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| 1 | 气候变化和紫外线辐射对北极淡水鱼类及溯河产卵鱼类渔业的影响显示文摘北极淡水鱼类和洄游鱼类渔业为北方经济做出了重大贡献。但是,对于淡水水体,气候变化和增长的紫外线辐射对渔业产生的巨大影响有3个方面:可获鱼的数量、质量和捕捞成功率。因此,在这些影响发生作用之际,可能需要实质有效的适应行为以引导北极未来的渔业走向可持续性。当务之急是为商业渔业选择灵活和快速反应的'适宜管理'方式;改变生计渔业的当地土地和资源利用模式;改变很多休闲渔业的特性、管理方式和地点。总的来说,在气候变化及其对北极淡水水域和生物区影响的复杂性和不确定性情况下,为保证生态系统和主导鱼种有足够的恢复力和应对将来变化的能力,需要对渔业的各个方面实施更保守的管理办法。 | James D.Reist Frederick J.Wrona Terry D.Prowse J.Brian Dempson Michael Power Günter Kck Theresa J.Carmichael Chantelle D.Sawatzky Hannu Lehtonen Ross F.Tallman 曾首英 | 2006 | AMBIO-人类环境杂志2006，35，7： | 4 |
| 2 | A Randomized, Prospective, Double-Blind, Placebo-Controlled Trial of Terlipressin for Type 1 Hepatorenal Syndrome显示文摘 | Arun J. Sanyal Thomas Boyer Guadalupe Garcia–Tsao Frederick Regenstein Lorenzo Rossaro Beate Appenrodt Andres Blei Veit Gülberg Samuel Sigal Peter Teuber | 2008 | Gastroenterology2008，，5： | 3 |
| 3 | Serelaxin increases the antifibrotic action of rosiglitazone in a model of hepatic fibrosis显示文摘AIM To determine the effect of combined serelaxin and rosiglitazone treatment on established hepatic fibrosis.METHODS Hepatic fibrosis was induced in mice by carbon tetrachloride administration for 6 wk, or vehicle alone(nonfibrotic mice). For the final 2 wk, mice were treated with rosiglitazone, serelaxin, or both rosiglitazone and serelaxin. Serum liver enzymes and relaxin levels were determined by standard methods. The degree of liver collagen content was determined by histology and immunohistochemistry. Expression of type?Ⅰ?collagen was determined by quantitative PCR. Activation of hepatic stellate cells was assessed by alpha-smoothmuscle actin(SMA) levels. Liver peroxisome proliferator activated receptor-gamma coactivator 1 alpha(PGC1α) was determined by Western blotting.RESULTS Treatment of mice with CCl4 resulted in hepatic fibrosis as evidenced by increased liver enzyme levels(ALT and AST), and increased liver collagen and SMA. Monotherapy with either serelaxin or rosiglitazone for 2 wk was generally without effect. In contrast, the combination of serelaxin and rosiglitazone resulted in significantly improved ALT levels(P < 0.05). Total liver collagen content as determined by Sirius red staining revealed that only combination treatment was effective in reducing total liver collagen(P < 0.05). These results were supported by immunohistochemistry for type?Ⅰ?collagen, in which only combination treatment reduced fibrillar collagen levels(P < 0.05). The level of hepatic stellate cell activation was modestly, but significantly, reduced by serelaxin treatment alone, but combination treatment resulted in significantly lower SMA levels. Finally, while hepatic fibrosis reduced liver PGC1α levels, the combination of serelaxin and rosiglitazone resulted in restoration of PGC1α protein levels.CONCLUSION The combination of serelaxin and rosiglitazone treatment for 2 wk was effective in significantly reducing established hepatic fibrosis, providing a potential new treatment strategy. | Robert G Bennett Ronda L Simpson Frederick G Hamel | 2017 | World Journal of Gastroenterology2017，23，22： | 2 |
| 4 | A Randomized, Prospective, Double-Blind, Placebo-Controlled Trial of Terlipressin for Type 1 Hepatorenal Syndrome显示文摘 | Arun J. Sanyal Thomas Boyer Guadalupe Garcia–Tsao Frederick Regenstein Lorenzo Rossaro Beate Appenrodt Andres Blei Veit Gülberg Samuel Sigal Peter Teuber | 2008 | Gastroenterology2008，，5： | 2 |
| 5 | Structura1 comparison of anticancer drug- DNA complexes:adriamycin and daunomycin显示文摘 | Wi11iams L D Ughetto G | 1990 | Biochemistry1990，29，10： | 1 |
| 6 | 显示文摘 | TORRES-VEGA G FREDERICK J H | 1990 | J Chem Phys1990，93，12： | 1 |
| 7 | Analysis of hybrid-electric pro- pulsion system designs for small unmanned aircraft system 显示文摘 | Hiserote R Frederick G | 2010 | AIAA2010，6687，： | 1 |
| 8 | Adenosquamous carcinoma of the colon : a rare tumor显示文摘 | Kiran R P Tripodi G Frederick W | 2006 | Am Surg2006，72，： | 1 |
| 9 | Safety and immunogenicity of a baculovims-expressed hemagglutinin influenza vaccine: a randomized controlled trial显示文摘 | John J T Gillbert M S Frederick G H | 2007 | JAMA2007，297，14： | 1 |
| 10 | Strategic Outsourcing 显示文摘 | Frederick G Hilmer | 1994 | Sloan Management Review1994，35，4： | 1 |
| 11 | 显示文摘 | TORRES-VEGA G FREDERICK J H | 1999 | Phys Rev Lett1999，67，19： | 1 |
| 12 | Printed circuit board technology inspired stretchable circuits 显示文摘 | JAN V MARIO G FREDERICK B etal | 2012 | MRS Bulletin2012，37，3： | 1 |
| 13 | Finite element analysis of steel girder highway bridges 显示文摘 | Mabsout M E Tarhini K M Frederick G R Tayar C | 2002 | Journal of bridge Engineering2002，7，5： | 1 |
| 14 | 2009 Focused Updates: ACC/AHA Guidelines for the Management of Patients With ST-- Elevation Myocardial Infarction (Updating the 2004 Guideline and 2007 Focused Update) and ACC/AHA/SCAI Guidelines on Percu- taneous Coronary Intervention (Updating the 2005 Guideline and 2007 Focused Update) : A Report of the American College of Cardi- ology Foundation/American Heart Association Task Force on Prac- tice Guidelines显示文摘 | Frederick G K Mary H Sidney C S | 2009 | JACC2009，54，23： | 1 |
| 15 | Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas显示文摘 | Frederick L Wang XY Eley G | | 0，，05： | 1 |
| 16 | Quantum Mechanics in Phase Space: New Approaches to Correspondence Prin ciple显示文摘 | TORRES-VEGA G FREDERICK J H | 1990 | J Chem Phys1990，93，： | 1 |
| 17 | Atmospheric Propagation of Radiation,Bellingham显示文摘 | Frederick G Smith | 1993 | Optical Engineering1993，，： | 1 |
| 18 | Clinical simulation and foundation skills:an integrated multidisciplinary approach to teaching显示文摘 | Frederick G | 2004 | J Dent Educ2004，68，4： | 1 |
| 19 | A Quantum Mechanical Representation in Phase Space显示文摘 | TORRES VEGA G FREDERICK J H | 1992 | J Chem Phys1992，98，： | 1 |
| 20 | Quantum mechanics in phase space:new approaches to the correspondence principle显示文摘 | TORRES-VEGA G FREDERICK J H | 1990 | J Chem Phys1990，93，： | 1 |
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