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| 1 | Effect of rapamycin on hepatic osteodystrophy in rats with portasystemic shunting显示文摘瞄准:如果与推延的 portasystemic 有关的 T 房间激活通过 RANKL 依赖的小径引起调停骨破折的骨头损失,学习。如果用 rapamycin 的 T 房间抑制将在老鼠免于骨头损失,我们也调查了。方法:推延的 Portasystemic 在男 Sprague-Dawley 老鼠和 rapamycin 被执行 0.1 mg/kg 被管饲法为 15 wk 管理。老鼠收到了 powderized 食物并且补加喂在骨头作文上阻止营养不良的效果。重量获得和生长在推延的动物在外科以后被恢复。在结束,骨头周转和量的骨头组织学的生物化学的参数被估计。T 房间激活,煽动性的 cytokine 生产,和 RANKL 依赖的小径的标记被测量。另外, IGF-1 和性腺机能减退的角色被调查。结果:推延的 Portasystemic 引起了是 RANKL 独立人士的低周转骨质疏松症。包括 IL-1, IL-6 和 TNFalpha,骨头再吞 cytokine 层次没在浆液和 TNFalpha 被增加, RANKL 表示不起来在 PBMC 调整了。推延的 Portasystemic 增加了传播 CD8+T 房间人口。Rapamycin 减少了传播 CD8+T 房间人口,增加了 CD8+CD25+T 规章的房间人口并且改进了骨头周转的所有参数。结论:推延的 portasystemic 引起的骨质疏松症可以被 rapamycin 部分在肝的骨营养不良的老鼠模型改善。 | Schalk W van der Merwe Maria M Conradie Robert Bond Brenda J Olivier Elongo Fritz Martin Nieuwoudt Rhena Delport Tomas Slavik Gert Engelbrecht Del Kahn Enid G Shephard Maritha J Kotze Nico P de Villiers Stephen Hough | 2006 | World Journal of Gastroenterology2006，12，28： | 2 |
| 2 | Acid catalysis by dealuminated zeolite-Y I Methanol dehydration and cumene dealkylation显示文摘 | DECANIO S J SOHN J R FRITZ P O | 1986 | Journal of Catalysis1986，101，1： | 1 |
| 3 | Fractionation of sulfur and oxygen isotopes in sulfate by soil sorption 显示文摘 | van Stempvoort D R Reardon E J Fritz P | 1990 | Geochim Cosmochim Acta1990，54，10： | 1 |
| 4 | Translating biomolecular recognition into nanomechanics显示文摘 | Fritz J Bailer M K Lang H P | 2000 | Science2000，288，： | 1 |
| 5 | The effect of sodium poisoning on dealuminated Y-type zeolites显示文摘 | FRITZ P O LUNSFORD J H | 1989 | Journal of Catalysis1989，118，1： | 1 |
| 6 | Seasonal chemical and isotopic variations of soil CO2 at Trout Creek,Outario显示文摘 | REARDON E J ALLISON G B FRITZ P | 1979 | Journal of Hydrology1979，43，1： | 1 |
| 7 | The carbon isotope geochemistry of a small groundwater system in northeastern Ontario显示文摘 | FRITZ P REARDON E J BARKER J | 1987 | Water Resources Research1987，14，6： | 1 |
| 8 | Translating biomolecular recognition into nanomechanics显示文摘 | Fritz J Baller M K Lang H P | 2000 | Science2000，288，14： | 1 |
| 9 | Isolation of DNA from plants high in polyphenolics显示文摘 | Couchu J A Fritz P J | 1990 | Plant Mol Biol Rep1990，8，： | 1 |
| 10 | Photon counting multienergy x - ray imaging: effect of the characteristic x rays on detector performance 显示文摘 | Shikhaliev P M Fritz S G Chapman J W | 2009 | Medical Physics2009，36，11： | 1 |
| 11 | Translating biomolecular recognition into nanomechanics 显示文摘 | FRITZ J BALLER M K LANG H P | 2000 | Science2000，288，5464： | 1 |
| 12 | Colour development of immunogold-labelled antibodies for light microscopy显示文摘 | Fritz P Hoenes J Schenk J | 1986 | Histochemistry1986，85，3： | 1 |
| 13 | Geochemistry of Bra- chiopods, Oxygen and Carbon Isotopic Records of Paleozoic Oceans 显示文摘 | Veizer J Fritz P Jones B | 1986 | Geochim Cosmochim Acta1986，50，8： | 1 |
| 14 | Distribution of the product confidence limits for the indirect effect: Program prodclin 显示文摘 | MACKINNON D P FRITZ M S WILLIAMS J | 2007 | Behavior Research Methods2007，39，3： | 1 |
| 15 | Isolation of DNA from plants high in polyphenolics 显示文摘 | COUCH J A FRITZ P J | 1990 | Plant Mol Biol Rep1990，8，1： | 1 |
| 16 | Mediation analysis显示文摘 | MACKINNON D P FAIRCHILD A J FRITZ M S | 2007 | Annual Review of Psychology2007，58，： | 1 |
| 17 | Off-pump versus on-pump coronary bypass in high-risk subgroups显示文摘 | Taro Yokoyama Fritz J Baumgartner Ali Gheissari Eli R Capouya George P Panagiotides Richard J Declusin | 2000 | The Annals of Thoracic Surgery2000，，5： | 1 |
| 18 | Articular cartilage defects inthe knee - basics, therapies and results 显示文摘 | Fritz J Janssen P Gaissmaier C | 2008 | Injury2008，1，： | 1 |
| 19 | Translating biomolecular recognition into nanomechanics 显示文摘 | FRITZ J BALLER M K LANG H P | 2000 | Science2000，288，5464： | 1 |
| 20 | Articular cartilage defects in the knee-basics,therapies and results 显示文摘 | Fritz J Janssen P Gaissmaier C | 2008 | Injury2008，39，： | 1 |
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