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| 1 | Late biliary complications in human alveolar echinococcosis are associated with high mortality显示文摘AIM:To evaluate the incidence of late biliary complications in non-resectable alveolar echinococcosis(AE)under long-term chemotherapy with benzimidazoles.METHODS:Retrospective analysis of AE patients with biliary complications occurring more than three years after the diagnosis of AE.We compared characteristics of patients with and without biliary complications,analyzed potential risk factor for biliary complications and performed survival analyses.RESULTS:Ninety four of 148 patients with AE in Zurich had non-resectable AE requiring long-term benzimidazole chemotherapy,of which 26(28%)patients developed late biliary complications.These patients had a median age of 55.5(35.5-65)years at diagnosis of AE and developed biliary complications after 15(8.25-19)years of chemotherapy.The most common biliary complications during long-term chemotherapy were late-onset cholangitis(n=14),sclerosing cholangitis-like lesions(n=8),hepatolithiasis(n=5),affection of the common bile duct(n=7)and secondary biliary cirrhosis(n=7).Thirteen of the 26 patients had undergone surgery(including 12 resections)before chemotherapy.Previous surgery was a risk factor for late biliary complications in linear regression analysis(P=0.012).CONCLUSION:Late biliary complications can be observed in nearly one third of patients with non-resectable AE,with previous surgery being a potential risk factor.After the occurrence of late biliary complications,the median survival is only 3 years,suggesting that late biliary complications indicate a poor prognostic outcome. | Pascal Frei Benjamin Misselwitz Meher K Prakash Alain M Schoepfer Bettina M Prinz Vavricka Beat Müllhaupt Michael Fried Kuno Lehmann Rudolf W Ammann Stephan R Vavricka | 2014 | World Journal of Gastroenterology2014，20，19： | 5 |
| 2 | Reproductive and morphological effects of o,p' -dicofol on two genera- tions of captive American Kestrels 显示文摘 | MacLellan K N M Bird D M Fry D M | 1996 | Achives of Environ- mental Contamination and Toxicology1996，30，3： | 1 |
| 3 | Stratospheric residence time of strontium,90 显示文摘 | Kuroda P K Hodges H L Fry L M Moore H E | 1962 | Science1962，137，3523： | 1 |
| 4 | OWLS-MX:A Hybrid Semantic Web Service Matchmaker for OWL-S Services显示文摘 | Klusch M Fries B Sycara K | 2009 | Web Semantics:Science Services and Agents on the World Wide Web2009，7，2： | 1 |
| 5 | The human organic anion transporter 2 gene is transactivated by hepatocyte nuclear factor-4 alpha and suppressed by bile acids显示文摘 | Popowski K Eloranta JJ Saborowski M Fried M Meier PJ Kullak-Ublick GA | 2005 | Mol Pharmacol2005，67，5： | 1 |
| 6 | Influenza B viruses with mu- tation in the neuraminidase active site, North Carolina, USA, 2010-11显示文摘 | Sleeman K Sheu T G Moore Z Kilpatrick S Garg S Fry A M Gubareva L V | 2011 | Emerg Infect Dis2011，17，11： | 1 |
| 7 | Small-molecule inhibitors of Bcl-2 显示文摘 | Manion M K Fry J Schwartz P S | 2006 | Curr Opin Investig Drugs2006，7，12： | 1 |
| 8 | Sinks for 15N - enriched addi-tions to an oak forest and a red pine plantation显示文摘 | Nadelhoffer K J Downs M R Fry B | 1999 | Ecological Appli-cations1999，，： | 1 |
| 9 | Crucial weather conditions for Phytophthora infestans - a reliable tool for improved control of potato late blight显示文摘 | Cao K Q Forrer H R Fried P M | 1996 | PAV Special Report1996，，1： | 1 |
| 10 | Mito-FLAG as salvage therapy for relapsed and refractory acute myeloid leukemia显示文摘 | HANEL M FRIED R K HANEL A et aL | 2001 | Onkologie2001，24，4： | 1 |
| 11 | Nerve Injury Induced Pain in the Trigeminal System显示文摘 | Fried K Bongenhietm F Boissonade M | 2001 | Neuroscientist2001，7，2： | 1 |
| 12 | Theory-guided bottom-up design of b-titanium alloys as biomaterials based on first principles calculations:Theory and experiments显示文摘 | RAABE D SANDER B FRIáK M | 2007 | Acta Materialia2007，55，10： | 1 |
| 13 | Global land cover mapping from MODIS : Algorithms and early results 显示文摘 | Fried M A McIver D K Hodges J C F | 2002 | Remote Sensing of Environment2002，83，12： | 1 |
| 14 | Peginter-feron alfa~2a plus ribavirin for chronic hepatitis C virus infec-tion显示文摘 | FRIED M W SHIFFMAN M L REDDY K R | 2002 | N Engl J Med2002，347，13： | 1 |
| 15 | A reconfigurable slot antenna with switchable polarization显示文摘 | FRIES M K GRANI M and VAHLDIECK R | 2003 | IEEE Microwave and Wireless Components Letters2003，13，11： | 1 |
| 16 | Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection显示文摘 | Fried M Shiffman M Reddy K | 2002 | New England Journal of Medicine2002，，： | 1 |
| 17 | Trends in hospitalizations for pneumonia among persons aged 65 years or older in the United States显示文摘 | Fry A M Shay D K Holman R C | 2005 | JAMA2005，294，21： | 1 |
| 18 | Crucial weather conditions for Phytophthora infestans-a reliable tool for improved control of potato late blight 显示文摘 | Cao K Q Forrer H R Fried P M | 1996 | PAV Special Report1996，，1： | 1 |
| 19 | OWLS-MX:A hybid semantic Web service matchmaker for OWL-S services显示文摘 | Kluseh M Fries B Syeara K | | 0，，02： | 1 |
| 20 | Effects of the anthelmintics clorsulon, rafoxande, mebendazole and arapinocid on Echinosma caproni in ICR mice显示文摘 | Decere M Fried B | 1995 | J Helminthol1995，69，4： | 1 |
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