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1203例农村有偿献血感染HIV患者抑郁障碍及生活质量调查显示文摘目的:调查通过献血途径感染人类免疫缺陷病毒(HIV)的203例患者的情绪状况及生活质量。方法:采用贝克抑郁问卷、复合性国际诊断用检查提纲和SF-36对203例通过献血途径感染HIV的患者(HIV阳性组)及年龄、性别和受教育年限相匹配的198例HIV阴性献血者进行调查。结果:①HIV阳性组献血次数多于HIV阴性组(52.2±95.4/13.2±23.9,P<0.001),已婚者少于HIV阴性组(88.6%/ 95.5%,P=0.020),丧偶者多于HIV阴性组(10.9%/4.5%,P=0.020),失业率高于HIV阴性组(21.7%/4.0%,P<0.001),前一年全年工作时间少于HIV阴性组(5.0±3.5/7.5±3.0,P<0.001),家庭月收入低于HIV阴性组(476.3±412.7/709.9±513.7,P<0.001)。②HIV阳性组被诊断为获得性免疫缺陷综合征(AIDS)者占56.6%。HIV阳性组抑郁症的终生患病率为13.8%,HIV阴性组的终生患病率为5.1%。HIV阳性组的抑郁总分(11.3±11.3/6.6±9.6)、躯体(3.3±2.9/2.0±2.6)和非躯体因子分(8.0±8.8/4.6±7.4)均高于HIV阴性组(P<0.001)。HIV阳性组达轻度抑郁以上者占40.4%。HIV阳性组已制定自杀计划者高于HIV阴性组(8.4%/3.0%,P<0.05)。HIV阳性组总体生理健康(48.3±9.7/ 55.5±7.0)和心理健康(48.8±8.9/55.1±7.8)得分均低于HIV阴性组(P<0.001)。③HIV阳性组的贝克抑郁问卷总分与T细胞亚群CD4细胞计数无显著相关,与总体生理健康及心理健康呈显著负相关(r=- 0.46~0.68,P<0.001)。结论:HIV阳性患者生存状况较差。对HIV阳性感染者而言,抑郁给患者生活质量造成全面的影响,抑郁和自杀风险仍然是需要干预和处理的问题。宁南义 石川 于欣 陈玉芳 吴尊友 Jin Hua Vigil O Cysique LA Franklin DR Grant I Heaton RK 2008中国心理卫生杂志2008,22,7:14
2HIV-associatedneurocognitive disorders before and during the era ofcombination antiretroviral therapy: differences in rates,nature, and predictors 显示文摘Heaton RK Franklin DR Ellis RJ 2011J Neurovirol2011,17,1:1
3Environment, disturbance history and rain forest composition across the islands of Ton- ga, Western Polynesia显示文摘Franklin J Wiser SK Drake DR Burrows LE Sykes WR 2006J Veget Sci2006,17,2:1
4HIV-associated neu- rocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors 显示文摘Heaton RK Franklin DR Ellis R J 2011J Neurovirol2011,17,:1
5HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors 显示文摘Heaton RK Franklin DR Ellis R J 2011J Neurovirol2011,17,:1
6HIV-associated neurocognitive disorders per- sist in the era of potent antiretroviral therapy: CHARTER Study 显示文摘Heaton RK Clifford DB Franklin Dr Jr 2010Neurology2010,75,:1
7HIV-associatedneurocognitive disorders before and during the era ofcombination antiretroviral therapy: differences in rates,nature, and predictors 显示文摘Heaton RK Franklin DR Ellis RJ 2011J Neurovirol2011,17,1:1
8HIV-associated neurocognitive disorders persist in the era ofpotent antiretroviral therapy: CHARTER study 显示文摘Heaton RK Clifford DB Franklin DR Jr 2010Neurology2010,75,23:1
9HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy:CHARTER Study显示文摘Heaton RK Clifford DB Franklin DR 2010Neurology2010,75,23:1
10HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy:differences in rates,nature,and predictors显示文摘Heaton RK Franklin DR Ellis RJ 2011J Neurovirol2011,17,1:1
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