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| 1 | Efficacy of sequential treatment of HCT116 colon cancer monolayers and xenografts with docetaxel,flavopiridol,and 5-fluorouracil显示文摘瞄准:有 docetaxel, flavopiridol,或 5 氟尿嘧啶(5-FU ) 的稳固的肿瘤的临床的治疗经常遇到不受欢迎的副作用和药抵抗。在 modulating chemosensitivity 并且更好与 docetaxel, flavopiridol,或 5-FU 评估联合治疗的潜在的角色的目的理解他们怎么可能临床上被使用的这研究。方法:HCT116 结肠癌房间在几不同行政时间表在试管内与 docetaxel, flavopiridol,和 5-FU 被对待,顺序或同时。房间幸存被 MTT 试金测量。caspase-3 的活动被 caspase-3 试金决定,软琼脂殖民地试金被用来在软琼脂测试 HCT116 房间的菌落形成。我们也建立了异种皮移植模型扩大在试管内观察到一个在活体内系统。结果:当人的结肠癌 HCT116 房间为 flavopiridol 为另一 24 h 为 24 h 和 5-FU 跟随的 1 h 与 docetaxel 被对待时,最大的细胞毒性被发现。这顺序的联合治疗不仅与另外的联合治疗相比更强烈禁止肿瘤细胞生长而且显著地在软琼脂减少菌落形成并且扩充 HCT116 细胞的 apoptosis。docetaxel 定序以后由 flavopiridol 跟随了 1 h,以后在异种皮移植模型由 5-FU 跟随了 24 h,也导致了推迟的肿瘤生长和更高的幸存率。结论:当把 docetaxel 与 flavopiridol 和 5-FU 相结合时,这些结果强调一张行政时间表的重要性,提供对它在临床的试用的发展的基本原理解释。 | Jun GUO An-wu ZHOU Yu-cai FW Udit N VERMA Debu TRIPATHY Eugene P FRENKEL Carlos R BECERRA | 2006 | Acta Pharmacologica Sinica2006，27，10： | 4 |
| 2 | Transforming growth factor beta superfamily members: role in cartilage modeling 显示文摘 | Frenkel S R Saadeh P B Mehrara B J | 2000 | Plast Reconstr Surg2000，105，3： | 1 |
| 3 | Rituximab in combination with CHOP regimen in angioimmunoblastic T-cell lymphoma (AITL) : preliminary results in 9 patients treated in a single institution显示文摘 | Joly B Frenkel V Gaulard P | 2005 | Blood2005，106，： | 1 |
| 4 | Enhancement of Protein Crystal Nucleation by Critical Density Fluctuations显示文摘 | Wolde P R Frenkel D | 1997 | Science1997，277，5334： | 1 |
| 5 | The paradoxical effect of bevaeizumab in the therapy of malignant gliomas 显示文摘 | Thompson E M Frenkel E P Neuwelt E A | 2011 | Neurology2011，76，1： | 1 |
| 6 | Presence of osteocalcin and related higher molecular weight 4-earbox- yglutamic acid-containing proteins in developing bone显示文摘 | HAUSCHKA P V FRENKEL J DEMUTH R | 1983 | J Bi- ol Chem1983，258，1： | 1 |
| 7 | Depletion effects in binary hard-sphere fluids显示文摘 | Biben T Bladon P Frenkel D | 1996 | J Phys Condens Matter1996，8，10： | 1 |
| 8 | Test characteristics of the aldosterone-to-renin ratio as a screening test for primary aldosteronism显示文摘 | Jansen P M van-den-Born B H Frenkel W J | 2014 | J Hypertens2014，32，1： | 1 |
| 9 | Unusual eye abnormalities associated with congenital cytomegalovirus infection显示文摘 | Frenkel L D Keys M P Hefferen S J | 1980 | Pediatrics1980，66，5： | 1 |
| 10 | Scaffolds for Articular Cartilage Repair 显示文摘 | Frenkel S R Di-Cesare P E | 2004 | Ann Biomed Eng2004，32，1： | 1 |
| 11 | Scaffolds for articular cartilage repair显示文摘 | Frenkel S R Di Cesare P E | 2004 | Ann Biomed Eng2004，32，1： | 1 |
| 12 | Thermodynamics of global optimization显示文摘 | Doye J P Sear R Frenkel D | 1998 | J Chem Phys1998，108，： | 1 |
| 13 | Toxoplasma gondii life cycle in cats显示文摘 | Dubey J P Miller N L Frenkel J K | 1970 | J Am Vet Med Assoc1970，157，11： | 1 |
| 14 | Toxoplasma gondii in cats: fecal stages identified as coccidian oocysts显示文摘 | Frenkel J K Dubey J P Miller N L | 1970 | Science1970，167，3919： | 1 |
| 15 | Cyst- induced toxoplasmosis in cats显示文摘 | Dubey J P Frenkel J K | 1972 | J Protozool1972，19，1： | 1 |
| 16 | Transforming growth factor beta superfamily members : role in cartilage modeling 显示文摘 | Frenkel S Saadeh P Mehrara B | 2000 | Plastic Reconstr Surg2000，105，3： | 1 |
| 17 | Aneusomy 17in breast cancer: its role in HER-2/neu protein expression andimplication for clinical assessment of HER-2/neu status显示文摘 | Wang S Hossein Saboorian M Frenkel E P | 2002 | ModPathol2002，5，2： | 1 |
| 18 | Optimization of ultrasotmd parameters for cardiac gene delivery of adenoviral or plasmid deoxyflbonucleic acid by ultrasound-targeted microbttbble destruction显示文摘 | Chen S Shohet RV Bekeredjian R Frenkel P Gravburn PA | 2003 | J Am Coil Cardial2003，42，2： | 1 |
| 19 | Circulating tumor cells in patients with breast cancer dormancy 显示文摘 | Meng S Tripathy D Frenkel E P | 2004 | Clin Cancer Res2004，10，24： | 1 |
| 20 | Understanding the phase-change mechanism of rewritable optical media显示文摘 | KOLOBOV A V FONS P FRENKEL A I | 2004 | Nature Materials2004，3，10： | 1 |
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