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| 1 | Late biliary complications in human alveolar echinococcosis are associated with high mortality显示文摘AIM:To evaluate the incidence of late biliary complications in non-resectable alveolar echinococcosis(AE)under long-term chemotherapy with benzimidazoles.METHODS:Retrospective analysis of AE patients with biliary complications occurring more than three years after the diagnosis of AE.We compared characteristics of patients with and without biliary complications,analyzed potential risk factor for biliary complications and performed survival analyses.RESULTS:Ninety four of 148 patients with AE in Zurich had non-resectable AE requiring long-term benzimidazole chemotherapy,of which 26(28%)patients developed late biliary complications.These patients had a median age of 55.5(35.5-65)years at diagnosis of AE and developed biliary complications after 15(8.25-19)years of chemotherapy.The most common biliary complications during long-term chemotherapy were late-onset cholangitis(n=14),sclerosing cholangitis-like lesions(n=8),hepatolithiasis(n=5),affection of the common bile duct(n=7)and secondary biliary cirrhosis(n=7).Thirteen of the 26 patients had undergone surgery(including 12 resections)before chemotherapy.Previous surgery was a risk factor for late biliary complications in linear regression analysis(P=0.012).CONCLUSION:Late biliary complications can be observed in nearly one third of patients with non-resectable AE,with previous surgery being a potential risk factor.After the occurrence of late biliary complications,the median survival is only 3 years,suggesting that late biliary complications indicate a poor prognostic outcome. | Pascal Frei Benjamin Misselwitz Meher K Prakash Alain M Schoepfer Bettina M Prinz Vavricka Beat Müllhaupt Michael Fried Kuno Lehmann Rudolf W Ammann Stephan R Vavricka | 2014 | World Journal of Gastroenterology2014，20，19： | 5 |
| 2 | 激活β_3肾上腺素能受体恢复一氧化氮/氧化还原平衡,增强高血糖患者的内皮功能显示文摘一氧化氮与O_2^-之间的平衡紊乱(即一氧化氮/氧化还原失衡)是糖尿病引起的血管功能障碍的中心病理环节。该研究目的为在高血糖动物模型中探索β_3肾上腺素能受体(β_3adrenergic receptor,β3AR)激活能否耦合激活内皮型一氧化氮合酶(endothelial nitric oxide synthase,eNOS)。 | 刘莉 叶鹏 Karimi Galougahi K Liu CC Garcia A Gentile C Fry NA Hamilton EJ Hawkins CL Figtree GA | 2016 | 中华高血压杂志2016，24，3： | 2 |
| 3 | Accounting for Environment Effects and Statisticalnoise in Data Envelopment Analysis显示文摘 | Fried H O Lovell C A K Schmidt S S Yaisawarng S | 2002 | Journal of Productivi- ty Analysis2002，17，12： | 1 |
| 4 | Dissection of Genetic Factors Modulating Fetal Growth in Cattle Indicates a Substantial Role of the Non-SMC Condensin I Complex, Subunit G (NCAPG) Gene显示文摘 | Eberlein Annett Takasuga Akiko Setoguchi Kouji Pfuhl Ralf Flisikowski Krzysztof Fries Ruedi Klopp Norman Fürbass Rainer Weikard Rosemarie Kühn Christa | 2009 | Genetics2009，，3： | 1 |
| 5 | Inhibin B predicts oocyte number and the ratio IGF-I/IGFBP-1 may indicate oocyte quality during ovarian hyperstimulation for in vitro fertilization显示文摘 | Fried G Remaeus K Harlin J | 2003 | J Assist Reprod Genet2003，20，5： | 1 |
| 6 | Small-bowel endoscopy 显示文摘 | Monkemuller K Olano C Fry LC | 2009 | Endoscopy2009，41，10： | 1 |
| 7 | An inverse dynamic model of the Gough-Stewart platform显示文摘 | FRIED G DJOUANI K BOROJENI D | 2008 | WSEAS Transactions on Systems2008，7，2： | 1 |
| 8 | Reproductive and morphological effects of o,p' -dicofol on two genera- tions of captive American Kestrels 显示文摘 | MacLellan K N M Bird D M Fry D M | 1996 | Achives of Environ- mental Contamination and Toxicology1996，30，3： | 1 |
| 9 | Stratospheric residence time of strontium,90 显示文摘 | Kuroda P K Hodges H L Fry L M Moore H E | 1962 | Science1962，137，3523： | 1 |
| 10 | Accounting for Environmental Effects and Statistical Noise in Data Envelopment Analysis显示文摘 | Fried H O Lovell C A K Schmidt S S | 2002 | Journal of productivity Analysis2002，，17： | 1 |
| 11 | Histidine kinases and response regulators in networks显示文摘 | JUNG K FRIED L BEHR S | 2012 | t Opinionin Microbiology2012，15，2： | 1 |
| 12 | OWLS-MX:A Hybrid Semantic Web Service Matchmaker for OWL-S Services显示文摘 | Klusch M Fries B Sycara K | 2009 | Web Semantics:Science Services and Agents on the World Wide Web2009，7，2： | 1 |
| 13 | The human organic anion transporter 2 gene is transactivated by hepatocyte nuclear factor-4 alpha and suppressed by bile acids显示文摘 | Popowski K Eloranta JJ Saborowski M Fried M Meier PJ Kullak-Ublick GA | 2005 | Mol Pharmacol2005，67，5： | 1 |
| 14 | Somatotropin regulates adipose tissue metabolism in neonatal swine显示文摘 | WANG Y X FRIED S K PETERSEN R N | 1999 | J Nutr1999，129，1： | 1 |
| 15 | Presumptive dirofilariasis in a pale-headed saki monkey (Pithecia pithecia )显示文摘 | GANBLE K C FRIED J J RUBIN G J | 1998 | J Zool Wildl Med1998，29，1： | 1 |
| 16 | A novel conserved nuclear localization signal is recognized by a group of yeast importins 显示文摘 | Fries T Betz C Sohn K | 2007 | J Biol Chem2007，，19： | 1 |
| 17 | A new subspecies of Acrocephalus baeticatus from Lake Chad and a taxonomic reappraisal of Acrocephalus dumetorum显示文摘 | Fry CH Williamson K Ferguson-Lees IJ | | 0，，： | 1 |
| 18 | Influenza B viruses with mu- tation in the neuraminidase active site, North Carolina, USA, 2010-11显示文摘 | Sleeman K Sheu T G Moore Z Kilpatrick S Garg S Fry A M Gubareva L V | 2011 | Emerg Infect Dis2011，17，11： | 1 |
| 19 | Small-molecule inhibitors of Bcl-2 显示文摘 | Manion M K Fry J Schwartz P S | 2006 | Curr Opin Investig Drugs2006，7，12： | 1 |
| 20 | Accounting for environmental effects and statistical noise in data en- velopment analysis显示文摘 | Fried H O Lovell C K Schmist S S | 2002 | Journal of Productivity Analysis2002，17，12： | 1 |
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