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| 1 | Delayed atomoxetine or fluoxetine treatment coupled with limited voluntary running promotes motor recovery in mice after ischemic stroke显示文摘Currently, there is an unmet need for treatments promoting post-stroke functional recovery.The aim of this study was to evaluate and compare the dose-dependent effect of delayed atomoxetine or fluoxetine therapy(starting on post-stroke day 5), coupled with limited physical exercise(2 hours daily voluntary wheel running;post-stroke days 9 to 42), on motor recovery of adult male mice after photothrombotic stroke.These drugs are selective norepinephrine or serotonin reuptake inhibitors indicated for disorders unrelated to stroke.The predetermined primary end-point for this study was motor function measured in two tasks of spontaneous motor behaviors in grid-walking and cylinder tests.Additionally, we quantified the running distance and speed throughout the study, the number of parvalbumin-positive neurons in the medial agranular cortex and infarct volumes.Both sensorimotor tests revealed that neither limited physical exercise nor a drug treatment alone significantly facilitated motor recovery in mice after stroke.However, combination of physical exercise with either of the drugs promoted restoration of motor function by day 42 post-stroke, with atomoxetine being a more potent drug.This was accompanied by a significant decrease in parvalbumin-positive inhibitory interneurons in the ipsilateral medial agranular cortex of mice with recovering motor function, while infarct volumes were comparable among experimental groups.If further validated in larger studies, our observations suggest that add-on atomoxetine or fluoxetine therapy coupled with limited, structured physical rehabilitation could offer therapeutic modality for stroke survivors who have difficulty to engage in early, high-intensity physiotherapy.Furthermore, in light of the recently completed Assessment o F Fluoxet INe In s Troke recover Y(AFFINITY) and Efficacy o F Fluoxetine-a randomis Ed Controlled Trial in Stroke(EFFECTS) trials, our observations call for newly designed studies where fluoxetine or atomoxetine pharmacotherapy is evaluated in combination with structured physical rehabilitation rather than alone.This study was approved by the Texas Tech University Health Sciences Center Institutional Animal Care and Use Committee(protocol # 16019). | Faisal F.Alamri Abdullah Al Shoyaib Nausheen Syeara Anisha Paul Srinidhi Jayaraman Serob T.Karamyan Thiruma V.Arumugam Vardan T.Karamyan | 2021 | Neural Regeneration Research2021，16，7： | 2 |
| 2 | Bayesian learning in negotiation显示文摘 | Zeng Dajun Syeara K | 1998 | Int J Human-Computer Studies1998，48，： | 1 |
| 3 | Reaching agreement through argumentation: A logical model and implementation显示文摘 | Kraus S Syeara K Evenchik A | 1998 | Artificial Intelligence1998，104，12： | 1 |
| 4 | A roadmap of Agent research and development显示文摘 | N R Jennings K Syeara M Wooddrige | 1998 | Autonomous Agents and Multi-Agent Systems1998，，1： | 1 |
| 5 | OWLS-MX:A hybid semantic Web service matchmaker for OWL-S services显示文摘 | Kluseh M Fries B Syeara K | | 0，，02： | 1 |
| 6 | Distributed Intelligent Agents 显示文摘 | Syeara K Decker K Pannu A | 1996 | IEEE Expert1996，11，5： | 1 |
| 7 | Reaching Agreements through Argumentation:A Lgical Model and Implmenmfion显示文摘 | Kraus S Syeara K Evenchik A | 1998 | Artifi-cial Intelligence1998，，1： | 1 |
| 8 | A Roadmap of Agent Research and Development显示文摘 | Jennings N R Syeara K Wooldridge M | 1998 | Autonomous Agents and Multi-Agent System1998，10，2： | 1 |
| 9 | Distributed intelligent agents显示文摘 | Syeara K | 1996 | IEEE Expert1996，11，5： | 1 |
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