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| 1 | 精液分析和精子功能测试显示文摘尽管对于精液分析的临床应用价值仍存在争议,但男性生育能力的调查研究仍有赖于标准化的精液参数分析。这一现状在发展中国家和发达国家的不育诊所中尤其常见,其它可选择的检测和更复杂高级的技术还未被广泛应用。这篇综述着重强调了世界卫生组织新的精液分析手册中描述的精液分析方面的重要调整。手册中提到的最重要的变化是,以循证医学为基础的出版物作为参考来确定常态值的临界值。除了上述的变化,初步评估及操作方法在大多数情况下与之前的版本相同。此外,本文评估了男科学质量控制的重要性,强调了对精子形态的评价。rygerberg医院自1995年开始启动了世界卫生组织精子形态学培训计划。外部质量控制计划已经确保了绝大多数参与者已经具有了精子形态判断技能。本文进一步综合了当前的精子功能试验,如诱导顶体反应,精子一透明带结合试验,以及对精子质量的影响(DNA完整性),和精子功能检测与精子形态的关系。 | Daniel R Franken Sergio Oehninger | 2012 | Asian Journal of Andrology2012，14，1： | 11 |
| 2 | A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling显示文摘The stromal compartment of the tumor microenvironment consists of a heterogeneous set of tissue-resident and tumor-infiltrating cells,which are profoundly moulded by cancer cells.An outstanding question is to what extent this heterogeneity is similar between cancers affecting different organs.Here,we profile 233,591 single cells from patients with lung,colorectal,ovary and breast cancer(n=36)and construct a pan-cancer blueprint of stromal cell heterogeneity using different single-cell RNA and protein-based technologies.We identify 68 stromal cell populations,of which 46 are shared between cancer types and 22 are unique.We also characterise each population phenotypically by highlighting its marker genes,transcription factors,metabolic activities and tissue-specific expression differences.Resident cell types are characterised by substantial tissue specificity,while tumor-infiltrating cell types are largely shared across cancer types.Finally,by applying the blueprint to melanoma tumors treated with checkpoint immunotherapy and identifying a naive CD4+T-cell phenotype predictive of response to checkpoint immunotherapy,we illustrate how it can serve as a guide to interpret scRNA-seq data.In conclusion,by providing a comprehensive blueprint through an interactive web server,we generate the first panoramic view on the shared complexity of stromal cells in different cancers. | Junbin Qian Siel Olbrecht Bram Boeckx Hanne Vos Damya Laoui Emre Etlioglu Els Wauters Valentina Pomella Sara Verbandt Pieter Busschaert Ayse Bassez Amelie Franken Marlies Vanden Bempt Jieyi Xiong Birgit Weynand Yannick van Herck Asier Antoranz Francesca Maria Bosisio Bernard Thienpont Giuseppe Floris Ignace Vergote Ann Smeets Sabine Tejpar Diether Lambrechts | 2020 | Cell Research2020，30，9： | 11 |
| 3 | Atrial fibrillation in the elderly显示文摘这评论根据心脏的心律不齐的巴西社会的指南和巴西 Cardiogeriatrics 指南讨论 atrial 纤维性颤动。我们强调 atrial 纤维性颤动的 thromboembolic 负担并且讨论怎么象进行 atrial fibrillatios 的盒子在的最好的方法一样阻止它老,回复心律不齐到湾穴节奏,或心率控制的选择。对待 atrial 纤维性颤动的新方法例如 radiofrequency 脱离,新口头的直接凝血酵素禁止者和 Xa 因素禁止者,以及新 antiarrhythmic 药,被描绘。 | Roberto A. Franken Ronaldo F. Rosa Silvio CM Santos | 2012 | Journal of Geriatric Cardiology2012，9，2： | 5 |
| 4 | Human disturbance of B ewick’s S wans is reflected in giving‐up net energy intake rate, but not in giving‐up food density显示文摘 | Abel Gyimesi Marycha S. Franken Nicole Feige Bart A. Nolet | 2012 | Ibis2012，，： | 3 |
| 5 | Vagueness and approximation in relevance theory显示文摘 | Nathalie Franken | 1997 | Journal of Pragmatics1997，，2： | 2 |
| 6 | Approximate image-based tree-modeling using particle flows显示文摘 | Boris Neubert Thomas Franken Oliver Deussen | 2007 | ACM Transactions on Graphics (TOG)2007，，3： | 2 |
| 7 | Optical harmonics and nonlinear phenomena显示文摘 | Ward J F | 1963 | Rev Mod Phys1963，35，： | 1 |
| 8 | Sperm chromatin packaging as an indicator of in-vitro fertilization rates显示文摘 | Esterhuizen AD Franken DR Lourens JGH | 2000 | Hum Reprod2000，15，3： | 1 |
| 9 | Sex determination in the Monoecious Species cucumber is confined to specific floral whorls显示文摘 | Kartin M Kater John Franken Kim J Carney | 2001 | The Plant Cell2001，13，： | 1 |
| 10 | The Petunia MADS box gene FBPll determines ovule identity显示文摘 | Colombo L Franken J Koetje E | 1995 | Plant Cell1995，7，11： | 1 |
| 11 | Tumour-stroma interactions in colorectal cancer:converging on betacatenin activation and cancer stemness显示文摘 | LE N H FRANKEN P FODDER | 2008 | Br J Cancer2008，98，12： | 1 |
| 12 | Inhibition of extracellular signal-regulated kinase (ERK) activity with SL327 does not prevent acquisition, expression, and extinction of ethanol-seeking behavior in mice 显示文摘 | Groblewski PA Franken FH Cunningham CL | 2011 | Behav Brain Res2011，217，2： | 1 |
| 13 | Head injury from bicycle accidents显示文摘 | Josef Zentner Heike Franken Gregor Lohbecke | 1996 | Clinic Neurology and neurosurgery1996，98，： | 1 |
| 14 | LysM domain receptor kinases regulating rhizobial Nod factor- induced infection 显示文摘 | Limpens E Franken C Smit P | 2003 | Science2003，302，： | 1 |
| 15 | Acrosomal morphology as a novel criterion for male fertility diagnosis:relation with acrosin activity,morphology(strict criteria),and fertilization in vitro显示文摘 | Menkveld R Rhemrev JP Franken DR | 1996 | Fertil Steril1996，65，3： | 1 |
| 16 | Predictive value for pro- gression to tuberculosis by igra and tst in immigrant contacts显示文摘 | Kik SV Franken WP Mensen M | 2010 | Eur Respir J2010，35，6： | 1 |
| 17 | Use of thefluorescent timer DsRed-E5 as reporter to monitor dynamics ofgene activity in plants 显示文摘 | Mirabella R Franken C van der Krogt G N ef al | 2004 | Plant Physiol2004，135，4： | 1 |
| 18 | Identifica-tion of major epitopes of Mycobacterium tuberculosis AG85B that are recognized by HLA-A * 0201-restricted CD8+ T cells in HLA-transgenic mice and humans显示文摘 | Geluk A van Meijgaarden KE Franken KL | 2000 | J Immunol2000，165，11： | 1 |
| 19 | Doppler myocardial ima-ging in the diagnosis of early systolic left ventricular dysfunction in diabetic rats显示文摘 | Weytjens C Franken PR D'hooge J | | 0，，03： | 1 |
| 20 | Crystal structure of haloalkane dehalogenase: an enzyme to detoxify halogenated alkanes 显示文摘 | Franken SM Rozeboom HJ Kalk KH Dijkstra BW | 1991 | EMBO J1991，10，： | 1 |
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