G Franco A O Gomes M C | 2004 | Proceedings of the Royal Society B Biological Sciences2004，271，： | 1 |
| 20 | Factors that affect the enzymatic degradation of natural starch granules effect of the size of the granules显示文摘 | Franco C M L Ciacco C F | 1992 | Starch1992，44，11： | 1 |
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