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| 1 | Cetuximab plus FOLFOX6 or FOLFIRI in metastatic colorectal cancer: CECOG trial显示文摘AIM: To investigate efficacy and safety of cetuximab combined with two chemotherapy regimens in patients with unresectable metastatic colorectal cancer (mCRC). METHODS: Randomized patients received cetuximab with 5-fluorouracil (5-FU), folinic acid (FA) and oxaliplatin (FOLFOX) 6 (arm A, n = 74) or 5-FU, FA and irinotecan (FOLFIRI) (arm B, n = 77). KRAS mutation status was determined retrospectively in a subset of tumors (n = 117). RESULTS: No significant difference was found between treatment arms A and B in the progression-free survival (PFS) rate at 9 mo, 45% vs 34%; median PFS, 8.6 mo vs 8.3 mo [hazard ratio (HR) = 1.06]; overall response rate (ORR) 43% vs 45% [odds ratio (OR) = 0.93] and median overall survival (OS), 17.4 mo vs 18.9 mo (HR = 0.98). Patients with KRAS wild-type tumors demonstrated improved PFS (HR = 0.55, P = 0.0051), OS, (HR = 0.62, P = 0.0296) and ORR (53% vs 36%) and in arm A, improved PFS (HR = 0.49, P = 0.0196), OS (HR = 0.48, P = 0.0201) and ORR (56%vs 30%), compared with patients with KRAS mutated tumors. In arm B no significant differences were found in efficacy by KRAS mutation status. Treatment in arms A and B was generally well tolerated. CONCLUSION: This study confirms that combinations of cetuximab with FOLFOX6 or FOLFIRI are effective and significantly improve clinical outcome in KRAS wild-type compared with KRAS mutated mCRC. | Janja Ocvirk Thomas Brodowicz Fritz Wrba Tudor E Ciuleanu Galina Kurteva Semir Beslija Ivan Koza Zsuzsanna Pápai Diethelm Messinger Ugur Yilmaz Zsolt Faluhelyi Suayib Yalcin Demetris Papamichael Miklós Wenczl Zrinka Mrsic-Krmpotic Einat Shacham-Shmueli Damir Vrbanec Regina Esser Werner Scheithauer Christoph C Zie-linski | 2010 | World Journal of Gastroenterology2010，16，25： | 17 |
| 2 | PDR brachytherapy with flexible implants for interstitial boost after breast-conserving surgery and external beam radiation therapy 显示文摘 | Fritz P Bems C Anton HW | 1997 | Radiother Oncol1997，45，1： | 1 |
| 3 | The History of South American tropical precipitation for the past 25000 years显示文摘 | Baker P A Seltzer G O Fritz S C | 2001 | Science2001，291，： | 1 |
| 4 | Articular cartilage defects inthe knee - basics, therapies and results 显示文摘 | Fritz J Janssen P Gaissmaier C | 2008 | Injury2008，1，： | 1 |
| 5 | Articular cartilage defects in the knee-basics,therapies and results 显示文摘 | Fritz J Janssen P Gaissmaier C | 2008 | Injury2008，39，： | 1 |
| 6 | Expression and function of beta - glucuronidase in pancreatic cancer: potential role in drug targeting 显示文摘 | Sperker B Werner U Miirdter TE Tekkaya C Fritz P Wacke R Adam U Gerken M Drewelow B Kroemer HK | 2000 | Naunyn Schmiedebergs Arch Pharma- col2000，362，2： | 1 |
| 7 | Mechanism of resistance to fungicides in field strains of Botrytis cinerea显示文摘 | Leroux P Fritz R Debieu Albertini C | 2002 | Pest Managemnet Science2002，58，： | 1 |
| 8 | The weekend matters: Relationships between stress recovery and affective experiences显示文摘 | FRITZ C SONNETAGE S SPECTOR P E | 2010 | Journal of Organizational Behavior2010，31，8： | 1 |
| 9 | The history of South Ameri- can tropical precipitation for the past 25, 000 years 显示文摘 | Baker P A Seltzer G O Fritz S C | 2001 | Science2001，291，5504： | 1 |
| 10 | The presence of an iron-sulfur cluster in adenosine 5’-phosphosulfate reductase separates organisms utilizing adenosine 5’-phosphosulfate and phosphoadenosine 5’-phosphosulfate for sulfate assimilation 显示文摘 | Kopriva S Büchert T Fritz G Suter M Benda R Schünemann V Koprivova A Schürmann P Trautwein AX Kroneck PM Brunold C | 2002 | J Biol Chem2002，277，21： | 1 |
| 11 | Late-Quaternary cli- matic trends and history of Lake Erie from stable isotope stud- ies显示文摘 | Fritz P Anderson T W Lewis C F M | 1975 | Science1975，190，： | 1 |
| 12 | The History of South American tropical precipitation for the past 25 000 years 显示文摘 | Baker P A Seltzer G O Fritz S C | 2001 | Science2001，291，： | 1 |
| 13 | Properties and morphology of polyester blends and of fibers made therefrom显示文摘 | Oppermann W Hirt P Fritz C | 1999 | Chemical Fibers International1999，49，1： | 1 |
| 14 | Tamoxifen attenuates the effects of exgenous glucocorticoids on bone formation and growth in piglets显示文摘 | Fritz P C Ward W E Atkinson S A | 1998 | Endocrinology1998，139，： | 1 |
| 15 | Articular cartilage defects in the knee - basics, therapies and results 显示文摘 | Fritz J Janssen P Gaissmaicr C | 2008 | Injury Apr2008，，： | 1 |
| 16 | The weekend matters: Relationships between stress recovery and affective experiences 显示文摘 | Fritz C Sonnentag S Spector P E | 2010 | Journal of Organizational Behavior2010，31，8： | 1 |
| 17 | Translating Biomolecular Recognition into Nanomechanics显示文摘 | Baller M K Lang H P Rothuizen H Vettiger P Meyer E Guntherodt H J Gerber C Gimzewski J K | 2000 | Science2000，288，： | 1 |
| 18 | Impact of the C-N status on the amino acid profile in tobacco source leaves 显示文摘 | Fritz C Mueller C Matt P | 2006 | Plant Cell Environ2006，29，11： | 1 |
| 19 | Inhibition of dioxin effects on bone formation in vitro by a newly described aryl hydrocarbon receptor antagonist, resveratrol 显示文摘 | SINGH S U CASPER R F FRITZ P C | 2000 | J Endocrinol2000，167，3： | 1 |
| 20 | The history of South American tropical precipitation for the past 25,000 years显示文摘 | Baker P A Seltzer G O Fritz S C | 2001 | Science2001，291，： | 1 |
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