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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Reprogramming of a defense signaling pathway in rough lemon and sweet orange is a critical element of the early response to‘Candidatus Liberibacter asiaticus’显示文摘Huanglongbing(HLB)in citrus infected by Candidatus Liberibacter asiaticus(CLas)has caused tremendous losses to the citrus industry.No resistant genotypes have been identified in citrus species or close relatives.Among citrus varieties,rough lemon(Citrus jambhiri)has been considered tolerant due to its ability to produce a healthy flush of new growth after infection.The difference between tolerance and susceptibility is often defined by the speed and intensity of a plant’s response to a pathogen,especially early defense responses.RNA-seq data were collected from three biological replicates of CLas-and mock-inoculated rough lemon and sweet orange at week 0 and 7 following infection.Functional analysis of the differentially expressed genes(DEGs)indicated that genes involved in the mitogen activated protein kinase(MAPK)signaling pathway were highly upregulated in rough lemon.MAPK induces the transcription of WRKY and other transcription factors which potentially turn on multiple defense-related genes.A Subnetwork Enrichment Analysis further revealed different patterns of regulation of several functional categories,suggesting DEGs with different functions were subjected to reprogramming.In general,the amplitude of the expression of defense-related genes is much greater in rough lemon than in sweet orange.A quantitative disease resistance response may contribute to the durable tolerance level to HLB observed in rough lemon. | Qibin Yu Chunxian Chen Dongliang Du Ming Huang Jiqiang Yao Fahong Yu Ronald H Brlansky Frederick G.Gmitter Jr | 2017 | Horticulture Research2017，4，1： | 5 |
| 3 | Carbonatites and Alkaline Igneous Rocks in Post-Collisional Settings:Storehouses of Rare Earth Elements显示文摘The rare earth elements(REE)are critical raw materials for much of modern technology,particularly renewable energy infrastructure and electric vehicles that are vital for the energy transition.Many of the world's largest REE deposits occur in alkaline rocks and carbonatites,which are found in intracontinental,rift-related settings,and also in syn-to post-collisional settings.Post-collisional settings host significant REE deposits,such as those of the Mianning-Dechang belt in China.This paper reviews REE mineralization in syn-to post-collisional alkaline-carbonatite complexes worldwide,in order to demonstrate some of the key physical and chemical features of these deposits.We use three examples,in Scotland,Namibia,and Turkey,to illustrate the structure of these systems.We review published geochemical data and use these to build up a broad model for the REE mineral system in post-collisional alkaline-carbonatite complexes.It is evident that immiscibility of carbonate-rich magmas and fluids plays an important part in generating mineralization in these settings,with REE,Ba and F partitioning into the carbonate-rich phase.The most significant REE mineralization in post-collisional alkaline-carbonatite complexes occurs in shallow-level,carbothermal or carbonatite intrusions,but deeper carbonatite bodies and associated alteration zones may also have REE enrichment. | Kathryn M.Goodenough Eimear A.Deady Charles D.Beard Sam Broom-Fendley Holly ALElliott Frederick van den Berg HüseyinÖztürk | 2021 | Journal of Earth Science2021，32，6： | 2 |
| 4 | 显示文摘 | TORRES-VEGA G FREDERICK J H | 1990 | J Chem Phys1990，93，12： | 1 |
| 5 | Safety and immunogenicity of a baculovims-expressed hemagglutinin influenza vaccine: a randomized controlled trial显示文摘 | John J T Gillbert M S Frederick G H | 2007 | JAMA2007，297，14： | 1 |
| 6 | 显示文摘 | TORRES-VEGA G FREDERICK J H | 1999 | Phys Rev Lett1999，67，19： | 1 |
| 7 | Optimal Path Planning for UCAV to Defeat Radar Tracking 显示文摘 | Pierre T K Semyou M M Frederick H Z | 2006 | Journal of Guidance Control and Dynamics March-April2006，29，2： | 1 |
| 8 | Human Error:A Concept Analysis显示文摘 | Frederick D H | 2006 | Journal of AirTransportation2006，11，3： | 1 |
| 9 | Induced sputum in the management of asthma显示文摘 | Pizzichini MMM Frederick E H | 1995 | Seminars in Respiratory and Critical Care Medicine1995，19，6： | 1 |
| 10 | Dimethyl secondary amine chain extenders: a conceptual approach to in situ generation of advanced epoxy resins for rapid cure, lowVOC coatings显示文摘 | FREDERICK H WALKER MICHAEL COOK GAMINI VEDAGE | 2009 | J Coat Technol Res2009，6，3： | 1 |
| 11 | 2009 Focused Updates: ACC/AHA Guidelines for the Management of Patients With ST-- Elevation Myocardial Infarction (Updating the 2004 Guideline and 2007 Focused Update) and ACC/AHA/SCAI Guidelines on Percu- taneous Coronary Intervention (Updating the 2005 Guideline and 2007 Focused Update) : A Report of the American College of Cardi- ology Foundation/American Heart Association Task Force on Prac- tice Guidelines显示文摘 | Frederick G K Mary H Sidney C S | 2009 | JACC2009，54，23： | 1 |
| 12 | Power amplifiers and transmitters for RF and microwave 显示文摘 | Frederick H Raab peter asbeck steve cripps | 2002 | IEEE transactions on microwave theory and techniques( S0018 - 9480)2002，50，3： | 1 |
| 13 | Quantum Mechanics in Phase Space: New Approaches to Correspondence Prin ciple显示文摘 | TORRES-VEGA G FREDERICK J H | 1990 | J Chem Phys1990，93，： | 1 |
| 14 | Glucosidases and exo-glucanases显示文摘 | Elwyn T Reese Anne H Maguire Frederick W Parrish | 1968 | Canadian Journal ofBiochemistry1968，46，1： | 1 |
| 15 | A Quantum Mechanical Representation in Phase Space显示文摘 | TORRES VEGA G FREDERICK J H | 1992 | J Chem Phys1992，98，： | 1 |
| 16 | Quantum mechanics in phase space:new approaches to the correspondence principle显示文摘 | TORRES-VEGA G FREDERICK J H | 1990 | J Chem Phys1990，93，： | 1 |
| 17 | Power Amplifiers and Transmitters for RF and Microwave 显示文摘 | Frederick H Raab etal | 2002 | MTT IEEE Trans2002，50，3： | 1 |
| 18 | Optimal path planning for unmanned combat aerial vehi- cles to defeat radar tracking 显示文摘 | Pierre T Kabamba Semyon Meerkov Frederick H Zeitz | 2006 | Journal of Guidance Control and Dynamics2006，29，2： | 1 |
| 19 | A computerized method of visual acuity testing显示文摘 | Roy W Beck Pamela S Moke Andrew H Turpin Frederick L Ferris John Paul SanGiovanni Chris A Johnson Eileen E Birch Danielle L Chandler Terry A Cox R.Clifford Blair Raymond T Kraker | 2003 | American Journal of Ophthalmology2003，，2： | 1 |
| 20 | The cellular response to general and proammed DNA double strand breaks显示文摘 | FREDERICK W A | 2004 | DNA Rep2004，3，： | 1 |
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